Produkte von LKT Laboratories

LKT

LKT Laboratories ist ein F&E Unternehmen, das sich auf die Entwicklung von pharmakologischen Substanzen zur Bekämpfung von Krebs- und anderen Erkrankungen konzentriert. Bei der Herstellung dieser Wirkstoffe entstehen Substanzen, die auch für die Life-Science-Forschung als Bioreagenzien extrem nützlich sind und von LKT im analytischen Maßstab angeboten werden.

Mehr unter: www.lktlabs.com

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Nitisinone
Nitisinone

Artikelnummer: LKT-N3476.50

Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
Schlagworte: NTBC, orfadin
Anwendung: 4-hydroxyphenylpyruvate dioxygenase inhibitor
CAS 104206-65-7
MW: 329.23 D
ab 63,00 €
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Carmustine
Carmustine

Artikelnummer: LKT-C0173.100

Carmustine is an antitumor agent.
Schlagworte: BCNU, bis-chloroethylnitrosourea
Anwendung: Anticancer agent
CAS 154-93-8
MW: 214,05 D
ab 75,00 €
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Isoflurane
Isoflurane

Artikelnummer: LKT-I7258.250

Isoflurane is an anesthetic most commonly used in veterinary medicine. Isoflurane exhibits cardiomodulatory, neuromodulatory, and pro-inflammatory activities. In diabetic rats, isofluorane decreases cardiac force and intracellular Ca2+ amplitude. Isoflurane also increases IL-6 and NF-kappaB levels in glioma cells...
Anwendung: Anesthetic [inhalation]
CAS 26675-46-7
MW: 184.49 D
ab 58,00 €
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ASTX660
ASTX660

Artikelnummer: LKT-A744789.1

ASTX660 is an inhibitor of apoptosis proteins found to target BIR3 domain of cIAP1/2 and XIAP through a TNFalpha dependent mechanism in melanoma, breast cancer, and lymphoma cell studies. In a breast cancer xenograft model ASTX660 inhibited tumor growth while displaying no significant adverse effects. Treatment of...
Schlagworte: ASTX660, ASTX-660, ASTX 660, Ethanone,...
Anwendung: CIAP / XIAP dual antagonist
CAS 1799328-86-1
MW: 539.7 D
ab 453,00 €
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Baloxavir
Baloxavir

Artikelnummer: LKT-B011458.1

Baloxavir, and its prodrug baloxavir marboxil, is a cap-dependent endonuclease inhibitor, leading to inhibition of RNA transcription and replication. Baloxavir shows potent activity against two influenza A strains with noted synergistic effects when used in combination with oseltamivir. Baloxavir has also been...
Schlagworte: Baloxavir acid, 4G86Y4JT3F,...
Anwendung: Antiviral, Cap-dependent endonuclease inhibitor
CAS 1985605-59-1
MW: 483.5 D
ab 101,00 €
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Baloxavir Marboxil
Baloxavir Marboxil

Artikelnummer: LKT-B011460.100

Baloxavir, and its prodrug baloxavir marboxil, is a cap-dependent endonuclease inhibitor, leading to inhibition of RNA transcription and replication. Baloxavir shows potent activity against two influenza A strains with noted synergistic effects when used in combination with oseltamivir. Baloxavir has also been...
Schlagworte: Xofluza, S-033188,...
Anwendung: Antiviral, Cap-dependent endonuclease inhibitor, Prodrug
CAS 1985606-14-1
MW: 571.6 D
ab 123,00 €
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Bedaquiline Fumarate
Bedaquiline Fumarate

Artikelnummer: LKT-B165121.100

Bedaquiline is a diarylquinoline found to be useful in treating multidrug-resistant tuberculosis. In mouse models of TB, bedaquiline has significantly shortened the treatment regimen. A long-acting injectable formulation has been shown to have prolonged bactericidal activity. Bedaquiline inhibits ATP-synthase, and...
Schlagworte: (1R,2S)-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-2-butanol (2E)-2-butenedioate (1:1)
Anwendung: Antibacterial (tuberculostatic), ATP synthase inhibitor
CAS 845533-86-0
MW: 671.59 D
ab 194,00 €
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Camalexin
Camalexin

Artikelnummer: LKT-C016481.100

Camalexin is a phytoalexin found in various cruciferous plants after exposure to environmental stresses. Studies on acute myeloid leukemia cells show that camalexin selectively decreases cell viability. Several studies have already shown that exposure to camalexin causes cell shrinkage and phospholipid scrambling in...
Schlagworte: 3-(1,3-thiazol-2-yl)-1H-indole, 3-(thiazol-2-yl)indole, 2-(1H-indol-3-yl)-1,3-thiazole
Anwendung: Bioactive phytoalexin
CAS 135531-86-1
MW: 200.26 D
ab 84,00 €
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LY-3214996
LY-3214996

Artikelnummer: LKT-L960012.100

LY-3214996 is a selective inhibitor of ERK1/2. ERK1/2 inhibitors offer a targeted approach to cancers in which the RAS/MAPK signaling pathway is dysregulated. These compounds can be successful when Braf and MEK inhibitor efficacy is lost due to developed drug resistance. LY-3214996 has demonstrated potent antitumor...
Schlagworte: LY 3214996, LY3214996, LY-3214996
Anwendung: Selective ERK1/2 inhibitor
CAS 1951483-29-6
MW: 453.57 D
ab 136,00 €
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4-(Methylsulfinyl) butylamine
4-(Methylsulfinyl) butylamine

Artikelnummer: LKT-M185777.10

4-(Methylsulfinyl) butylamine is the synthetic precursor of sulforaphane.
Schlagworte: Schembl371434, CTK7E8172, 4-methanesulfinylbutan-1-amine, (+/-)-1-amino-4-(methylsulfinyl)butane,...
Anwendung: Synthetic sulforaphane precursor
CAS 187587-70-8
MW: 135.23 D
ab 58,00 €
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L-(-)-Norepinephrine-(+)-bitartrate
L-(-)-Norepinephrine-(+)-bitartrate

Artikelnummer: LKT-N582686.1

Norepinephrine is a hormone and neurotransmitter that modulates sympathetic nervous system activity and plays a role in modulating reward, reinforcement, feeding, and other behaviors. Norepinephrine exhibits vasoconstrictive, pro-angiogenic, and thermoregulatory activities. Norepinephrine is clinically used to treat...
Schlagworte: L-(-)-Norepinephrine-(+)-bitartrate, 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol, 2,3-dihydroxybutanedioic acid,...
Anwendung: Hormone, Neurotransmitter
CAS 69815-49-2
MW: 319.26 D
ab 54,00 €
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(±)-Goitrin
(±)-Goitrin

Artikelnummer: LKT-G571344.100

(±)-Goitrin is a bioactive component found in cruciferous vegetables and other plants such as Isatis indigotica. In a study using a rat model, the presence of (±)-goitrin in the diet resulted in a hypothyroid state. The biological activities of the individual enantiomers are curiously different from one another,...
Schlagworte: 5-Vinyloxazolidinone-2-thione, DL-Goitrin, R,S-Goitrin, 5-ethenyl-2-oxazolidinethione
Anwendung: Goitrogen, Antiviral
CAS 13190-34-6
MW: 129.18 D
ab 253,00 €
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