Anti-phospho-CaMKII (Thr286)

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity Pak JH, et al. Proc Natl Acad Sci U S A. 2000 Oct 10, 97(21): 11232-11237 Hudmon A, et al. J Cell Biol. Author manuscript, available in PMC 2006 May 7 Miller P, et al. PLoS Biol. 2005 Apr, 3(4): e107 Runyan JD, et al. Learn Mem. 2005 Mar, 12(2): 103-110. Protein function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). [The UniProt Consortium]