Rekombinante Zytokine

Authentic recombinant human protein, human cell expressed, which in general ensures proper folding, phosphorylation, disulfide bridge formation, proteolytic processing, and glycosylation. Endotoxin <0.1 EU/µg.

Authentic recombinant human protein, human cell expressed, which in general ensures proper folding, phosphorylation, disulfide bridge formation, proteolytic processing, and glycosylation. Endotoxin <0.5 EU/µg.

(3 x 10 µg). Human FasL (aa 139-281) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG(R)-tag. Lyophilized. Contains PBS. MultimericFasL (human) is a high activity construct in which two trimeric FasL are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of FasL...

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. (www.uniprot.org) Produced in E.coli. Single, non-glycosylated, polypeptide chain containing 67 amino acids. The ED50 is less then 1.0 ng/ml, corresponding to a specific...

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell...

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. (www.uniprot.org) Produced in E.coli. Single, non-glycosylated, polypeptide chain, 166 amino acids. The specific activity as determined in a viral resistance assay was found to be 1 x 108 IU/ mg.

Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3) / ERK2 (MAPK1),...

Active human TGFb1 (GenBankAccession #NM_000660), a.a. 279-390(end), disulfide-linked homodimer. MW= approx. 25 kDa. Biological Activity: measured by TGFbeta1s ability to inhibit mIL-4-dependentproliferation of HT-2 mouse helper T cells.The ED50 is <0.05ng/ml.

Protein function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells,...

Protein function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. [The UniProt Consortium]

(3 x 10 µg). Human CD40L (amino acids 116-261) is fused at the N-terminus to mouse ACRP30headless (amino acids 18-111) and a FLAG(R)-tag. Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: <1ng/ml). Lyophilized. Contains PBS MultimericCD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via the...

Human BAFF (amino acids 134-285) is fused at the N-terminus to a His-tag. Lyophilized. Binds to human and mouse BAFF-R, TACI and BCMA. Relative binding affinity (EC50) for BAFF-R (human): 3ng/ml. Increases B cell survival /Proliferation. Increases CD21 / CD23 expression on B cells in vivo. Activates BAFF-R, TACI and BCMA receptors. Works at concentrations <20ng/ml.