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KN-93
KN-93

Artikelnummer: Cay13319-1

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). More...
Schlagworte: N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide
Anwendung: CaMKII inhibitor
CAS 139298-40-1
MW: 501 D
ab 108,00 €
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KN-92 (hydrochloride)
KN-92 (hydrochloride)

Artikelnummer: Cay9000890-1

KN-92 is an inactive derivative of KN-93, the selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII). At concentrations up to 25 µM, KN-92 is ineffective at inhibiting CaMKII or arresting cell growth of NIH 3T3 fibroblasts. It is intended to be used as a control compound in studies designed to...
Schlagworte: 2-[N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine, monohydrochloride
Anwendung: CaMKII inhibitor
CAS 1431698-47-3
MW: 493.4 D
ab 108,00 €
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KN-93 (water soluble)
KN-93 (water soluble)

Artikelnummer: AG-CR1-0065-M001

Selective Ca2 dependent protein kinase II inhibitor, Insulin release inhibitor, Acid secretion inhibitor, G1 cell cycle arrest inducer, Apoptosis inducer, Ion channel inhibitor, ROS inducer, Androgen receptor inhibitor.
Schlagworte: KN-93 . H3PO4, 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine . H3PO4
Anwendung: Ca2 dependent protein kinase II inhibitor
MW: 501 D
ab 50,00 €
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KN-62
KN-62

Artikelnummer: Cay13318-5

KN-62 is a selective, cell permeable inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII, IC50 = 900 nM). It does not affect the activity of several other kinases when tested at 10 µM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM).
Schlagworte: 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester,...
Anwendung: CAMKII inhibitor
CAS 127191-97-3
MW: 721.9 D
ab 49,00 €
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KN-93 (phosphate)
KN-93 (phosphate)

Artikelnummer: Cay21472-1

KN-93 (phosphate) is a potent and selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII) (Ki = 370 nM), inhibiting both the alpha- and beta-subunits of CaMKII. It does not have significant effects on cAMP-dependent protein kinase, Ca2+/phospholipid-dependent protein kinase, myosin light chain kinase, or...
Schlagworte: N-[2-[[[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide,...
Anwendung: CaMKII inhibitor
CAS 1188890-41-6
MW: 599 D
ab 32,00 €
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Anti-phospho-CaM Kinase II (Thr286)
Anti-phospho-CaM Kinase II (Thr286)

Artikelnummer: 612-401-C71

Anti-CaM Kinase II pT286 Antibody is directed against CaM Kinase II protein phosphorylated at T286. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific...
Schlagworte: Anti-phospho-Camk2a, EC=2.7.11.17, Anti-phospho-CaMK-II subunit alpha, Anti-phospho-CaM kinase II subunit alpha,...
Anwendung: ELISA, WB
Reaktivität: Rat
501,00 €
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Anti-phospho-CaMKII (Thr286)
Anti-phospho-CaMKII (Thr286)

Artikelnummer: ARG52238.50

Protein function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates...
Schlagworte: Anti-phospho-Camk2a, Anti-phospho-CaMK-II subunit alpha, Anti-phospho-CaM kinase II subunit alpha,...
Anwendung: WB
Reaktivität: Rat
498,00 €
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Calmodulin-Dependent Protein Kinase II (290-309)
Calmodulin-Dependent Protein Kinase II (290-309)

Artikelnummer: Cay24318-500

Calmodulin-dependent protein kinase II (290-309) is a synthetic peptide derived from the rat brain protein sequence that contains the calmodulin binding domain. It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with an IC50 value of 52 nM and CaMKII-dependent phosphodiesterase activity (IC50 = 1.1...
Schlagworte: L-leucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-asparaginyl-L-alanyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-lysylglycyl-L-alanyl...
Anwendung: CaMKII inhibitor, Calmodulin binding domain
CAS 115044-69-4
MW: 2273.8 D
118,00 €
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Human CAMK2A / CaMKII alpha protein CaM Kinase II alpha ELISA Kit
Human CAMK2A / CaMKII alpha protein CaM Kinase II alpha...

Artikelnummer: G-HUFI02287.96

Anwendung: ELISA
Reaktivität: Human
629,00 €
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Anti-CaMKII, clone 6G9
Anti-CaMKII, clone 6G9

Artikelnummer: 200-301-F00

Anti-CaMKII Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with CaMKII from mouse, rat, and bovine based on 100% homology with the immunizing sequence. Cross-reactivity with CaMKII from other sources has not been determined. Cell Signaling research. Protein...
Schlagworte: Anti-Camk2a, EC=2.7.11.17, Anti-CaMK-II subunit alpha, Anti-CaM kinase II subunit alpha, Anti-Calcium/calmodulin-dependent...
Anwendung: ELISA, IHC, IF, IP, WB
Reaktivität: Mouse, Rat, Bovine
506,00 €
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Anti-CaMKII, clone 22B1
Anti-CaMKII, clone 22B1

Artikelnummer: 200-301-F01

Anti-CaMKII Antibody was purified by Protein G chromatography. This monoclonal antibody is specific for CaMKII protein. A BLAST analysis was used to suggest cross-reactivity with CaMKII from rat based on 100% homology with the immunizing sequence. Cross-reactivity with CaMKII from other sources has not been...
Schlagworte: Anti-Camk2a, EC=2.7.11.17, Anti-CaMK-II subunit alpha, Anti-CaM kinase II subunit alpha, Anti-Calcium/calmodulin-dependent...
Anwendung: ELISA, IF, IP, WB
Reaktivität: Rat
506,00 €
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Anti-CaMKII (CaM Kinase II)
Anti-CaMKII (CaM Kinase II)

Artikelnummer: 600-401-873

Protein function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. [The...
Schlagworte: Anti-Camk2a, EC=2.7.11.17, Anti-CaMK-II subunit alpha, Anti-CaM kinase II subunit alpha, Anti-Calcium/calmodulin-dependent...
Anwendung: ELISA, WB
Reaktivität: Human
506,00 €
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