Angiotensinogen (1-14) (human) (trifluoroacetate salt)

Angiotensinogen (1-14), also known as tetradecapeptide (TDP), is a synthetic peptide precursor of angiotensin I (Cay-24737) that corresponds to amino acids 1-14 of endogenous human angiotensinogen. Angiotensinogen (1-14) is cleaved by renin at the Leu-Val peptide bond to release angiotensin I, which is then converted to angiotensin II (Cay-17150) by angiotensin converting enzyme (ACE) and exerts vasoconstrictive properties. Angiotensinogen (1-14) (0.001-1 µM) induces contraction of isolated rat femoral resistance vessels, an effect that is reduced by the angiotensin II receptor partial antagonist saralasin and enhanced by the serine protease kallikrein.Formal Name: L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-valyl-L-isoleucyl-L-histidyl-L-asparagine, trifluoroacetate salt. Molecular Formula: C83H122N24O19 . XCF3COOH. Formula Weight: 1760.0. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Formic Acid: 1 mg/ml. SMILES: [H]N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)CC2=CN=CN2)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)=O)CC5=CN=CN5)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O)CC(O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C83H122N24O19.C2HF3O2/c1-11-45(9)67(105-75(118)57(30-48-22-24-52(108)25-23-48)99-77(120)65(43(5)6)103-70(113)54(20-16-26-91-83(86)87)95-69(112)53(84)34-64(110)111)80(123)101-60(33-51-38-90-41-94-51)81(124)107-27-17-21-62(107)76(119)98-56(29-47-18-14-13-15-19-47)71(114)97-58(31-49-36-88-39-92-49)72(115)96-55(28-42(3)4)74(117)104-66(44(7)8)78(121)106-68(46(10)12-2)79(122)100-59(32-50-37-89-40-93-50)73(116)102-61(82(125)126)35-63(85)109,3-2(4,5)1(6)7/h13-15,18-19,22-25,36-46,53-62,65-68,108H,11-12,16-17,20-21,26-35,84H2,1-10H3,(H2,85,109)(H,88,92)(H,89,93)(H,90,94)(H,95,112)(H,96,115)(H,97,114)(H,98,119)(H,99,120)(H,100,122)(H,101,123)(H,102,116)(H,103,113)(H,104,117)(H,105,118)(H,106,121)(H,110,111)(H,125,126)(H4,86,87,91),(H,6,7)/t45-,46-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-,67-,68-,/m0./s1. InChi Key: VQLJUAMNBAEFFK-FBLPGADJSA-N.