Sonstige Peptide

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Gly-Phe-beta-naphthylamide
Gly-Phe-beta-naphthylamide

Artikelnummer: Cay14634-100

Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates. Aside from its role in post-translational processing, cathepsins may also participate in apoptotic signaling pathways by targeting cytosolic caspases...
Schlagworte: H-Gly-Phe-BNA, glycyl-N-2-naphthalenyl-L-phenylalaninamide
Anwendung: Cathepsin C substrate
CAS 21438-66-4
MW: 347.4 D
ab 57,00 €
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Malformin C
Malformin C

Artikelnummer: Cay21613-1

Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin (Cay-13877) to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates...
Schlagworte: Malformin B1b, cyclo(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-leucyl), cyclic (1->2)-disulfide
Anwendung: Antibacterial
CAS 59926-78-2
MW: 529.7 D
ab 232,00 €
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L-Leucyl-L-Leucine methyl ester (hydrochloride)
L-Leucyl-L-Leucine methyl ester (hydrochloride)

Artikelnummer: Cay16008-1

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid...
Schlagworte: LLME, LLOMe, L-leucyl-L-leucine, methyl ester, monohydrochloride
Anwendung: Specific cytotoxin
CAS 6491-83-4
MW: 294.8 D
ab 32,00 €
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Peptide YY (3-36)
Peptide YY (3-36)

Artikelnummer: Cay16502-1

Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite. PYY, along with neuropeptide Y (NPY, Cay-15071), inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate...
Schlagworte: Pancreatic Peptide YY, Peptide Tyrosine Tyrosine
Anwendung: Building block, Click Chemistry
CAS 126339-09-1
MW: 4049.5 D
ab 207,00 €
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Glucagon
Glucagon

Artikelnummer: Cay24204-1

Glucagon is a peptide hormone produced from proglucagon in pancreatic alpha cells that has a role in the regulation of glucose metabolism. Pulsatile application of glucagon to rat hepatocytes stimulates glucose production ex vivo. It also stimulates glucose output from perfused rat livers via increases in...
Schlagworte: glucagon (swine)
Reaktivität: Swine
CAS 16941-32-5
MW: 3482.8 D
ab 82,00 €
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MeOSuc-AAPV-pNA
MeOSuc-AAPV-pNA

Artikelnummer: Cay17601-10

Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to...
Schlagworte: N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-valinamide
Anwendung: Neutrophil elastase & PR3 substrate
CAS 70967-90-7
MW: 590.6 D
ab 32,00 €
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Z-VAD(OMe)-FMK
Z-VAD(OMe)-FMK

Artikelnummer: Cay14463-1

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 µM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in...
Schlagworte: Z-Val-Ala-Asp-(OMe)-Fluoromethyl Ketone,...
Anwendung: Caspase inhibitor
CAS 187389-52-2
MW: 467.5 D
ab 124,00 €
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Orexin A (bovine, human, mouse, rat)
Orexin A (bovine, human, mouse, rat)

Artikelnummer: Cay15073-500

Orexin A is a 33 amino acid hypothalamic neuropeptide with a role in appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds. Orexin signaling is activated by nutrient depletion, causing an increase in food intake by delaying the signals of satiety. It...
Schlagworte: Hypocretin-1, Hcrt1
Anwendung: HCRTR1/2 Ox1R / Ox2R ligand
CAS 205640-90-0
MW: 3561.1 D
ab 294,00 €
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3,3',5'-Triiodo-L-thyronine
3,3',5'-Triiodo-L-thyronine

Artikelnummer: Cay17598-25

3,3',5'-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRalpha and TRbeta than 3,3',5-triiodo-L-thyronine (Cay-16028) and commonly described as inactive. However, high...
Schlagworte: 3,3',5'-T3, Reverse T3, rT3, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine
Anwendung: TR Delta alpha1 activator
CAS 5817-39-0
MW: 651 D
ab 82,00 €
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Angiotensin II (human)
Angiotensin II (human)

Artikelnummer: Cay17150-25

Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two...
Schlagworte: 5-L-isoleucine-angiotensin II
Anwendung: Peptide hormone
CAS 4474-91-3
MW: 1046.2 D
ab 24,00 €
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Q-VD-OPH
Q-VD-OPH

Artikelnummer: Cay15260-1

Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 µM. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK (Cay-14463) and Boc-D-FMK (Cay-16118). Q-VD-OPH can be used in vivo, where it has been shown to...
Schlagworte: Quinoline-Val-Asp-Difluorophenoxymethyl Ketone,...
Anwendung: Caspase inhibitor, Apoptosis inhibitor
CAS 1135695-98-5
MW: 513.5 D
ab 124,00 €
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CCK Octapeptide (non-sulfated)
CCK Octapeptide (non-sulfated)

Artikelnummer: Cay24404-500

Cholecystokinin (CCK) octapeptide is a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. It is a cleavage product of the full CCK preprohormone. CCK octapeptide (non-sulfated) has 1/300th of the activity of sulfated CCK octapeptide.
Schlagworte: Cholecystokinin (CCK) (26-33), 2-desulfo-cholecystokinin-8 (swine)
Anwendung: Peptide hormone
CAS 25679-24-7
MW: 1063.2 D
ab 35,00 €
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