Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)

Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II (Cay-17150). It inhibits renin (Cay-10006217) release from rat kidney slices at a concentration of 50 µM and relaxes rat aorta pre-contracted with phenylephrine (Cay-17205, Cay-18619, EC50 = 0.28 µM). In vivo, microinjection of angiotensin II (5-8) into the ventrolateral periaqueductal gray (vlPAG) of rats increases mean arterial pressure (MAP) and decreases heart rate (HR) by approximately 2.7- and 3-fold less, respectively, than angiotensin II. It increases the latency to withdrawal in a tail-flick test and the mechanical withdrawal threshold in an incision allodynia test in rats when administered at a dose of 0.2 nmol into the vlPAG. Angiotensin II (5-8) (0.4 nmol, vlPAG microinjection) reduces the number of entries and time spent in the open arms of the elevated plus maze and increases the mean startle amplitude, a measure of conditioned fear, in response to foot shock.Formal Name: L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine, 2,2,2-trifluoroacetate. Synonyms: Angiotensin (5-8). Molecular Formula: C26H36N6O5 . XCF3COOH. Formula Weight: 512.6. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: C[C@@H](CC)[C@]([H])(N)C(N[C@@H](CC1=CNC=N1)C(N2[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CCC2)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C26H36N6O5.C2HF3O2/c1-3-16(2)22(27)24(34)30-19(13-18-14-28-15-29-18)25(35)32-11-7-10-21(32)23(33)31-20(26(36)37)12-17-8-5-4-6-9-17,3-2(4,5)1(6)7/h4-6,8-9,14-16,19-22H,3,7,10-13,27H2,1-2H3,(H,28,29)(H,30,34)(H,31,33)(H,36,37),(H,6,7)/t16-,19-,20-,21-,22-,/m0./s1. InChi Key: MMKHYJAANIHLKG-LORYADHZSA-N.