Anti-p63

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Tumor protein p63 (TP63), also known as TP73L is a protein that in humans is encoded by the TP63 gene. It is a member of the p53 family of transcription factors. This gene encodes for two main isoforms by alternative promoters (TAp63 and dNp63). TP63 has been mostly restricted to its apoptotic function and more recently as the guardian of oocyte integrity. It has been found that the combined loss of TP63 and p73 results in the failure of cells containing functional p53 to undergo apoptosis in response to DNA damage. It is an essential regulator of stem cell maintenance in stratified epithelial tissues. TP63 is also critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis. Protein function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. [The UniProt Consortium]