Zu "K04360" wurden 151 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-Recombinant Pan Trk, clone A687
Artikelnummer: E-AN301971L.100
The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. Neurotrophin signaling through these receptors regulates a number of...
| Schlagworte: | Anti-NTRK2, Anti-GP145-TrkB, Anti-TrkB tyrosine kinase, Anti-Tropomyosin-related kinase B, Anti-BDNF/NT-3 growth factors... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | rat, mouse |
ab 304,00 €
Mouse TrkB ELISA Kit
Artikelnummer: ARG81761.96
Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and...
| Schlagworte: | Trk-B, GP145-TrkB/GP95-TrkB, TrkB tyrosine kinase, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
1.118,00 €
Human TrkB ELISA Kit
Artikelnummer: ARG81760.96
Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and...
| Schlagworte: | TRKB, Trk-B, NTRK2, GP145-TrkB, TrkB tyrosine kinase, Tropomyosin-related kinase B, BDNF/NT-3 growth factors receptor,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.118,00 €
TrkB/NTRK2, His, Human
Artikelnummer: GSC-Z05927-100
Neuron differentiation is likely regulated by a combination of transcription and growth factors. Embryonically, most geniculate neuron development is regulated by the growth factor brain derived neurotrophic factor (BDNF). BDNF expression becomes restricted to subpopulations of taste receptor cells with specific...
| Schlagworte: | NTRK2, GP145-TrkB, TrkB tyrosine kinase, Tropomyosin-related kinase B, BDNF/NT-3 growth factors receptor, Neurotrophic... |
| Ursprungsart: | human |
| MW: | 45.2 kD |
ab 376,00 €
Cyclotraxin B
Artikelnummer: Cay42991-1
Cyclotraxin B is a cyclic peptide and negative allosteric modulator of tropomysin-related kinase B (TrkB). It inhibits BDNF-induced TrkB activity in a kinase receptor activation ELISA (KIRA-ELISA) using tetracycline-responsive CHO-K1 cells expressing recombinant human TrkB (TetOn-rhTrkB cells, IC50 = 0. nM). It also...
| Schlagworte: | cyclic (1->11)-disulfide... |
| Anwendung: | Cyclic peptide, negative allosteric TrkB modulator |
| CAS | 1203586-72-4 |
| MW: | 1200.37 D |
ab 266,00 €
ANA-12
Artikelnummer: Cay14309-5
ANA-12 is a TrkB receptor antagonist that prevents activation of the receptor by BDNF with IC50 values of 45.6 nM and 41.1 µM for the high and low affinity sites of the receptor, respectively. It does not affect TrkA or TrkC in an assay of neurite outgrowth. Mice administered ANA-12 demonstrated reduced anxiety- and...
| Schlagworte: | N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide |
| Anwendung: | TrkB antagonist |
| CAS | 219766-25-3 |
| MW: | 407.5 D |
ab 50,00 €
Entrectinib
Artikelnummer: Cay19476-1
Entrectinib is an inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as C-ros oncogene 1 (ROS1, IC50 = 0.2 nM) and anaplastic lymphoma kinase (ALK, IC50 = 1.6 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance...
| Schlagworte: | NMS-E628, RXDX-101,... |
| Anwendung: | TrkA/B/C inhibitor |
| CAS | 1108743-60-7 |
| MW: | 560.6 D |
ab 54,00 €
7,8-Dihydroxyflavone
Artikelnummer: Cay16946-100
7,8-Dihydroxyflavone (7,8-DHF) is a flavone that has been found in G. aesculifolia and has diverse biological activities. It binds to tropomyosin-related kinase B (TrkB, Kd = 320 nM) and induces TrkB autophosphorylation in primary mouse hippocampal neurons. In vivo, 7,8-DHF (5 mg/kg) reduces neuronal apoptosis and...
| Schlagworte: | 7,8-DHF, 7,8-dihydroxy-2-phenyl-4H-1-benzopyran-4-one |
| Anwendung: | TrkB agonist |
| CAS | 38183-03-8 |
| MW: | 254.2 D |
ab 49,00 €
LOXO-101
Artikelnummer: Cay27056-1
LOXO-101 is an inhibitor of the tropomyosin-related kinases TrkA, TrkB, and TrkC (IC50s = 2-20 nM). It is selective for TrkA, -B, and -C over a panel of 226 kinases at 1 µM. LOXO-101 inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = In vivo, LOXO-101 (60 and 200 mg/kg)...
| Schlagworte: | ARRY-470, Larotrectinib,... |
| Anwendung: | TrkA / TrkB / TrkC inhibitor |
| CAS | 1223403-58-4 |
| MW: | 428.4 D |
ab 67,00 €
LM22A-4
Artikelnummer: Cay22082-5
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB, IC50 = 47 nM in a fluorescence anisotropy assay). It selectively inhibits BDNF binding to 3T3 cells expressing TrkB over those expressing TrkA, TrkC, or p75NTR. In vitro, LM22A-4 increases...
| Schlagworte: | N1,N3,N5-tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide |
| Anwendung: | TrkB agonist |
| CAS | 37988-18-4 |
| MW: | 339.3 D |
ab 93,00 €
Anti-phospho-TrkB (Tyr515)
Artikelnummer: ARG51799.100
Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and...
| Schlagworte: | Anti-phospho-TRKB, Anti-phospho-NTRK2, Anti-phospho-Trk-B, Anti-phospho-GP145-TrkB, EC=2.7.10.1, Anti-phospho-TrkB... |
| Anwendung: | ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 471,00 €
Anti-phospho-TrkB (Tyr705)
Artikelnummer: ARG51800.100
Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and...
| Schlagworte: | Anti-phospho-TRKB, Anti-phospho-NTRK2, Anti-phospho-Trk-B, Anti-phospho-GP145-TrkB, EC=2.7.10.1, Anti-phospho-TrkB... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 471,00 €