Zu "K04360" wurden 110 Artikel gefunden!
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Rat NTRK2 (Neurotrophic Tyrosine Kinase Receptor Type 2)...
Artikelnummer: ELK-ELK7583.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat NTRK2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat NTRK2. Next,...
| Schlagworte: | Trkb, Trk-B, Ntrk2, TrkB tyrosine kinase, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 365,00 €
Human NTRK2 (Neurotrophic Tyrosine Kinase Receptor Type...
Artikelnummer: ELK-ELK5214.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human NTRK2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NTRK2. Next,...
| Schlagworte: | TRKB, Trk-B, NTRK2, GP145-TrkB, TrkB tyrosine kinase, Tropomyosin-related kinase B, BDNF/NT-3 growth factors receptor,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
TRKB Kinase Assay Kit
Artikelnummer: BPS-78591
The TRKB Kinase Assay Kit is designed to measure TRKB kinase activity for screening and profiling applications using ADP-Glo(R) as a detection reagent.
| Schlagworte: | TRKB, Trk-B, NTRK2, GP145-TrkB, TrkB tyrosine kinase, Tropomyosin-related kinase B, BDNF/NT-3 growth factors receptor,... |
| Anwendung: | Enzyme kinetics, small molecular inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
789,00 €
ANA-12
Artikelnummer: Cay14309-5
ANA-12 is a TrkB receptor antagonist that prevents activation of the receptor by BDNF with IC50 values of 45.6 nM and 41.1 µM for the high and low affinity sites of the receptor, respectively. It does not affect TrkA or TrkC in an assay of neurite outgrowth. Mice administered ANA-12 demonstrated reduced anxiety- and...
| Schlagworte: | N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide |
| Anwendung: | TrkB antagonist |
| CAS | 219766-25-3 |
| MW: | 407.5 D |
ab 44,00 €
Entrectinib
Artikelnummer: Cay19476-1
Entrectinib is an inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as C-ros oncogene 1 (ROS1, IC50 = 0.2 nM) and anaplastic lymphoma kinase (ALK, IC50 = 1.6 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance...
| Schlagworte: | NMS-E628, RXDX-101,... |
| Anwendung: | TrkA/B/C inhibitor |
| CAS | 1108743-60-7 |
| MW: | 560.6 D |
ab 48,00 €
7,8-Dihydroxyflavone
Artikelnummer: Cay16946-100
7,8-Dihydroxyflavone (7,8-DHF) is a flavone that has been found in G. aesculifolia and has diverse biological activities. It binds to tropomyosin-related kinase B (TrkB, Kd = 320 nM) and induces TrkB autophosphorylation in primary mouse hippocampal neurons. In vivo, 7,8-DHF (5 mg/kg) reduces neuronal apoptosis and...
| Schlagworte: | 7,8-DHF, 7,8-dihydroxy-2-phenyl-4H-1-benzopyran-4-one |
| Anwendung: | TrkB agonist |
| CAS | 38183-03-8 |
| MW: | 254.2 D |
ab 43,00 €
LOXO-101
Artikelnummer: Cay27056-1
LOXO-101 is an inhibitor of the tropomyosin-related kinases TrkA, TrkB, and TrkC (IC50s = 2-20 nM). It is selective for TrkA, -B, and -C over a panel of 226 kinases at 1 µM. LOXO-101 inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = In vivo, LOXO-101 (60 and 200 mg/kg)...
| Schlagworte: | ARRY-470, Larotrectinib,... |
| Anwendung: | TrkA / TrkB / TrkC inhibitor |
| CAS | 1223403-58-4 |
| MW: | 428.4 D |
ab 60,00 €
LM22A-4
Artikelnummer: Cay22082-5
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB, IC50 = 47 nM in a fluorescence anisotropy assay). It selectively inhibits BDNF binding to 3T3 cells expressing TrkB over those expressing TrkA, TrkC, or p75NTR. In vitro, LM22A-4 increases...
| Schlagworte: | N1,N3,N5-tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide |
| Anwendung: | TrkB agonist |
| CAS | 37988-18-4 |
| MW: | 339.3 D |
ab 84,00 €
Anti-phospho-TrkB (Tyr515)
Artikelnummer: ARG51799.100
Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and...
| Schlagworte: | Anti-phospho-TRKB, Anti-phospho-NTRK2, Anti-phospho-Trk-B, Anti-phospho-GP145-TrkB, EC=2.7.10.1, Anti-phospho-TrkB... |
| Anwendung: | ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 436,00 €
Anti-phospho-TrkB (Tyr705)
Artikelnummer: ARG51800.100
Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and...
| Schlagworte: | Anti-phospho-TRKB, Anti-phospho-NTRK2, Anti-phospho-Trk-B, Anti-phospho-GP145-TrkB, EC=2.7.10.1, Anti-phospho-TrkB... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 436,00 €
Anti-TrkB
Artikelnummer: ARG65656.100
Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and...
| Schlagworte: | Anti-TRKB, Anti-NTRK2, Anti-Trk-B, Anti-GP145-TrkB, EC=2.7.10.1, Anti-TrkB tyrosine kinase, Anti-Tropomyosin-related... |
| Anwendung: | WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
784,00 €
TRKB, active human recombinant protein, GST-tag
Artikelnummer: BPS-40281
Human TRKB, also known as NTKR2 (Neurotrophic Tyrosine Kinase Receptor, type 2) or BDNF/NT-3 Receptor, GenBank Accession No. NM_001018064, amino acids 456-822(end), with N-terminal GST-tag, MW=67.5 kDa, expressed in Sf9 cells via a baculovirus expression system.
| Schlagworte: | TRKB, Trk-B, NTRK2, GP145-TrkB, TrkB tyrosine kinase, Tropomyosin-related kinase B, BDNF/NT-3 growth factors receptor,... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Baculovirus |
| Ursprungsart: | human |
| MW: | 67.5 kD |
525,00 €