Zu "K04198" wurden 64 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-EDNRB / Endothelin receptor type B
Artikelnummer: NSJ-FY12286
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. EDNRB antibody detects Endothelin receptor type B, encoded by the EDNRB gene on chromosome 13q22.3. EDNRB antibody is commonly used in vascular biology, developmental biology, and oncology. EDNRB is a G protein-coupled receptor (GPCR) for...
| Schlagworte: | Anti-EDNRB, Anti-Endothelin receptor type B, Anti-Endothelin receptor non-selective type, EDNRB Antibody / Endothelin... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Ro 46-2005
Artikelnummer: Cay43523-10
An ETA and ETB antagonist (IC50s = 220 and 160 nM, respectively), inhibits endothelin-1-induced secretion of arachidonic acid in primary rat mesangial cells (IC50 = 1.8 µM), prevents sarafotoxin S6-induced relaxation in preconstricted rat mesenteric arteries (pA2 = 6.47), increases cerebral blood flow in a rat model...
| Schlagworte: | 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-benzenesulfonamide |
| Anwendung: | Endothelin receptor type A/B antagonist |
| CAS | 150725-87-4 |
| MW: | 473.54 D |
ab 87,00 €
Sarafotoxin S6c (trifluoroacetate salt)
Artikelnummer: Cay30040-1
Solulibility: DMSO: Sparingly Soluble: 1-10 mg/ml: .
| Schlagworte: | SRTX-c, STX-S6c,... |
| Anwendung: | Peptide ETB receptor agonist, snake venom-derived toxin |
| MW: | 2515.76 D |
ab 123,00 €
Macitentan
Artikelnummer: Cay23304-50
Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively). Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells...
| Schlagworte: | ACT-064992, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-sulfamide |
| Anwendung: | Dual EDNRA / EDNRB antagonist |
| CAS | 441798-33-0 |
| MW: | 588.3 D |
ab 58,00 €
BQ-788 . sodium salt
Artikelnummer: AG-CP3-0012-M001
White to off-white solid. Soluble in DMSO, 0.1M sodium bicarbonate or 100% ethanol. Slightly soluble in methanol. Insoluble in water. Potent and selective endothelin B receptor (ETBR) antagonist.
| Schlagworte: | ETB Receptor Antagonist,... |
| Anwendung: | Endothelin B receptor (EDNRB, ETBR) antagonist |
| CAS | 156161-89-6 |
| MW: | 663,8 D |
ab 176,00 €
BQ-788 (sodium salt)
Artikelnummer: Cay17403-1
BQ-788 is a peptide endothelin type B (ETB) receptor antagonist (IC50 = 1.2 nM). It is selective for ETB over ETA receptors (IC50 = 280 nM), as well as angiotensin, calcitonin, or neuropeptide receptors at 10 µM. BQ-788 inhibits calcium mobilization induced by endothelin-1 (ET-1) in human Girrardi heart cells (IC50...
| Schlagworte: | N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine,... |
| Anwendung: | Potent, selective endothelin receptor type B antagonist |
| CAS | 156161-89-6 |
| MW: | 664.8 D |
ab 260,00 €
Bosentan-d4
Artikelnummer: Cay22097-5
Bosentan-d4 is an internal standard for the quantification of bosentan (Cay-11731) by GC- or LC-MS. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).Formal Name:...
| Schlagworte: | 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy-1,1,2,2-d4)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide |
| Anwendung: | GC-MS, LC-MS, internal standard |
| CAS | 1065472-77-6 |
| MW: | 555.6 D |
ab 409,00 €
Human ETRB / Endothelin B Receptor ELISA Kit
Artikelnummer: G-HUFI02433.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-EDNRB
Artikelnummer: NSJ-R32027
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Endothelin receptor type B, also known as ETB, is a protein that in humans is encoded by the EDNRB gene. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand,...
| Schlagworte: | Anti-ETRB, Anti-ET-B, Anti-ET-BR, Anti-EDNRB, Anti-Endothelin B receptor, Anti-Endothelin receptor non-selective type,... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Kendomycin
Artikelnummer: BVT-0001-C500
Antibiotic, Potent endothelin receptor antagonist, Anti-osteoporotic, Antibacterial, Cytotoxic, Mediates its cytotoxic effects, at least in part, through proteasome inhibition. Isolated from Streptomyces violaceoruber.
| Schlagworte: | (-)-TAN 2162 |
| Anwendung: | Endothelin receptor antagonist |
| CAS | 183202-73-5 |
| MW: | 486,6 D |
ab 95,00 €
Macitentan
Artikelnummer: LKT-M0009.1
Macitentan is a dual endothelin receptor (ET-A/B)antagonist that displays antihypertensive, anti-fibrotic, and anticancer activity, this compound exhibits slower receptor dissociation kinetics than other endothelin receptor antagonists. Macitentan is currently used to treat pulmonary arterial hypertension, as...
| Schlagworte: | ACT-064992, Actelion-1 |
| Anwendung: | Endothelin receptor type A antagonist, Endothelin receptor type B antagonist |
| CAS | 441798-33-0 |
| MW: | 588.27 D |
ab 73,00 €
Anti-Endothelin B Receptor
Artikelnummer: ARG58589.50
Protein function: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. [The UniProt Consortium]
| Schlagworte: | Anti-ETRB, Anti-ET-B, Anti-ET-BR, Anti-Endothelin receptor type B, Anti-Endothelin receptor non-selective type |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
551,00 €