Recombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b (C-6His)

Recombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b (C-6His)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-32-8419-10 10 µg - -

3 - 11 Werktage*

478,00 €
ABE-32-8419-50 50 µg - -

3 - 11 Werktage*

791,00 €
 
Source: Human Cells. MW :26.2kD. Recombinant Human Tumor Necrosis Factor Receptor II is produced... mehr
Produktinformationen "Recombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b (C-6His)"
Source: Human Cells. MW :26.2kD. Recombinant Human Tumor Necrosis Factor Receptor II is produced by our Mammalian expression system and the target gene encoding Leu23-Asp257 is expressed with a 6His tag at the C-terminus. Tumor necrosis factor receptor superfamily member 1B is a 461 amino acids protein that belongs to the TNFR (tumor necrosis factor receptor) superfamily characterized by cysteine-rich extracellular domains. It contains 4 TNFR-Cys repeats. TNFRII is expressed in fetal brain. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Protein function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. [The UniProt Consortium]
Hersteller: Abeomics
Hersteller-Nr: 32-8419

Eigenschaften

Konjugat: No

Handhabung & Sicherheit

Lagerung: +20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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