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Ac-DEVD-AFC
Artikelnummer: ABD-13401
A fluorogenic substrate for caspase 3. The 7-amido-4-trifluoromethylcoumarin derivatives have better membrane permeability than the 7-amido-4-methylcoumarin derivatives.
| Anwendung: | Caspase-3 substrate |
| CAS | 201608-14-2 |
145,00 €
Ac-DEVD-AMC
Artikelnummer: ABD-13402
A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
| Anwendung: | Caspase-3 substrate |
| CAS | 169332-61-0 |
145,00 €
(Z-DEVD)2-R110
Artikelnummer: ABD-13430
Cleavage of R110 peptides by caspases generates strongly fluorescent R110 that can be monitored fluorimetrically at 510-530 nm with excitation of 488 nm.This R110 substrate is specific for caspases 3 and 7.
| Anwendung: | Caspase-3 substrate, Caspase-7 substrate |
145,00 €
(Ac-PAL)2R110
Artikelnummer: ABD-13467
The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...
| Anwendung: | Protease substrate |
145,00 €
PI-3 Kinase Lipid Substrate
Artikelnummer: BPS-40560
PI/PS (4:1, w/w) unilamellar vesicle, prepared with L-alpha-phosphatidylinositol (Liver, Bovine) (sodium salt) and L-alpha-phosphatidylserine (Brain, Porcine) (sodium salt). Lipid monolayer was formed by sonication. Application: Useful as a substrate for PI-3 kinase activity assays and other lipid kinases....
| Anwendung: | PI-3 kinase substrate |
581,00 €
(BOC-VPR)2R110
Artikelnummer: ABD-13462
(BOC-VPR)2R110 is a sentive fluorogenic substrate for alpha-thrombin. The non-fluorescent substrate generates a bright green fluorescent R110 product that has Ex/Em = 495/520 nm, and can be easily detected with the FITC filter set. This substrate has also been used for the rapid detection of MRSA...
| Anwendung: | Fluorogenic alpha-thrombin substrate |
145,00 €
MeOSuc-AAPV-pNA
Artikelnummer: Cay17601-10
Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to...
| Schlagworte: | N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-valinamide |
| Anwendung: | Neutrophil elastase & PR3 substrate |
| CAS | 70967-90-7 |
| MW: | 590.6 D |
ab 97,00 €
(Ac-WLA)2R110
Artikelnummer: ABD-13468
The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...
| Anwendung: | Protease substrate |
145,00 €
Bortezomib
Artikelnummer: Cay10008822-1
Bortezomib is a dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM). It binds the beta5-subunit of the 20S proteasome and selectively inhibits chymotryptic activity. In part by blocking the degradation of tumor-suppressing and proapoptotic proteins, bortezomib drives cell...
| Schlagworte: | LDP-341, MG-341, MLN341, NSC 681239, PS-341,... |
| Anwendung: | Proteasome subunit beta type-1/5 inhibitor |
| CAS | 179324-69-7 |
| MW: | 384.2 D |
ab 53,00 €
Pepstatin
Artikelnummer: LKT-P1761.25
An inhibitor of acid proteases isolated from streptomyces. It has been shown to induce contractile effects on rat aorta rings.
| Schlagworte: | Pepstatin A |
| Anwendung: | Aspartyl Protease inhibitor |
| CAS | 26305-03-3 |
| MW: | 685,89 D |
ab 127,00 €
Z-VDVAD-FMK
Artikelnummer: Cay17484-1
Z-VDVAD-FMK is a peptide caspase-2 inhibitor. Intravitreal injection of Z-VDVAD-FMK (4,000 ng/ml) reduces optic nerve crushing-induced retinal ganglion cell apoptosis in rats. It also prevents endothelial cell apoptosis in a dog model of subarachnoid hemorrhage-induced chronic cerebral vasospasm. InChI:...
| Schlagworte: | Z-Val-Asp-(OMe)-Val-Ala-Asp-(OMe)-FMK, Z-VDVAD-Fluoromethyl Ketone,... |
| Anwendung: | Caspase-2 peptide inhibitor |
| CAS | 210344-92-6 |
| MW: | 695.7 D |
ab 147,00 €
Z-VEID-FMK
Artikelnummer: Cay44015-1
Z-VEID-FMK is a peptide inhibitor of caspase-3 and -6 (apparent IC50s = 45. and 128. nM, respectively). It decreases lamin cleavage induced by caspase-6 in a cell-free assay (IC50 = 45 µM). Z-VEID-FMK (160 µM) decreases apoptosis in primary human erythroblasts cultured in erythropoietin-deficient media. It increases...
| Schlagworte: | Cbz-Val-Glu(OMe)-Ile-Asp(OMe)-CH2F, methyl... |
| Anwendung: | Caspase-3 / caspase-6 peptide inhibitor |
| CAS | 210344-96-0 |
| MW: | 652.72 D |
ab 186,00 €