Anti-RORgamma

RORgamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. The specific functions of this protein are not known. However, reports suggest that this protein is a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. RORgamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR-gamma shares 50 to 51% sequence identity with RORalpha and RORbeta and is 88% identical to mouse RORgamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.Synonyms: NR1F3, RAR-Related Orphan Receptor C, Retinoid-Related Orphan Receptor gamma. Immunogen: A peptide within the region of amino acids 1-50 of human RORgamma. Formulation: (Request formulation change), 100 µg peptide affinity-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Host: Rabbit. Isotype: rabbit Ig. Applications: IHC and WB. Origin: Animal/Rabbit.