GR94800

GR94800 is a synthetic peptide neurokinin-2 (NK2) receptor antagonist (Ki = 1 nM). It is selective for NK2 over NK3 (Ki = 1,000 nM). GR94800 (0.1 and 1 µM) decreases balloon distension-induced submaximal and maximal atropine-resistant ascending excitatory reflex (AER) in isolated guinea pig ileum circular muscles.Formal Name: N-benzoyl-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl-L-prolyl-L-norleucinamide. CAS Number: 141636-65-9. Synonyms: Benzoyl-Ala-Ala-trp-Phe-pro-Pro-Nle-NH2, GR98400. Molecular Formula: C49H61N9O8. Formula Weight: 904.1. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: X-AAwFpPZ-NH2 (X = Benzoyl, Z = Norleucine). Solubility: Acetonitrile: Soluble. SMILES: O=C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](C(N3CCC[C@H]3C(N[C@@H](CCCC)C(N)=O)=O)=O)CCC2)=O)[C@H](NC([C@H](C)NC([C@H](C)NC(C4=CC=CC=C4)=O)=O)=O)CC5=CNC6=CC=CC=C56. InChi Code: InChI=1S/C49H61N9O8/c1-4-5-21-37(42(50)59)54-47(64)40-23-14-25-57(40)49(66)41-24-15-26-58(41)48(65)39(27-32-16-8-6-9-17-32)56-46(63)38(28-34-29-51-36-22-13-12-20-35(34)36)55-44(61)31(3)52-43(60)30(2)53-45(62)33-18-10-7-11-19-33/h6-13,16-20,22,29-31,37-41,51H,4-5,14-15,21,23-28H2,1-3H3,(H2,50,59)(H,52,60)(H,53,62)(H,54,64)(H,55,61)(H,56,63)/t30-,31-,37-,38+,39-,40-,41+/m0/s1. InChi Key: CWEISCOCKRHHOU-UJYVDGJVSA-N.