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Zu "K04198" wurden 37 Artikel gefunden!
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Artikelnummer: Cay39017-1
[Ala1,3,11,15]-Endothelin-1 is an endothelin receptor type B (ETB) agonist and linear synthetic peptide derivative of endothelin-1 in which all four cysteine residues have been substituted with alanine. It selectively binds to ETB over ETA receptors (IC50s = 0.33 and 570 nM, respectively, for the porcine receptors)....
Schlagworte: | [Ala1,3,11,15]-ET-1, 4-Ala-ET-1,... |
Anwendung: | ETB receptor agonist |
MW: | 2367.7 D |
ab 53,00 €
Artikelnummer: ELK-ELK2771.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ETRB. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ETRB. Next,...
Schlagworte: | ETRB, ET-B, ET-BR, Endothelin receptor type B, Endothelin receptor non-selective type |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-EA282.100
N/A Protein function: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. [The UniProt Consortium] Recommended dilutions: IHC 1:100-200. Cellular localization: Cell membrane
Schlagworte: | Anti-ET-B, Anti-ETRB, Anti-ET-BR, Anti-Endothelin receptor type B, Anti-Endothelin receptor non-selective type, Endothelin... |
Anwendung: | IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
283,00 €
Artikelnummer: Cay23304-50
Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively). Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells...
Schlagworte: | ACT-064992, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-sulfamide |
Anwendung: | Dual EDNRA / EDNRB antagonist |
CAS | 441798-33-0 |
MW: | 588.3 D |
ab 53,00 €
Artikelnummer: AG-CP3-0012-M001
White to off-white solid. Soluble in DMSO, 0.1M sodium bicarbonate or 100% ethanol. Slightly soluble in methanol. Insoluble in water. Potent and selective endothelin B receptor (ETBR) antagonist.
Schlagworte: | ETB Receptor Antagonist,... |
Anwendung: | Endothelin B receptor (EDNRB, ETBR) antagonist |
CAS | 156161-89-6 |
MW: | 663,8 D |
ab 176,00 €
Artikelnummer: Cay17403-1
BQ-788 is a peptide endothelin type B (ETB) receptor antagonist (IC50 = 1.2 nM). It is selective for ETB over ETA receptors (IC50 = 280 nM), as well as angiotensin, calcitonin, or neuropeptide receptors at 10 µM. BQ-788 inhibits calcium mobilization induced by endothelin-1 (ET-1) in human Girrardi heart cells (IC50...
Schlagworte: | N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine,... |
Anwendung: | Potent, selective endothelin receptor type B antagonist |
CAS | 156161-89-6 |
MW: | 664.8 D |
ab 234,00 €
Artikelnummer: Cay22097-5
Bosentan-d4 is an internal standard for the quantification of bosentan (Cay-11731) by GC- or LC-MS. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).Formal Name:...
Schlagworte: | 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy-1,1,2,2-d4)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide |
Anwendung: | GC-MS, LC-MS, Internal standard |
CAS | 1065472-77-6 |
MW: | 555.6 D |
ab 369,00 €
Artikelnummer: G-HUFI02433.96
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
641,00 €
Artikelnummer: NSJ-R32027
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Endothelin receptor type B, also known as ETB, is a protein that in humans is encoded by the EDNRB gene. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand,...
Schlagworte: | Anti-ETRB, Anti-ET-B, Anti-ET-BR, Anti-EDNRB, Anti-Endothelin B receptor, Anti-Endothelin receptor non-selective type,... |
Anwendung: | WB, IHC (paraffin) |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Artikelnummer: BVT-0001-C500
Antibiotic, Potent endothelin receptor antagonist, Anti-osteoporotic, Antibacterial, Cytotoxic, Mediates its cytotoxic effects, at least in part, through proteasome inhibition. Isolated from Streptomyces violaceoruber.
Schlagworte: | (-)-TAN 2162 |
Anwendung: | Endothelin receptor antagonist |
CAS | 183202-73-5 |
MW: | 486,6 D |
ab 75,00 €
Artikelnummer: LKT-M0009.1
Macitentan is a dual endothelin receptor (ET-A/B)antagonist that displays antihypertensive, anti-fibrotic, and anticancer activity, this compound exhibits slower receptor dissociation kinetics than other endothelin receptor antagonists. Macitentan is currently used to treat pulmonary arterial hypertension, as...
Schlagworte: | ACT-064992, Actelion-1 |
Anwendung: | Endothelin receptor type A antagonist, Endothelin receptor type B antagonist |
CAS | 441798-33-0 |
MW: | 588.27 D |
ab 69,00 €
Artikelnummer: ARG58589.50
Protein function: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. [The UniProt Consortium]
Schlagworte: | Anti-ETRB, Anti-ET-B, Anti-ET-BR, Anti-Endothelin receptor type B, Anti-Endothelin receptor non-selective type |
Anwendung: | IHC (paraffin), WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
520,00 €