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Thiazolyl blue (MTT) 3-(4,5-Dimethyl-2-thiazolyl)-2...
Artikelnummer: 15655.1
MTT, a yellow tetrazole, is reduced to purple formazan in living cells. A solubilization solution (usually either dimethyl sulfoxide, an acidified ethanol solution, or a solution of the detergent sodium dodecyl sulfate in diluted hydrochloric acid) is added to dissolve the insoluble purple formazan product into a...
| Anwendung: | Cell viability assay |
| CAS | 298-93-1 |
| MW: | 414.33 |
ab 82,00 €
Dithiothreitol (DTT)
Artikelnummer: 04010.10
DTT is an unusually strong reducing agent, because once oxidized, it forms a stable six-membered ring with an internal disulfide bond. The reduction usually does not stop at the mixed-disulfide species because the second thiol of DTT has a high propensity to close the ring, forming oxidized DTT and leaving behind a...
| Anwendung: | Reducing agent |
| CAS | 3483-12-3 |
| MW: | 154.25 |
ab 44,00 €
Glycine, ultra pure
Artikelnummer: 04943.1
Glycine (abbreviated as Gly or G) is the smallest of the 20 amino acids commonly found in proteins, having a hydrogen substituent as its side-chain. Its codons are GGU, GGC, GGA, GGG of the genetic code. Glycine is often used as a counterion in SDS-PAGE and in buffers for western blotting.
| Anwendung: | Buffer component, Protein stabilization |
| CAS | 56-40-6 |
| MW: | 75.07 |
ab 87,00 €
NAD+, free acid
Artikelnummer: 16110.1
Nicotinamide adenine dinucleotide, abbreviated NAD+, is a coenzyme found in all living cells. The compound is a dinucleotide, since it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base and the other nicotinamide.In metabolism, NAD+ is involved in redox...
| Schlagworte: | NAD+ beta-Nicotinamide-adenine-dinucleotide, oxidized form |
| CAS | 53-84-9 |
| MW: | 663.44 D |
ab 50,00 €
Dimethylsulfoxide (DMSO)
Artikelnummer: 54686.100
DMSO is a polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. DMSO is less toxic than other members of this class, such as dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, and HMPA. DMSO is also used in PCR to...
| Anwendung: | Protein stabilization |
| CAS | 67-68-5 |
| MW: | 78.13 |
ab 44,00 €
Y-27632 (hydrochloride)
Artikelnummer: Cay10005583-10
The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50...
| Schlagworte: | 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide, dihydrochloride |
| Anwendung: | ROCK inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.3 D |
ab 87,00 €
Cytochalasin D
Artikelnummer: Cay11330-1
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit...
| Schlagworte: | NSC 209835,... |
| Anwendung: | Cell-permeable actin polymerization inhibitor |
| CAS | 22144-77-0 |
| MW: | 507.6 D |
ab 103,00 €
Ionomycin (calcium salt)
Artikelnummer: Cay11932-1
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...
| Schlagworte: | 11,19R,21S-trihydroxy-4R,6S,8S,12R,14R,18R,20S-heptamethyl-22-[octahydro-5'S-[1R-hydroxyethyl]-2S,5'-dimethyl[2,2'R-bifura... |
| Anwendung: | Calcium ionophore |
| CAS | 56092-82-1 |
| MW: | 747.1 D |
ab 58,00 €
CHIR99021
Artikelnummer: Cay13122-10
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.763...
| Schlagworte: | CT 99021,... |
| Anwendung: | GSK3alpha and GSK3beta inhibitor |
| CAS | 252917-06-9 |
| MW: | 465.3 D |
ab 53,00 €
Thapsigargin
Artikelnummer: Cay10522-1
Thapsigargin is an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50 = ~30 nM for the rat liver microsomal enzyme), an ER stress inducer, and a sesquiterpene lactone that has been found in Thapsia. It increases intracellular calcium levels in isolated rat hepatocytes (EC50 = ~80 nM) and...
| Schlagworte: | (3S,3aS,4R,6R,7S,8R)-6-acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-2,3,3a... |
| Anwendung: | SERCA inhibitor |
| CAS | 67526-95-8 |
| MW: | 650.8 D |
ab 89,00 €
Bluo-Gal, pure
Artikelnummer: 50375.1
5-Bromo-3-Indolyl-ß-D-Galactopyranoside (Bluo-Gal) is a substrate for the histochemical localization of ß-galactosidase. Bluo-Gal is an alternative to X-Gal, producing a darker blue color.
| Schlagworte: | 5-Bromo-3-indolyl beta-D-galactopyranoside |
| Anwendung: | beta-Galactosidase substrate |
| CAS | 97753-82-7 |
| MW: | 374.20 |
295,00 €
NADH, disodium salt
Artikelnummer: 16132.1
Assay: >85% enzymatically
| Schlagworte: | beta-Nicotinamide-adenine-dinucleotide, reduced Na2-salt |
| CAS | 606-68-8 |
| MW: | 709.4 D |
ab 105,00 €