Zu "K08534" wurden 82 Artikel gefunden!
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RORgamma (human) Reporter Assay Kit
Artikelnummer: IB-IB04001
This human RAR-related orphan receptor gamma (RORgamma) mRNA is expressed from the RORC gene in two forms via alternate usage of tissue-specific promoters. Variant 1 mRNA is expressed in numerous tissues, and encodes receptor isoform 1, referred to as RORgamma. Variant 2 mRNA comprises an alternate exon 1 that...
| Schlagworte: | RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, RAR-related orphan receptor C, Retinoid-related... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.507,00 €
NEU
XY-018
Artikelnummer: Cay43111-10
XY-018 is an inverse agonist of retinoic acid receptor-related orphan receptor gamma (RORgamma). It induces RORgamma transcriptional activity in a reporter assay using LNCaP cells (IC50 = 0. µM). XY-018 selectively induces RORgamma transcriptional activity over RORalpha transcriptional activity in HEK293T cells...
| Schlagworte: | N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-2-nitro-benzeneacetamide |
| Anwendung: | ROR gamma inverse agonist |
| CAS | 1873358-87-2 |
| MW: | 516.37 D |
ab 151,00 €
Anti-RoRgT
Artikelnummer: ABS-KC-3300.100
Protein function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and...
| Schlagworte: | RoRgT Antibody |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
GSK2981278
Artikelnummer: Cay20974-25
GSK2981278 is an inverse agonist of retinoic acid receptor-related nuclear receptor gamma (RORgamma, IC50 = 17 nM in a transactivation assay). It is selective for RORgamma over RORalpha. GSK2981278 inhibits IL-17A and IL-22 protein secretion from isolated human peripheral blood T cells grown under Th17 skewing...
| Schlagworte: | N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-benzenesulfonamide |
| Anwendung: | Potent, selective ROR gamma inverse agonist |
| CAS | 1474110-21-8 |
| MW: | 461.6 D |
ab 52,00 €
RORgammat inhibitor 2
Artikelnummer: TGM-T72595-100mg
Description: RORgammat Inhibitor 2, a potent inhibitor of RORgammat, exhibits an IC50 of 9.2 nM and is utilized in the study of cancer, inflammation, or autoimmune diseases that are mediated by RORgammat. Target: Others. Smiles:...
| Anwendung: | ROR-gamma-t inhibitor |
| CAS | 2673278-10-7 |
| MW: | 672.66 D |
ab 2.272,00 €
Cedirogant
Artikelnummer: TGM-T9635-100mg
Description: Cedirogant (ABBV-157) is an orally active, retinoid-related orphan receptor-gammat (RORgammat) inverse agonist used in psoriasis studies. Target: ROR. Smiles: OC(=O)CC1CCN(CC1)C(=O)c1ccc(Cl)c(Cn2ccc3cc(cc(Cl)c23)C(F)(F)F)c1Cl. References: Elena Campione, et al. Experimental Pharmacological Management of...
| Schlagworte: | ABBV-157 |
| Anwendung: | Targets RAR-related orphan receptor gamma (NR1F3, RORC) |
| CAS | 2055496-11-0 |
| MW: | 547.78 D |
ab 88,00 €
RORC Protein, Human, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-01792-100ug
Description: RORC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.2 kDa and the accession number is P51449.
| Schlagworte: | RAR-related orphan receptor C, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor ROR-gamma, RORC, Nuclear... |
| MW: | 74.2 kD |
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Cintirorgon
Artikelnummer: TGM-TQ0007-100mg
Description: Cintirorgon (LYC-55716) is a selective, oral agonist of RORgamma, modulating gene expression in RORgamma-expressing T lymphocyte immune cells. Target: ROR. Smiles: CC(C)(C[C@H]1CN(c2cc(ccc2O1)-c1cc(F)cc(OC(F)F)c1)S(=O)(=O)c1cccc(c1)C(F)(F)F)C(O)=O. References: Lycera Announces Initiation of Phase 1/2a...
| Schlagworte: | LYC-55716 |
| Anwendung: | RORgamma agonist |
| CAS | 2055536-64-4 |
| MW: | 603.53 D |
ab 77,00 €
SR2211
Artikelnummer: TGM-T16929-100mg
Description: SR2211 is a specific modulator and an inverse agonist of RORgamma(IC50 = 320 nM, Ki = 105 nM). Target: ROR. Smiles: OC(c1ccc(c(F)c1)-c1ccc(CN2CCN(Cc3ccncc3)CC2)cc1)(C(F)(F)F)C(F)(F)F. References: Kumar N, et al. Identification of SR2211: a potent synthetic RORgamma-selective modulator. ACS Chem Biol....
| Anwendung: | ROR gamma agonist |
| CAS | 1359164-11-6 |
| MW: | 527.48 D |
ab 45,00 €
Zymostenol
Artikelnummer: TGM-T35321-10mg
Description: Zymostenol (5a-Cholest-8-en-3b-ol) is a RORgamma agonist with an EC50 of 1 µM and serves as a late-stage precursor in cholesterol biosynthesis. Target: Endogenous Metabolite, ROR. Smiles: C[C@@]12[C@](C3=C([C@]4(C)[C@@](CC3)(C[C@@H](O)CC4)[H])CC1)(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]. References: Hu X,...
| Schlagworte: | Delta8-Cholesterol, 5a-Cholest-8-en-3b-ol, delta(8)-Cholestenol |
| Anwendung: | Late-stage cholesterol biosynthesis precursor, RORgamma agonist |
| CAS | 566-97-2 |
| MW: | 386.65 D |
ab 261,00 €
7beta,27-dihydroxy Cholesterol
Artikelnummer: TGM-T36998-1mg
Description: 7beta,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor gamma (RORgamma) and RORgammat. [1] It activates RORgamma- or RORgammat-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing...
| Schlagworte: | 7beta,27-DHC, 7beta,27-dihydroxy Cholesterol |
| Anwendung: | Oxysterol, RORgamma/RORgammat agonist |
| CAS | 240129-43-5 |
| MW: | 418.65 D |
ab 295,00 €
ML 209
Artikelnummer: TGM-T37587-100mg
Description: ML-209 is an antagonist of retinoic acid receptor-related orphan receptor gammat (RORgammat, IC50= 1.1 µM in a reporter assay).1It inhibits RORgammat-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORgammat-dependent differentiation of isolated na?ve...
| Anwendung: | RORgammat antagonist |
| CAS | 1334526-14-5 |
| MW: | 441.52 D |
ab 93,00 €