Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-MAPT (etalanetug biosimilar) mAb
Artikelnummer: DIM-BME100498.100
Research use only. Protein function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein...
| Schlagworte: | E-2814,E2814,E 2814, Anti-MAPTL, Anti-PHF-tau, Anti-Paired helical filament-tau, Anti-Neurofibrillary tangle protein,... |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-BTLA (icatolimab biosimilar)mAb
Artikelnummer: DIM-BME100054.100
Protein function: Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis...
| Schlagworte: | Anti-BTLA, Anti-CD272, Anti-BTLA (icatolimab biosimilar)mAb |
| Wirt: | Chimeric |
| Spezies-Reaktivität: | human |
ab 120,00 €
Human PSMA Protein, hFc Tag
Artikelnummer: DIM-PME100390.100
Recombinant human PSMA protein with N-terminal human Fc tag. hFc(Glu99-Ala330) PSMA(Lys44-Ala750), Protein function: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of...
| Schlagworte: | FGCP, FOLH, GCP2, GCPII, mGCP, NAALAD1, NAALAdase, PSM, PSMA |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 105.7 kD |
ab 114,00 €
Human MMP14 Protein, hFc Tag
Artikelnummer: DIM-PME100675.100
Recombinant Human MMP14 with C-terminal human Fc tag. MMP14(Tyr112-Ala541) hFc(Glu99-Ala330), Protein function: Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal...
| Schlagworte: | MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 75.3 kD |
ab 176,00 €
Anti-OSMR(vixarelimab biosimilar) mAb
Artikelnummer: DIM-BME100148.50
Protein function: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. [The UniProt Consortium]
| Schlagworte: | Anti-IL-31 receptor subunit beta, Anti-IL-31R subunit beta, Anti-IL-31R-beta, Anti-IL-31RB, Anti-OSMR(vixarelimab... |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Human CD28 Protein, mFc-His Tag
Artikelnummer: DIM-PME100014.50
Recombinant human CD28 protein with C-terminal mouse Fc and 6×His tag. CD28(Asn19-Pro152) mFc(Pro99-Lys330) 6×His, Protein function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in...
| Schlagworte: | CD28, Tp44 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 68-72 kD |
ab 140,00 €
Human HER3 Protein, His Tag
Artikelnummer: DIM-PME100088.50
Recombinant Human HER3 protein with C-terminal 6×His tag. HER3(Ser20-Thr643) 6×His tag, Protein function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues...
| Schlagworte: | HER3, ERBB3 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 69.39 kD |
ab 124,00 €
Anti-FZD10 antibody(DMC487), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100487.100
Protein function: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second...
| Schlagworte: | Anti-CD350, Anti-FZ-10, Anti-Fz10, Anti-FzE7, Anti-hFz10, Anti-FZD10 antibody(DMC487), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-TSHR (M22) mAb
Artikelnummer: DIM-BME100079.50
Protein function: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate...
| Schlagworte: | Anti-CHNG1, Anti-hTSHR-I, Anti-LGR3, Anti-TSHR (M22) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Human PSMA Protein, His Tag
Artikelnummer: DIM-PME100545.100
Recombinant human PSMA protein with N-terminal 6×His tag. 6×His tag PSMA(Lys44-Ala750), Protein function: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the...
| Schlagworte: | FGCP, FOLH, GCP2, GCPII, mGCP, NAALAD1, NAALAdase, PSM, PSMA |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 80.3 kD |
ab 200,00 €
Human FAP (30-760) Protein, His Tag
Artikelnummer: DIM-PME100626.50
Recombinant human FAP(30-760) protein with N-terminal 6×His tag. 6×His tag FAP(Arg30-Asp760), Protein function: Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation...
| Schlagworte: | FAP, FAPalpha, SIMP, Seprase, APCE |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 85.4 kD |
ab 105,00 €
Human FCRL5(745-850)Protein, hFc Tag
Artikelnummer: DIM-PME101494.10
Recombinant human FCRL5(745-850)Protein with N-terminal human Fc tag. hFc(Glu99-Ala330)FCRL5(Val745-Thr850), Protein function: May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone...
| Schlagworte: | CD307, FCRH5, IRTA2, BXMAS1, CD307e, PRO820 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 37.2 kD |
ab 102,00 €