[Ala1,3,11,15]-Endothelin-1 (trifluoroacetate salt)

[Ala1,3,11,15]-Endothelin-1 is an endothelin receptor type B (ETB) agonist and linear synthetic peptide derivative of endothelin-1 in which all four cysteine residues have been substituted with alanine. It selectively binds to ETB over ETA receptors (IC50s = 0.33 and 570 nM, respectively, for the porcine receptors). [Ala1,3,11,15]-Endothelin-1 (10 and 100 nM) increases wound closure percentage in a scratch assay using human umbilical vein endothelial cells (HUVECs). It increases body temperature in conscious rabbits when administered at doses of 0.15 or 0.3 nmol/kg. [Ala1,3,11,15]-Endothelin-1 (20 nmol/kg, i.v.) induces bronchoconstriction and increases mean arterial blood pressure in anesthetized guinea pigs. It has been used to determine the cross reactivity of monoclonal antibodies against endothelin in enzyme immunometric assays.Formal Name: L-alanyl-L-seryl-L-alanyl-L-seryl-L-seryl-L-leucyl-L-methionyl-L-alpha-aspartyl-L-lysyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan, trifluoroacetate salt. Synonyms: 4-Ala-ET-1, [Ala1,3,11,15]-ET-1. Molecular Formula: C109H163N25O32S . XCF3COOH. Formula Weight: 2367.7. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: ASASSLMDKEAVYFAHLDIIW-OH. Solubility: Water: Soluble. SMILES: [H]N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2)=O)=O)=O)CC(O)=O)=O)=O)CC3=CN=CN3)=O)C)=O)CC4=CC=CC=C4)=O)CC5=CC=C(O)C=C5)=O)=O)C)=O)=O)=O)CC(O)=O)=O)CCSC)=O)=O)=O)=O)C)=O)=O)C.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C109H163N25O32S.C2HF3O2/c1-16-56(9)87(107(163)128-79(109(165)166)43-64-47-113-68-28-22-21-27-67(64)68)134-108(164)88(57(10)17-2)133-102(158)78(46-85(143)144)126-98(154)73(40-54(5)6)122-100(156)76(44-65-48-112-52-114-65)121-90(146)59(12)116-96(152)74(41-62-25-19-18-20-26-62)124-99(155)75(42-63-30-32-66(138)33-31-63)127-106(162)86(55(7)8)132-92(148)61(14)115-93(149)70(34-35-83(139)140)119-94(150)69(29-23-24-37-110)118-101(157)77(45-84(141)142)125-95(151)71(36-38-167-15)120-97(153)72(39-53(3)4)123-104(160)82(51-137)131-105(161)81(50-136)130-91(147)60(13)117-103(159)80(49-135)129-89(145)58(11)111,3-2(4,5)1(6)7/h18-22,25-28,30-33,47-48,52-61,69-82,86-88,113,135-138H,16-17,23-24,29,34-46,49-51,110-111H2,1-15H3,(H,112,114)(H,115,149)(H,116,152)(H,117,159)(H,118,157)(H,119,150)(H,120,153)(H,121,146)(H,122,156)(H,123,160)(H,124,155)(H,125,151)(H,126,154)(H,127,162)(H,128,163)(H,129,145)(H,130,147)(H,131,161)(H,132,148)(H,133,158)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166),(H,6,7)/t56-,57-,58-,59-,60-,61-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,86-,87-,88-,/m0./s1. InChi Key: UUHAIRWHILIYER-RZCBFPPWSA-N.