Zu "K04223" wurden 36 Artikel gefunden!
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GR87389
Artikelnummer: Cay44018-1
An NK2 receptor antagonist, inhibits NKA binding in rat hippocampal, urinary bladder, and duodenal membranes (Kis = 4, 5.2, and 14 nM, respectively), inhibits GR64349-induced contraction of isolated human detrusor muscle at 30, 100, and 300 nM. SMILES:...
| Schlagworte: | Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2,... |
| Anwendung: | NK2 receptor antagonist |
| CAS | 141663-86-7 |
| MW: | 900.09 D |
ab 78,00 €
GR83074 (trifluoroacetate salt)
Artikelnummer: Cay44017-1
GR83074 is a peptide antagonist of the neurokinin-2 (NK2) receptor. It selectively inhibits neurokinin A-induced contractions in rat colon muscularis mucosae, which express NK2 receptors, over substance P-induced contractions in guinea pig ileum longitudinal smooth muscle strips, which express NK1 receptors (pKbs =...
| Schlagworte: | Boc-Arg-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2,... |
| Anwendung: | NK2 receptor peptide antagonist |
| MW: | 985,2 D |
ab 153,00 €
R 396 (trifluoroacetate salt)
Artikelnummer: Cay43083-10
A peptide antagonist of the NK2B receptor (pA2 = 7.63), selective for the NK2B receptor over NK1, NK2A, and NK3 receptors (pA2s = <5, 5.41, and <5, respectively), intracerebroventricular administration inhibits NKA- but not substance P-induced increases in mean arterial blood pressure, heart rate, face washing, and...
| Schlagworte: | Ac-Leu-Asp-Gln-Trp-Phe-Gly-NH2, N-acetyl-L-leucyl-L-alpha-aspartyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl-glycinamide,... |
| Anwendung: | NK2B receptor peptide antagonist |
| MW: | 805.89 D |
ab 70,00 €
GR64349 (acetate)
Artikelnummer: Cay42915-1
A peptide agonist of the NK2 receptor, selectively induces contractions in isolated rat colon muscularis mucosae, which endogenously express NK2 receptors, over isolated guinea pig ileum longitudinal smooth muscle and everted rat portal vein, which endogenously express NK1 and NK3 receptors, respectively (EC50s =...
| Schlagworte: | [Lys3,Gly8-R-Lac-Leu9]Neurokinin A (3-10), [Lys3,Gly8-R-Lac-Leu9]NKA (3-10), [Lys3,Gly8-R-gamma-lactam-Leu9]NKA (3-10),... |
| Anwendung: | Peptide NK2 receptor (TAC2R, tachykinin receptor 2) agonist |
| MW: | 981.18 D |
ab 483,00 €
Human Neurokinin A / NK2R ELISA Kit
Artikelnummer: G-HUFI02889.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Mouse Neurokinin A / NK2R ELISA Kit
Artikelnummer: G-MOFI01133.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
698,00 €
Men 10376
Artikelnummer: LKT-M1752.1
An NK2 (tachykinin receptor 2) antagonist.
| Anwendung: | NK2 antagonist |
| MW: | 1081,25 D |
ab 114,00 €
MEN10376
Artikelnummer: Cay31142-1
MEN10376 is a peptide neurokinin-2 (NK2) receptor antagonist. It inhibits contractions induced by neurokinin A (NKA) in endothelium-deprived isolated rabbit pulmonary artery (pA2 = 8.08), which is endogenously enriched in NK2 receptors. It is selective for NK2 receptors in isolated rabbit pulmonary artery over NK2...
| Schlagworte: | Asp-Tyr-Trp-Val-Trp-Trp-Lys-NH2, DYWVWWK-NH2,... |
| Anwendung: | Neurokinin-2 (NK2) receptor antagonist |
| CAS | 135306-85-3 |
| MW: | 1081.2 D |
ab 105,00 €
GR159897
Artikelnummer: Cay32774-1
GR159897 is a nonpeptide antagonist of the neurokinin-2 (NK2) receptor. It binds to NK2 receptors (Ki = 0.32 nM) and is selective for NK2 over NK1 and NK3 receptors in radioligand binding assays (Kis = 5,010 and >1,000 nM, respectively). GR159897 inhibits contractions induced by the NK2 receptor agonist GR64349 in...
| Schlagworte: | 5-fluoro-3-[2-[4-methoxy-4-[[(R)-phenylsulfinyl]methyl]-1-piperidinyl]ethyl]-1H-indole |
| Anwendung: | Nonpeptide NK2 receptor antagonist |
| CAS | 158848-32-9 |
| MW: | 414.5 D |
ab 69,00 €
WIN 66,306
Artikelnummer: Cay33161-5
WIN 66,306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors (Kis = 8 and 3.8 µM, respectively, for the human receptors) and inhibits contractions induced by substance P (Cay-24035) in isolated guinea pig ileum in a...
| Schlagworte: | cyclo[glycyl-L-tryptophyl-L-prolylglycyl-L-valylglycyl-(betaR)-beta-hydroxy-3-(3-methyl-2-butenyl)-L-tyrosyl] |
| Anwendung: | TACR1 / TACR2 peptide antagonist |
| CAS | 151928-32-4 |
| MW: | 800.9 D |
ab 371,00 €
Anti-TACR2
Artikelnummer: ATA-HPA076573.100
Protein function: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. [The UniProt...
| Schlagworte: | Anti-SKR, Anti-NK2R, Anti-TACR2, Anti-NK-2R, Anti-NK-2 receptor, Anti-Substance-K receptor, Anti-Tachykinin receptor 2,... |
| Anwendung: | ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 369,00 €
GR94800
Artikelnummer: Cay38773-1
GR94800 is a synthetic peptide neurokinin-2 (NK2) receptor antagonist (Ki = 1 nM). It is selective for NK2 over NK3 (Ki = 1,000 nM). GR94800 (0.1 and 1 µM) decreases balloon distension-induced submaximal and maximal atropine-resistant ascending excitatory reflex (AER) in isolated guinea pig ileum circular...
| Schlagworte: | Benzoyl-Ala-Ala-trp-Phe-pro-Pro-Nle-NH2, GR98400,... |
| Anwendung: | NK2 receptor (tachykinin receptor 2, TACR2) antagonist, synthetic peptide |
| CAS | 141636-65-9 |
| MW: | 904.1 D |
ab 45,00 €