Produkte von Chimerigen

Chimerigen

Chimerigen produziert einzigartige Immunglobulin-basierte chimäre Fusionsproteine und verwandte Forschungs-Produkte mit Hilfe modernster zell-und molekularbiologischen Techniken. Diese Reagenzien werden erfolgreich in Grundlagenforschung und angewandter Forschung eingesetzt.

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IL-22 (mouse):Fc (mouse) (rec.) (non-lytic)
IL-22 (mouse):Fc (mouse) (rec.) (non-lytic)

Artikelnummer: CHI-MF-12022-C050

Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in...
Anwendung: Bioassays
Wirt: Hamster cells
Reaktivität: Mouse
Reinheit: >98%
Format: Lyophilized
ab 281,00 €
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Galectin-9 (human):Fc (human) (rec.)
Galectin-9 (human):Fc (human) (rec.)

Artikelnummer: CHI-HF-210GAL9-C050

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of...
Anwendung: Bioassays
Wirt: Human cells
Reaktivität: Human
Reinheit: >95%
Format: Lyophilized
341,00 €
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IL-35 (mouse):Fc (human) (rec.)
IL-35 (mouse):Fc (human) (rec.)

Artikelnummer: CHI-MF-11135-C025

The mouse IL-35 complex composed of the Ebi3 subunit (aa 23-228) and the IL-12a (p35) subunit (aa 23-215) is fused through a polypeptide linker to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Interleukin-35 (IL-35) is a novel IL-12 family cytokine produced by regulatory T cells (Treg) but not by resting or activated effector T cells (Teff)....
Anwendung: Bioassays
Wirt: Hamster cells
Reaktivität: Mouse
Reinheit: >98%
Format: Lyophilized
ab 286,00 €
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IL-35 (human):Fc (human) (rec.)
IL-35 (human):Fc (human) (rec.)

Artikelnummer: CHI-HF-21035-C025

The human IL-35 complex composed of the Ebi3 subunit (aa 21-229) and the IL-12a (p35) subunit (aa 57-253) is fused through a polypeptide linker to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Interleukin-35 (IL-35) is a novel IL-12 family cytokine produced by regulatory T cells (Treg) but not by resting or activated effector T cells (Teff)....
Anwendung: Bioassays
Wirt: Hamster cells
Reaktivität: Human
Reinheit: >98%
Format: Lyophilized
253,00 €
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IL-2 (human) Superkine (Fc) MultiPack
IL-2 (human) Superkine (Fc) MultiPack

Artikelnummer: CHI-ZHF-21002S-C010

3 x 10 µg. Triggers far greater antitumor responses than native IL-2 in vivo but with lower toxicity. The extracellular domain of human IL-2 (aa 21-153) (mutant H9 containing the mutations L80F / R81D / L85V / I 86V / I92F) is fused at the C-terminus to the Fc portion of human IgG2. Binds to human and mouse IL-2R. IL-2 Protein function: Produced by T-cells in response to...
Anwendung: Bioassays
Wirt: Human cells
Reaktivität: Human
Reinheit: >95%
Format: Lyophilized
ab 330,00 €
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CD274 [B7-H1/PD-L1] (human):Fc (human) (rec.)
CD274 [B7-H1/PD-L1] (human):Fc (human) (rec.)

Artikelnummer: CHI-HF-210PDL1-C100

The extracellular domain of human CD274 [B7-H1] (aa 19-238) is fused to the N-terminus of the Fc region of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified...
Anwendung: Bioassays
Wirt: Hamster cells
Reaktivität: Human
Reinheit: >98%
Format: Lyophilized
385,00 €
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IL-23 (mouse):Fc (human) (rec.)
IL-23 (mouse):Fc (human) (rec.)

Artikelnummer: CHI-MF-11123-C050

The mouse IL-23 complex composed of the p40 subunit (aa 23-335) and the p19 subunit (aa 20-196) is fused through a polypeptide linker to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. 0 Interleukin-23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is...
Anwendung: Bioassays
Wirt: Hamster cells
Reaktivität: Mouse
Reinheit: >98%
Format: Lyophilized
374,00 €
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IL-22 (human):Fc (human) (rec.) (non-lytic)
IL-22 (human):Fc (human) (rec.) (non-lytic)

Artikelnummer: CHI-HF-22022-C050

The extracellular domain of human IL-22 (aa 34-179) is fused at the C-terminus to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the IL-22 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible...
Anwendung: Bioassays
Wirt: Hamster cells
Reaktivität: Human
Reinheit: >98%
Format: Lyophilized
ab 281,00 €
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IL-7 (human) (rec.) (His)
IL-7 (human) (rec.) (His)

Artikelnummer: CHI-HF-20107-C050

Interleukin-7 (IL-7), is a hematopoietic growth factor and a member of the IL-7/IL-9 family. IL-7 stimulates the proliferation of lymphoid progenitors and is secreted by stromal cells in the bone marrow and thymus. IL-7 is also important for proliferation during certain stages of B cell maturation. IL-7 and the hepatocyte growth factor (HGF) form a heterodimer that functions...
Anwendung: Bioassays
Wirt: Human cells
Reaktivität: Human
MW: ~27 kD
Reinheit: >95%
Format: Lyophilized
ab 220,00 €
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IL-18 (human) (rec.) (His)
IL-18 (human) (rec.) (His)

Artikelnummer: CHI-HR-20018-C050

Interleukin-18 (IL-18) is a costimulatory factor for production of interferon-gamma (IFN-gamma) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in...
Anwendung: Bioassays
Wirt: E.coli
Reaktivität: Human
Reinheit: >97%
Format: Lyophilized
ab 149,00 €
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CD152 [CTLA-4] (human):Fc (human) (rec.)
CD152 [CTLA-4] (human):Fc (human) (rec.)

Artikelnummer: CHI-HF-210A4-M001

The extracellular domain of human CD152 [CTLA-4] is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Binds both CD80 (B7-1) and CD86 (B7-2) with high affinity and inhibits CD28 signaling competitively. Kills the target cell completely. CD152 [CTLA-4] and CD28, together with their ligands B7-1 and B7-2, constitute one...
Anwendung: Bioassays
Wirt: Mouse cells
Reaktivität: Human
Reinheit: >98%
Format: Lyophilized
ab 99,00 €
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IL-17A (human):Fc (human) (rec.) (non-lytic)
IL-17A (human):Fc (human) (rec.) (non-lytic)

Artikelnummer: CHI-HF-22017A-C050

Interleukin-17A (IL-17A) exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblsts, the enhancement of surface expression of ICAM-1 in fibroblast, activation of NF-kappaB and costimulation of T cell proliferation. Induces stromal cells to produce proinflammatory and hematopoietic cytokines.
Anwendung: Bioassays
Wirt: Human cells
Reaktivität: Human
MW: ~42 kD
Reinheit: >98%
Format: Lyophilized
341,00 €
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