Produkte von SYNkinase

SYNkinase

SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkt zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind in der pharmazeutischen Wirkstoffforschung seit drei Jahrzehnten tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und Unternehmensvorständen.

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SAR-020106
SAR-020106

Artikelnummer: SYN-1189-M001

Soluble in DMSO. SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a...
Anwendung: Chk1 inhibitor
CAS 1184843-57-9
MW: 382,9 D
Reinheit: >95%
Format: Solid
ab 250,00 €
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SB203580
SB203580

Artikelnummer: SYN-1074-M005

Soluble in DMSO or ethanol. SB203580 is a specific, ATP competitive, cell-permeable inhibitor of p38 MAPK with IC(50) of 0.3-0.5µM. It is 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC(50) of 3-5µM. Target: p38 | Kinase Group: CMGC | Substrate: Serine-Threonine
Anwendung: P38 inhibitor
CAS 152121-47-6
MW: 377,4 D
Reinheit: >95%
Format: Solid
ab 66,00 €
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GW-806742X
GW-806742X

Artikelnummer: SYN-1215-M001

Soluble in DMSO. Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited TSQ-induced death of mouse dermal fibroblasts by delaying MLKL...
Anwendung: VEGFR2 inhibitor
CAS 579515-63-2
MW: 573,6 D
Reinheit: >95%
Format: Solid
ab 119,00 €
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SP2509
SP2509

Artikelnummer: SYN-1212-M001

Soluble in DMSO. LSD1 is a promising target for cancer therapy. Epigenetic control of histone methylation is frequently associated with oncogenesis and LSD1 is overexpressed in many types of cancer. siRNA knockdown of LSD1 has been shown to suppress growth of cancer cells. SP-2528 is a selective and reversible LSD1 inhibitor with an IC(50) of 10nM. SP-2528 demonstrates a...
Anwendung: LSD1 inhibitor
CAS 1423715-09-6
MW: 437,9 D
Reinheit: >95%
Format: Solid
ab 158,00 €
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PD-0325901
PD-0325901

Artikelnummer: SYN-1059-M005

Soluble in DMSO or ethanol. PD0325901 is selective and non ATP-competitive MEK inhibitor with an IC(50) of 0.33nM, roughly 500-fold more potent than CI-1040 on the phosphorylation of ERK1 and ERK2. Target: MEK | Kinase Group: STE | Substrate: Serine-Threonine
Anwendung: MEK inhibitor
CAS 391210-10-9
MW: 482,2 D
Reinheit: >95%
Format: Solid
ab 66,00 €
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Vorinostat
Vorinostat

Artikelnummer: SYN-3006-M005

Solid. Soluble in DMSO or ethanol. Almost insoluble in water. Vorinostat (SAHA, MK0683, Zolinza) inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50< 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there...
Anwendung: HDAC inhibitor
CAS 149647-78-9
MW: 264,3 D
Reinheit: >95%
Format: Solid
ab 53,00 €
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Sildenafil citrate
Sildenafil citrate

Artikelnummer: SYN-3016-M005

Soluble in DMSO or ethanol. Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). Target: PDE5
Anwendung: PDE5 inhibitor
CAS 171599-83-0
MW: 666,7 D
Reinheit: >95%
Format: Solid
ab 66,00 €
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AZD-8055
AZD-8055

Artikelnummer: SYN-1166-M100

Soluble in DMSO or ethanol. AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase activity with an IC(50) of 0.8nM. It shows excellent selectivity (~1,000-fold) against all class I phosphatidylinositol 3-kinase (PI3K) isoforms and other members of the PI3K-like kinase family. Target: mTOR | Kinase Group: Atypical (PIKK) | Substrate: Serine-Threonine
Anwendung: MTOR inhibitor
CAS 1009298-09-2
MW: 465,5 D
Reinheit: >95%
Format: Solid
ab 79,00 €
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Rapamycin
Rapamycin

Artikelnummer: SYN-1185-M010

Soluble in DMSO or ethanol. Rapamycin is a specific mTOR inhibitor with an IC(50) of ~0.1nM. Target: mTOR | Kinase Group: Atypical (PIKK) | Substrate: Serine-Threonine
Anwendung: MTOR inhibitor
CAS 53123-88-9
MW: 914,2 D
Reinheit: >95%
Format: Solid
ab 66,00 €
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GSK-1120212
GSK-1120212

Artikelnummer: SYN-1170-M010

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC(50) values of 0.92nM and 1.8nM respectively. Target: MEK1 - MEK2 | Kinase Group: STE | Substrate: Serine-Threonine
Anwendung: MEK1 / MEK2 inhibitor
CAS 871700-17-3
MW: 615,4 D
Reinheit: >95%
Format: Solid
ab 106,00 €
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ABT-737
ABT-737

Artikelnummer: SYN-1001-M001

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death...
Anwendung: Bcl-2 / Bcl-X(L) / Bcl-w inhibitor
CAS 852808-04-9
MW: 813,4 D
Reinheit: >95%
Format: Solid
ab 79,00 €
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H1152
H1152

Artikelnummer: SYN-1221-M001

Solid. Soluble in DMSO. H-1152 is a potent, specific, ATP-competitive and cell permeable ROCK inhibitor, with an IC50 of 12nM for ROCKII. H-1152 poorly inhibits PKA, PKC and myosin light chain kinase. Rho kinase (ROCK) activated by GTP-linked Rho phosphorylates targets that are involved in cytoskeletal remodelling, smooth muscle contraction and neuronal development.
Anwendung: Cell-permeable ROCK inhibitor
CAS 871543-07-6
MW: 392,3 D
Reinheit: >95%
Format: Solid
ab 106,00 €
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