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Biochemikalien

Hier finden Sie ein breites Portfolio von Biochemikalien: Inhibitoren, Liganden und Substrate diverser Enzyme und Rezeptoren, Regulatoren, Assay Komponenten und Farbstoffe. Außerdem finden Sie in dieser Kategorie verschiedene Saccharide, Aminosäuren, Antioxidantien sowie diverse weitere Reagenzien für die biochemische Arbeit.

Hier finden Sie ein breites Portfolio von Biochemikalien: Inhibitoren, Liganden und Substrate diverser Enzyme und Rezeptoren, Regulatoren, Assay Komponenten und Farbstoffe. Außerdem finden Sie in... mehr erfahren »
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Biochemikalien

Hier finden Sie ein breites Portfolio von Biochemikalien: Inhibitoren, Liganden und Substrate diverser Enzyme und Rezeptoren, Regulatoren, Assay Komponenten und Farbstoffe. Außerdem finden Sie in dieser Kategorie verschiedene Saccharide, Aminosäuren, Antioxidantien sowie diverse weitere Reagenzien für die biochemische Arbeit.

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Cal-590(TM)-Dextran Conjugate *MW 10,000*
Cal-590(TM)-Dextran Conjugate *MW 10,000*

Artikelnummer: ABD-20509

Calcium measurement is critical for numerous biological investigations. Fluorescent probes that show spectral responses upon binding calcium have enabled researchers to investigate changes in intracellular free calcium concentrations by using fluorescence microscopy, flow cytometry, fluorescence spectroscopy and...
Anwendung: IF, FC
319,00 €
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Vulpinic Acid
Vulpinic Acid

Artikelnummer: Cay21685-100

Vulpinic acid is a lichen metabolite that has been found in L. vulpina and has diverse biological activities. It is active against C. perfringens, B. vulgatus, B. fragilis, B. loescheii, P. acnes, E. faecium, and methicillin-susceptible and -resistant S. aureus (MICs = 4-16 µg/ml). Vulpinic acid (25-800 µM) prevents...
Schlagworte: NSC 5897, alphaE-(3-hydroxy-5-oxo-4-phenyl-2(5H)-furanylidene)-benzeneacetic acid, methyl ester
Anwendung: Bioactive lichen metabolite
CAS 521-52-8
MW: 322.3 D
ab 32,00 €
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Thymohydroquinone
Thymohydroquinone

Artikelnummer: Cay27558-10

Thymohydroquinone is a quinone that has been found in N. sativa seeds and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) free radicals in a cell-free assay (IC50 = 2.4 µg/ml) and has a Trolox equivalent value of 2.6 in an oxygen radical absorbance capacity (ORAC)...
Schlagworte: NSC 34803, 2-methyl-5-(1-methylethyl)-1,4-benzenediol
Anwendung: Bioactive quinone
CAS 2217-60-9
MW: 166.2 D
ab 32,00 €
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NEU
AR-C 155858
AR-C 155858

Artikelnummer: Cay14884-1

AR-C 155858 is an inhibitor of monocarboxylate transporter 1 (MCT1) and MCT2 (Kis = 2.3 and Xenopus oocytes expressing the human receptors). It is selective for MCT1 and MCT2 over MCT4 (Ki = >10 µM). AR-C 155858 inhibits L-lactate uptake in and proliferation of murine 4T1 breast cancer cells (IC50s = 25 and 20.2 nM,...
Schlagworte: 6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-thieno[...
Anwendung: Monocarboxylate transporter 1/2 inhibitor
CAS 496791-37-8
MW: 461.5 D
374,00 €
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NEU
KT185
KT185

Artikelnummer: Cay19113-50

KT185 is an orally bioavailable inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 0.21 nM in a competitive activity-based protein profiling assay using Neuro2A membranes. It inhibits ABHD6 in a 2-arachidonoyl glycerol (2-AG, Cay-62160) hydrolysis assay (IC50 = 13.6 nM for...
Schlagworte: [4'-[1-[(2-phenyl-1-piperidinyl)carbonyl]-1H-1,2,3-triazol-4-yl][1,1'-biphenyl]-3-yl]-1-piperidinyl-methanone
Anwendung: ABHD6 inhibitor
CAS 1472640-86-0
MW: 519.6 D
ab 94,00 €
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NEU
Diclofenac amide
Diclofenac amide

Artikelnummer: Cay21969-500

Diclofenac amide is a prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Cay-70680, Cay-22983). It decreases paw thickness in a rat model of carrageenan-induced paw edema when administered at a dose of 100 µmol/kg and decreases acetic acid-induced writhing in mice at 100 µmol/kg. Diclofenac...
Schlagworte: 1-(2,6-Dichlorophenyl)oxindole, Diclofenac Lactam, NSC 621845, 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one
Anwendung: NSAID prodrug
CAS 15362-40-0
MW: 278.1 D
ab 35,00 €
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NEU
6-OHDA (hydrobromide)
6-OHDA (hydrobromide)

Artikelnummer: Cay25330-1

6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra,...
Schlagworte: 2,4,5-Trihydroxyphenethylamine, 6-hydroxy Dopamine, Oxidopamine, 5-(2-aminoethyl)-1,2,4-benzenetriol, monohydrobromide
Anwendung: Catecholaminergic neurotoxin
CAS 636-00-0
MW: 250.1 D
435,00 €
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NEU
(±)-trans-GK563
(±)-trans-GK563

Artikelnummer: Cay25732-5

trans-(±)-GK563 is a potent beta-lactone inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (GVIA iPLA2, IC50 = 1 nM). It is selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 µM). trans-(±)-GK563 (1 and 10 µM) inhibits apoptosis induced by IL-1beta and IFN-gamma in INS-1 beta-cells.
Schlagworte: GK563, (3R,4R)-rel-3-(4-phenylbutyl)-4-propyl-2-oxetanone
Anwendung: IPLA2beta inhibitor
CAS 2351820-19-2
MW: 246.3 D
ab 94,00 €
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NEU
TP-238 (hydrochloride)
TP-238 (hydrochloride)

Artikelnummer: Cay27254-5

TP-238 is a chemical probe for the bromodomains of cat eye syndrome chromosome region, candidate 2 (CECR2) and bromodomain PHD finger transcription factor (BPTF). It has on-target biochemical activity with CECR2 when used at concentrations ranging from 10 to 30 nM and with BPTF at concentrations ranging from 100 to...
Schlagworte: N-(3-(1H-pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine, hydrochloride
Anwendung: Chemical CECR2 & BPTF bromodomain probe
MW: 49.5 D
ab 95,00 €
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NEU
Melanotan II (acetate)
Melanotan II (acetate)

Artikelnummer: Cay27316-5

Melanotan II is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (Kis = 0.67, 34, 6.6, and 46 nM, respectively, in COS cells expressing human recombinant receptors). It improves recovery of sciatic nerve function after mechanical injury in rats, and increases cisplatin-induced decreases in sensory...
Schlagworte: MT II, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide, (2->7)-lactam,...
Anwendung: Melanocortin receptor (MC1R, MC3R, MC4R, MC5R) agonist
MW: 1024.2 D
ab 157,00 €
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NEU
BMS 779788
BMS 779788

Artikelnummer: Cay27339-5

BMS 779788 is a partial agonist of liver X receptor alpha (LXRalpha) and LXRbeta (Kis = 68 and 14 nM, respectively, in a radioligand binding assay). It activates LXRalpha and LXRbeta with EC50 values of 230 and 250 nM, respectively, in a transactivation assay. BMS 779788 increases expression of ATP-binding cassette...
Schlagworte: 2-[1-(2-chlorophenyl)-1-methylethyl]-alpha,alpha-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-1H-imidazole-4-methanol
Anwendung: LXR alpha & beta partial agonist
CAS 918348-67-1
MW: 509.1 D
ab 57,00 €
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NEU
Des(benzylpyridyl) Atazanavir
Des(benzylpyridyl) Atazanavir

Artikelnummer: Cay27372-5

Des(benzylpyridyl) atazanavir is a major metabolite of the HIV-1 protease inhibitor atazanavir (Cay-11733). It is formed from atazanavir by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2D6.
Schlagworte: Atazanavir metabolite M1,...
Anwendung: Major metabolite
CAS 1192224-24-0
MW: 537.7 D
ab 99,00 €
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