Produkte von LC Laboratories

LC Laboratories

LC Laboratories aus Woburn, Massachusetts, liefert seit 1980 Small Molecules für die Forschung. Zahlreiche Hersteller von Reagenzien verkaufen die hochwertigen Produkte von LC Laboratories unter ihrem eigenen Label. Wenn Sie im Bereich Signaltransduktion, Onkologie oder anderer präklinischer Forschung unterwegs sind, haben Sie sich wahrscheinlich von Anfang an, bewußt oder unbewußt, auf LC Labs-Produkte verlassen.

Mehr unter: www.lclabs.com

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Neratinib, Free Base
Neratinib, Free Base

Artikelnummer: LC-N-6404_100mg

Solubility: Soluble in DMSO at 2 mg/mL with warming, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Neratinib, also known as HKI-272, is considered to...
Schlagworte: HKI-272
Anwendung: EGFR/ ERBB2 inhibitor
CAS 698387-09-6
MW: 557,04 D
ab 62,00 €
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Enasidenib, Free Base
Enasidenib, Free Base

Artikelnummer: LC-E-2121_5mg

Soluble in DMSO. Enasidenib, also known as AG221, is a potent and selective IDH2 mutant enzyme inhibitor. It caused a significant decrease in R(-)-2-hydroxyglutarate in marrow, plasma, and urine and showed a dose-dependent survival benefit in a primary human AML xenograft model carrying the IDH2 R140Q mutation. Wang...
Schlagworte: AG221
Anwendung: Antineoplastic, Potent, selective IDH2 mutant enzyme inhibitor
CAS 1446502-11-9
MW: 473.38 D
ab 72,00 €
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Osimertinib, Methanesulfonate Salt
Osimertinib, Methanesulfonate Salt

Artikelnummer: LC-O-7233_25mg

Soluble in DMSO. This research compound is the methanesulfonate salt form of osimertinib. Osimertinib, also known as AZD9291, is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). EGFR TKIs have been used to treat patients with non-small-cell lung cancer (NSCLC) harboring sensitizing...
Schlagworte: AZD9291, Mereletinib
Anwendung: Antineoplastic, EGFR tyrosine kinase inhibitor
CAS 1421373-66-1
MW: 595.72 D
ab 76,00 €
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Cabazitaxel (Jevtana, RPR-116258, Taxoid XRP6258, TXD-258, XRP-6258, CAS 183133-96-2), >99%
Cabazitaxel (Jevtana, RPR-116258, Taxoid XRP6258,...

Artikelnummer: LC-C-2581_100mg

Soluble in DMSO at 100 mg/mL, soluble in ethanol at 50 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 1-2 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
Schlagworte: beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-benzenepropanoic acid,...
Anwendung: Tubulin depolymerization inhibitor
CAS 183133-96-2
MW: 835,93 D
ab 78,00 €
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Ibrutinib, Free Base
Ibrutinib, Free Base

Artikelnummer: LC-I-3311_100mg

Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 25 mg/mL with slight warming. Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM...
Schlagworte: CRA-032765, PCI-32765, PCI-32765-00
Anwendung: Selective, irreversible Bruton's tyrosine kinase (BTK) inhibitor
CAS 936563-96-1
MW: 440.5 D
ab 74,00 €
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Vandetanib, Free Base
Vandetanib, Free Base

Artikelnummer: LC-V-9402_100mg

Solubility: Soluble in DMSO at 30 mg/mL, soluble in ethanol at 10 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Vandetanib inhibits VEGFR-dependent tumor...
Schlagworte: ZD6474
Anwendung: VEGFR / EGFR Kinase inhibitor
CAS 443913-73-3
MW: 475,35 D
ab 82,00 €
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Temsirolimus
Temsirolimus

Artikelnummer: LC-T-8040_100mg

Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 200 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Temsirolimus, a rapamycin (sirolimus) derivative, also...
Schlagworte: CCI-779
Anwendung: Antineoplastic, MTOR inhibitor
CAS 162635-04-3
MW: 1030.29 D
ab 80,00 €
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Alectinib, Free Base
Alectinib, Free Base

Artikelnummer: LC-A-2300_100mg

Soluble in DMSO.. Alectinib, also known as CH 5424802, is a potent, selective, and orally available ALK inhibitor (IC50 = 1.9 nM) and has weak or no inhibition against 24 other tested protein kinases. It has selective antitumor activity against cancers with ALK gene alterations, including non-small cell lung cancer...
Schlagworte: CH 5424802
Anwendung: Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor
CAS 1256580-46-7
MW: 482.62 D
ab 83,00 €
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Acalabrutinib, Free Base
Acalabrutinib, Free Base

Artikelnummer: LC-A-7337_100mg

Soluble in DMSO. Acalabrutinib, also known as ACP-196, is an irreversible Bruton tyrosine kinase (BTK) inhibitor. It binds covalently to Cys481 with improved selectivity and in vivo target coverage. Acalabrutinib inhibited BTK with an IC50 of 3 nM and had improved target specificity over ibrutinib with 323-, 94-,...
Schlagworte: ACP196, ACP-196
Anwendung: Antineoplastic, Bruton's tyrosine kinase (BTK) inhibitor
CAS 1420477-60-6
MW: 465.51 D
ab 72,00 €
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Baricitinib, Free Base
Baricitinib, Free Base

Artikelnummer: LC-B-1600_100mg

Soluble in DMSO. Baricitinib, also known as INCB028050, is a janus kinase (JAK) inhibitor. It potently and selectively inhibited JAK1 and JAK2 kinases with IC50 values of 5.9 nM and 5.7 nM, respectively. It inhibited intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23, with IC50...
Schlagworte: NCB028050, LY3009104
Anwendung: Antiinflammatory, Antirheumatic, Immunosuppressant, Janus kinase (JAK) inhibitor
CAS 1187594-09-7
MW: 371.42 D
ab 71,00 €
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Brigatinib, Free Base
Brigatinib, Free Base

Artikelnummer: LC-B-9800_100mg

Soluble in DMSO. Brigatinib, also known as AP26113, inhibited ALK, IGF-1R, and InsR kinases with IC50 values of 0.37 nM, 24.9 nM, and 196 nM, respectively. It blocked the viability of Karpas 299 cells (ALK+) with an IC50 of 29 nM in vitro. It demonstrated efficacy in multiple ALK+ xenografts in mice, including...
Schlagworte: AP26113
Anwendung: Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor
CAS 1197953-54-0
MW: 584.09 D
ab 71,00 €
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Cobimetinib, Free Base
Cobimetinib, Free Base

Artikelnummer: LC-C-1100_100mg

Soluble in DMSO. Cobimetinib demonstrated a sustained tumor pharmacodynamic response due to longer residence times in tumor tissue than in plasma in mice. Following single doses, cobimetinib inhibited pERK in tumors with IC50 values of 780 nM in WM-266-4 and 520 nM in A375 xenograft mice. Following multiple doses,...
Schlagworte: GDC0973, RG7420, XL518
Anwendung: Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor
CAS 934660-93-2
MW: 531.31 D
ab 76,00 €
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