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19(S)-HETE
Artikelnummer: Cay10007766-25
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively. Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels. 19(S)-HETE stimulates both...
| Anwendung: | Bioactive lipid assays |
| CAS | 115461-40-0 |
| MW: | 320.5 D |
| Reinheit: | >98% |
| Format: | Solution |
ab 150,00 €
Resolvin D1
Artikelnummer: Cay10012554-25
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and...
| Anwendung: | Bioactive lipid assays |
| CAS | 872993-05-0 |
| MW: | 376.5 D |
| Reinheit: | >95% |
| Format: | Solution |
ab 157,00 €
(±)11(12)-DiHET
Artikelnummer: Cay51511-25
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. (±)11(12)-DiHET relaxes U-46619 (Cay-16450)-contracted artery rings with approximately 70% of the magnitude of (±)11(12)-EET (Cay-50511).
| Anwendung: | Bioactive lipid studies |
| MW: | 338.5 D |
| Reinheit: | >98% |
| Format: | Solution |
ab 93,00 €
Resolvin D2
Artikelnummer: Cay10007279-10
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D2 (RvD2) is produced physiologically from the sequential oxygenation of DHA by 15- and...
| Anwendung: | Lipid mediator |
| CAS | 810668-37-2 |
| MW: | 376.5 D |
| Reinheit: | >95% |
| Format: | Solution |
ab 157,00 €
Leukotriene B4
Artikelnummer: Cay20110-50
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10-10 M), LTB4 causes chemotaxis and chemokinesis...
| Anwendung: | Bioactive lipid assays |
| CAS | 71160-24-2 |
| MW: | 336.5 D |
| Reinheit: | >97% |
| Format: | Solution |
ab 148,00 €
Leukotriene D4
Artikelnummer: Cay20310-25
LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by gamma-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is equipotent...
| Anwendung: | Bioactive lipid assays |
| CAS | 73836-78-9 |
| MW: | 496.7 D |
| Reinheit: | >97% |
| Format: | Solution |
ab 148,00 €
Lipoxin A4
Artikelnummer: Cay90410-25
Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Cay-34700) or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (Cay-20110) in inducing superoxide generation in human neutrophils at 0.1 µM. LXA4 is associated with several other biological functions including leukocyte activation,...
| Anwendung: | Bioactive lipid assays |
| CAS | 89663-86-5 |
| MW: | 352.5 D |
| Reinheit: | >95% |
| Format: | Solution |
ab 207,00 €
(R)-Bromoenol lactone
Artikelnummer: Cay10006800-1
The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral,...
| Anwendung: | IPLA2gamma inhibitor |
| CAS | 478288-90-3 |
| MW: | 317.2 D |
| Reinheit: | >98% |
| Format: | Solution |
ab 32,00 €
Leukotriene C4
Artikelnummer: Cay20210-25
Leukotriene C4 (LTC4) is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity....
| Anwendung: | Bioactive lipid assays |
| CAS | 72025-60-6 |
| MW: | 625.8 D |
| Reinheit: | >97% |
| Format: | Solution |
ab 137,00 €
2-Arachidonoyl Glycerol-d5
Artikelnummer: Cay362162-100
2-Arachidonoyl glycerol-d5 (2-AG-d5) contains five deuterium atoms at the 1, 1, 2, 3, and 3 positions of the glycerol moiety. It is intended for use as an internal standard for the quantification of 2-AG by GC- or LC-mass spectrometry. 2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the CB1 receptor. Unlike anandamide, 2-AG is present at relatively high levels in...
| Anwendung: | Standard |
| MW: | 383.6 D |
| Reinheit: | >99% deuterated forms (d1-d5) |
| Format: | Solution |
ab 65,00 €
Maresin 1
Artikelnummer: Cay10878-10
Docosahexaenoic acid (DHA, Cay-90310) is an omega-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development. Maresin 1 (7(R)-MaR1) is a 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A. It potently reduces infiltration of neutrophils...
| Anwendung: | Inflammation studies |
| CAS | 1268720-28-0 |
| MW: | 360.5 D |
| Reinheit: | >95% |
| Format: | Solution |
ab 78,00 €
4-hydroxy Nonenal
Artikelnummer: Cay32100-1
4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized omega-6 polyunsaturated fatty acids such as arachidonic acid. 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. 4-hydroxy Nonenal inhibits...
| Anwendung: | Lipid peroxidation studies |
| CAS | 75899-68-2 |
| MW: | 156.2 D |
| Reinheit: | >98% |
| Format: | Solution |
ab 63,00 €
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