Anti-phospho-NMDA NR2B Subunit (Tyr1336)

Anti-NMDA NR2B Subunit pY1336 antibody is directed against NMDA 2B receptor protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Anti-NMDA NR2B Subunit pY1336 antibody is specific for the phophorylated protein. Immunolabeling of the NMDAR NR2B subunit band is blocked by ?-phosphatase treatment. The antibody has been directly tested for reactivity in Western blots rat tissue. Reactivity is expected from the following species based on 100% sequence homology: human, mouse and non-human primates. Protein function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2 influx through them, resulting in an irreversible neuronal death. [The UniProt Consortium]