Anti-phospho-NMDA NR2B Subunit (Ser1166)

Anti-Phospho-Ser1166 NMDA Receptor NR2B Subunit Antibody was prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephosphopeptide affinity columns. Protein function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. [The UniProt Consortium]