Anti-TrkB (Tyrosine Kinase Receptor B) (BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kin

TrkB is a member of the neurotrophic tyrosine receptor kinase family. It is a membrane-bound receptor and upon neurotrophin binding, it phosphorylates itself as well as MAPK pathways members. TrkB is the receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). It is Involved in the development and/or maintenance of the nervous system. Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications have not been tested. , Recommended Dilutions: , ELISA: 1:10,000, Immunohistochemistry: 1:1,000-1:3,000 dilution used to stain frozen sections of rat peripheral sensory ganglia, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.