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RORgamma (human) Reporter Assay Kit
RORgamma (human) Reporter Assay Kit

Artikelnummer: IB-IB04001

This human RAR-related orphan receptor gamma (RORgamma) mRNA is expressed from the RORC gene in two forms via alternate usage of tissue-specific promoters. Variant 1 mRNA is expressed in numerous tissues, and encodes receptor isoform 1, referred to as RORgamma. Variant 2 mRNA comprises an alternate exon 1 that...
Schlagworte: RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, RAR-related orphan receptor C, Retinoid-related...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
ab 1.448,00 €
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Anti-RORC / ROR gamma
Anti-RORC / ROR gamma

Artikelnummer: NSJ-RQ7200

0.5mg/ml if reconstituted with 0.2ml sterile DI water. RAR-related orphan receptor gamma (RORg) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone...
Schlagworte: Anti-RORC, Anti-NR1F3, Anti-Nuclear receptor ROR-gamma, Anti-Nuclear receptor RZR-gamma, Anti-RAR-related orphan receptor...
Anwendung: WB, FC, Direct ELISA
Wirt: Rabbit
Spezies-Reaktivität: human
755,00 €
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-10 %
Rabattaktion
Human RORg (RAR Related Orphan Receptor Gamma) ELISA Kit
Human RORg (RAR Related Orphan Receptor Gamma) ELISA Kit

Artikelnummer: ELK-ELK4344.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RORg. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RORg. Next,...
Schlagworte: RORC, NR1F3, Nuclear receptor RZR-gamma, Nuclear receptor ROR-gamma, RAR-related orphan receptor C, Retinoid-related...
Anwendung: ELISA
Spezies-Reaktivität: human
365,00 € ab 328,50 €
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GSK2981278
GSK2981278

Artikelnummer: Cay20974-25

GSK2981278 is an inverse agonist of retinoic acid receptor-related nuclear receptor gamma (RORgamma, IC50 = 17 nM in a transactivation assay). It is selective for RORgamma over RORalpha. GSK2981278 inhibits IL-17A and IL-22 protein secretion from isolated human peripheral blood T cells grown under Th17 skewing...
Schlagworte: N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-benzenesulfonamide
Anwendung: Potent, selective ROR gamma inverse agonist
CAS 1474110-21-8
MW: 461.6 D
ab 50,00 €
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SR 2211
SR 2211

Artikelnummer: Cay11972-1

Retinoic acid receptor-related nuclear receptor gamma (RORgamma) plays a central role in T cell differentiation, particularly in the differentiation of pro-inflammatory TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis. SR 2211 selectively binds RORgamma (Ki =...
Schlagworte: 2-fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-alpha,alpha-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol
Anwendung: ROR gamma agonist
CAS 1359164-11-6
MW: 527.5 D
ab 50,00 €
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SR 1001
SR 1001

Artikelnummer: Cay10922-1

Retinoic-acid-receptor-related orphan receptors (ROR) alpha and gamma play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a subset of CD4+ T-cells that contribute to the inflammatory process and have been implicated in the pathology of autoimmune diseases. SR 1001 is a...
Schlagworte: N-(5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)sulfamoyl)-4-methylthiazol-2-yl)acetamide
Anwendung: RORalpha and RORgamma inverse agonist
CAS 1335106-03-0
MW: 477.4 D
ab 43,00 €
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Anti-ROR gamma
Anti-ROR gamma

Artikelnummer: ARG57441.50

Protein function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and...
Schlagworte: Anti-RORC, Anti-NR1F3, Anti-Nuclear receptor ROR-gamma, Anti-Nuclear receptor RZR-gamma, Anti-RAR-related orphan receptor...
Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
520,00 €
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SR1001
SR1001

Artikelnummer: LKT-S6800.5

RORalpha/gamma inverse agonist.
Anwendung: RORalpha/gamma inverse agonist
CAS 1335106-03-0
MW: 477.4 D
ab 82,00 €
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SR 0987
SR 0987

Artikelnummer: Cay19503-1

SR 0987 is an agonist of the T cell-specific isoform of RORgamma (RORgammat, retinoic acid receptor-related orphan receptor-gammat), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA (Cay-10008014) and ionomycin...
Schlagworte: 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide
Anwendung: RORgammat agonist
CAS 303126-97-8
MW: 397.7 D
ab 34,00 €
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Zymostenol
Zymostenol

Artikelnummer: Cay26209-5

Zymostenol is a late-stage precursor in the biosynthesis of cholesterol. It is an agonist of retinoic acid receptor-related orphan receptor gamma (RORgamma) with an EC50 value of 1 µM in a RORgamma coactivator recruitment assay in the presence of ursolic acid (Cay-10072). It increases the number of myelin basic...
Schlagworte: Delta8-Cholesterol, (5alpha)-cholest-8-en-3beta-ol
Anwendung: Late-stage cholesterol biosynthesis precursor, RORgamma agonist
CAS 566-97-2
MW: 386.7 D
ab 141,00 €
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Anti-RORgamma
Anti-RORgamma

Artikelnummer: Cay11003-1

RORgamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. The specific functions of this protein are not known. However, reports suggest that this protein is a ligand activated transcription factor and may be essential for lymphoid organogenesis...
Schlagworte: NR1F3, RAR-Related Orphan Receptor C, Retinoid-Related Orphan Receptor gamma
Anwendung: IHC, WB
Wirt: Rabbit
Spezies-Reaktivität: human
369,00 €
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SR 1555 (hydrochloride)
SR 1555 (hydrochloride)

Artikelnummer: Cay12071-1

Retinoic acid receptor-related nuclear receptor gamma (RORgamma) plays a central role in T cell differentiation, particularly in the development of TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis. SR 1555 is a selective ligand of RORgamma (IC50 = 1 µM). It...
Schlagworte: 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone,...
Anwendung: RORgamma ligand
CAS 2309312-90-9
MW: 496.9 D
ab 43,00 €
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