PTM-spezifische Antikörper

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Anti-phospho-AKT (Ser473), clone 17F6.B11
Anti-phospho-AKT (Ser473), clone 17F6.B11

Artikelnummer: 200-301-268S

Protein function: AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range...
Schlagworte: Anti-phospho-PKB, Anti-phospho-AKT1, Anti-phospho-PKB alpha, EC=2.7.11.1, Anti-phospho-RAC-PK-alpha, Anti-phospho-Protein...
Anwendung: ELISA, WB, IHC
Reaktivität: Human, Mouse
ab 132,00 €
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Anti-phospho-ATM Protein Kinase (Ser1981), clone 10H11.E12
Anti-phospho-ATM Protein Kinase (Ser1981), clone 10H11.E12

Artikelnummer: 200-301-400S

Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of...
Schlagworte: Anti-phospho-ATM, Anti-phospho-A-T mutated, EC=2.7.11.1, Anti-phospho-Serine-protein kinase ATM, Anti-phospho-Ataxia...
Anwendung: ELISA, WB, IP, IF
Reaktivität: Human, Mouse, Rat
ab 132,00 €
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Anti-phospho-ATM Protein Kinase (Ser1981), clone 7C10D8
Anti-phospho-ATM Protein Kinase (Ser1981), clone 7C10D8

Artikelnummer: 200-301-500

Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of...
Schlagworte: Anti-phospho-ATM, Anti-phospho-A-T mutated, EC=2.7.11.1, Anti-phospho-Serine-protein kinase ATM, Anti-phospho-Ataxia...
Anwendung: ELISA, WB, IHC, FC
Reaktivität: Human, Mouse
577,00 €
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Anti-phospho-Histone H2AvD (Ser137)
Anti-phospho-Histone H2AvD (Ser137)

Artikelnummer: 600-401-914

Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA...
Schlagworte: Anti-phospho-H2AvD, Anti-phospho-H2A.Z, Anti-phospho-His2Av, Anti-phospho-CG5499, Anti-phospho-H2A.F/Z,...
Anwendung: ELISA, WB, IHC
Reaktivität: Drosophila
493,00 €
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Anti-phospho-ATG13 (Ser318)
Anti-phospho-ATG13 (Ser318)

Artikelnummer: 600-401-C49

Protein function: Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. [The UniProt Consortium]
Schlagworte: Anti-phospho-ATG13, Anti-phospho-KIAA0652, Anti-phospho-Autophagy-related protein 13
Anwendung: ELISA, WB, FC
Reaktivität: Human
493,00 €
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Anti-phospho-VASP (Ser239), clone 16C2
Anti-phospho-VASP (Ser239), clone 16C2

Artikelnummer: 0047-100

Does not cross-react with the non-phosphorylated form of VASP nor with unrelated serine-phosphorylated proteins.
Schlagworte: (pS239) Anti-phospho-VASP, Anti-phospho-VASP, Anti-phospho-Vasodilator-stimulated phosphoprotein
Anwendung: WB, ELISA, IP, ICC, FC
Reaktivität: Human, Mouse
390,00 €
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Anti-phospho-VASP (Ser157), clone 5C6
Anti-phospho-VASP (Ser157), clone 5C6

Artikelnummer: 0085-100

Does not cross-react with the non-phosphorylated form of protein.
Schlagworte: (pS157) Anti-phospho-VASP, Anti-phospho-VASP, Anti-phospho-Vasodilator-stimulated phosphoprotein
Anwendung: WB, ELISA, IP, ICC, FC
Reaktivität: Human, Mouse
390,00 €
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Anti-Polyglutamylation Modification, clone GT335
Anti-Polyglutamylation Modification, clone GT335

Artikelnummer: AG-20B-0020-C100

Recognizes the posttranslational modification (poly)glutamylation on proteins. Reacts with polyglutamylated alpha- and beta-tubulin. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Polyglutamylation is a post-translational modification in which glutamate side chains of variable lengths are formed on...
Schlagworte: Polyglutamylated Tubulin, Glutamylated Tubulin, Postranslational Protein Glutamylation
Anwendung: ICC, IP, WB
Reaktivität: All
418,00 €
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Anti-Polyglutamate chain [Poly-E]
Anti-Polyglutamate chain [Poly-E]

Artikelnummer: AG-25B-0030-C050

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. Microtubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule diversity: the expression of different alpha- and...
Schlagworte: Anti-Poly-E, pAb (IN105), Anti-Poly-Glu
Anwendung: WB, ICC
Reaktivität: Broad
385,00 €
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Anti-phospho-EZH2 (Ser21) (IHC)
Anti-phospho-EZH2 (Ser21) (IHC)

Artikelnummer: IHC-00388

Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys- 27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1,...
Schlagworte: Anti-phospho-EZH2, Anti-phospho-KMT6, Anti-phospho-ENX-1, EC=2.1.1.43, Anti-phospho-Enhancer of zeste homolog 2,...
Anwendung: IHC
Reaktivität: Human, Mouse
ab 125,00 €
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Anti-gamma-H2AX
Anti-gamma-H2AX

Artikelnummer: A300-081A

Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA...
Schlagworte: Anti-H2AX, Anti-H2AFX, Anti-H2a/x, Anti-Histone H2AX, Anti-Histone H2A.X
Anwendung: WB, IHC, ICC/IF
Reaktivität: Human, Mouse
ab 125,00 €
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Anti-phospho-RPA32 (Ser4/Ser8)
Anti-phospho-RPA32 (Ser4/Ser8)

Artikelnummer: A300-245A-T

Protein function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA...
Schlagworte: Anti-phospho-RPA2, Anti-phospho-REPA2, Anti-phospho-RP-A p34, Anti-phospho-RP-A p32, Anti-phospho-RF-A protein 2,...
Anwendung: WB, IP, IHC, ICC/IF
Reaktivität: Human, Mouse
ab 125,00 €
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