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Cal-590(TM)-Dextran Conjugate *MW 10,000* Artikelnummer: ABD-20509
Calcium measurement is critical for numerous biological investigations. Fluorescent probes that show spectral responses upon binding calcium have enabled researchers to investigate changes in intracellular free calcium concentrations by using fluorescence microscopy, flow cytometry, fluorescence spectroscopy and...
| Anwendung: | IF, FC |
319,00 €
Vulpinic Acid Artikelnummer: Cay21685-100
Vulpinic acid is a lichen metabolite that has been found in L. vulpina and has diverse biological activities. It is active against C. perfringens, B. vulgatus, B. fragilis, B. loescheii, P. acnes, E. faecium, and methicillin-susceptible and -resistant S. aureus (MICs = 4-16 µg/ml). Vulpinic acid (25-800 µM) prevents...
| Schlagworte: | NSC 5897, alphaE-(3-hydroxy-5-oxo-4-phenyl-2(5H)-furanylidene)-benzeneacetic acid, methyl ester |
| Anwendung: | Bioactive lichen metabolite |
| CAS | 521-52-8 |
| MW: | 322.3 D |
ab 32,00 €
Thymohydroquinone Artikelnummer: Cay27558-10
Thymohydroquinone is a quinone that has been found in N. sativa seeds and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) free radicals in a cell-free assay (IC50 = 2.4 µg/ml) and has a Trolox equivalent value of 2.6 in an oxygen radical absorbance capacity (ORAC)...
| Schlagworte: | NSC 34803, 2-methyl-5-(1-methylethyl)-1,4-benzenediol |
| Anwendung: | Bioactive quinone |
| CAS | 2217-60-9 |
| MW: | 166.2 D |
ab 32,00 €
NEU
AR-C 155858 Artikelnummer: Cay14884-1
AR-C 155858 is an inhibitor of monocarboxylate transporter 1 (MCT1) and MCT2 (Kis = 2.3 and Xenopus oocytes expressing the human receptors). It is selective for MCT1 and MCT2 over MCT4 (Ki = >10 µM). AR-C 155858 inhibits L-lactate uptake in and proliferation of murine 4T1 breast cancer cells (IC50s = 25 and 20.2 nM,...
| Schlagworte: | 6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-thieno[... |
| Anwendung: | Monocarboxylate transporter 1/2 inhibitor |
| CAS | 496791-37-8 |
| MW: | 461.5 D |
374,00 €
NEU
KT185 Artikelnummer: Cay19113-50
KT185 is an orally bioavailable inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 0.21 nM in a competitive activity-based protein profiling assay using Neuro2A membranes. It inhibits ABHD6 in a 2-arachidonoyl glycerol (2-AG, Cay-62160) hydrolysis assay (IC50 = 13.6 nM for...
| Schlagworte: | [4'-[1-[(2-phenyl-1-piperidinyl)carbonyl]-1H-1,2,3-triazol-4-yl][1,1'-biphenyl]-3-yl]-1-piperidinyl-methanone |
| Anwendung: | ABHD6 inhibitor |
| CAS | 1472640-86-0 |
| MW: | 519.6 D |
ab 94,00 €
NEU
Diclofenac amide Artikelnummer: Cay21969-500
Diclofenac amide is a prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Cay-70680, Cay-22983). It decreases paw thickness in a rat model of carrageenan-induced paw edema when administered at a dose of 100 µmol/kg and decreases acetic acid-induced writhing in mice at 100 µmol/kg. Diclofenac...
| Schlagworte: | 1-(2,6-Dichlorophenyl)oxindole, Diclofenac Lactam, NSC 621845, 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one |
| Anwendung: | NSAID prodrug |
| CAS | 15362-40-0 |
| MW: | 278.1 D |
ab 35,00 €
NEU
6-OHDA (hydrobromide) Artikelnummer: Cay25330-1
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra,...
| Schlagworte: | 2,4,5-Trihydroxyphenethylamine, 6-hydroxy Dopamine, Oxidopamine, 5-(2-aminoethyl)-1,2,4-benzenetriol, monohydrobromide |
| Anwendung: | Catecholaminergic neurotoxin |
| CAS | 636-00-0 |
| MW: | 250.1 D |
435,00 €
NEU
(±)-trans-GK563 Artikelnummer: Cay25732-5
trans-(±)-GK563 is a potent beta-lactone inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (GVIA iPLA2, IC50 = 1 nM). It is selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 µM). trans-(±)-GK563 (1 and 10 µM) inhibits apoptosis induced by IL-1beta and IFN-gamma in INS-1 beta-cells.
| Schlagworte: | GK563, (3R,4R)-rel-3-(4-phenylbutyl)-4-propyl-2-oxetanone |
| Anwendung: | IPLA2beta inhibitor |
| CAS | 2351820-19-2 |
| MW: | 246.3 D |
ab 94,00 €
NEU
TP-238 (hydrochloride) Artikelnummer: Cay27254-5
TP-238 is a chemical probe for the bromodomains of cat eye syndrome chromosome region, candidate 2 (CECR2) and bromodomain PHD finger transcription factor (BPTF). It has on-target biochemical activity with CECR2 when used at concentrations ranging from 10 to 30 nM and with BPTF at concentrations ranging from 100 to...
| Schlagworte: | N-(3-(1H-pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine, hydrochloride |
| Anwendung: | Chemical CECR2 & BPTF bromodomain probe |
| MW: | 49.5 D |
ab 95,00 €
NEU
Melanotan II (acetate) Artikelnummer: Cay27316-5
Melanotan II is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (Kis = 0.67, 34, 6.6, and 46 nM, respectively, in COS cells expressing human recombinant receptors). It improves recovery of sciatic nerve function after mechanical injury in rats, and increases cisplatin-induced decreases in sensory...
| Schlagworte: | MT II, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide, (2->7)-lactam,... |
| Anwendung: | Melanocortin receptor (MC1R, MC3R, MC4R, MC5R) agonist |
| MW: | 1024.2 D |
ab 157,00 €
NEU
BMS 779788 Artikelnummer: Cay27339-5
BMS 779788 is a partial agonist of liver X receptor alpha (LXRalpha) and LXRbeta (Kis = 68 and 14 nM, respectively, in a radioligand binding assay). It activates LXRalpha and LXRbeta with EC50 values of 230 and 250 nM, respectively, in a transactivation assay. BMS 779788 increases expression of ATP-binding cassette...
| Schlagworte: | 2-[1-(2-chlorophenyl)-1-methylethyl]-alpha,alpha-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-1H-imidazole-4-methanol |
| Anwendung: | LXR alpha & beta partial agonist |
| CAS | 918348-67-1 |
| MW: | 509.1 D |
ab 57,00 €
NEU
Des(benzylpyridyl) Atazanavir Artikelnummer: Cay27372-5
Des(benzylpyridyl) atazanavir is a major metabolite of the HIV-1 protease inhibitor atazanavir (Cay-11733). It is formed from atazanavir by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2D6.
| Schlagworte: | Atazanavir metabolite M1,... |
| Anwendung: | Major metabolite |
| CAS | 1192224-24-0 |
| MW: | 537.7 D |
ab 99,00 €
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