Anti-p63

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Tumor Protein p63, also known as KET, is a protein that in humans is encoded by the TP63 gene. Yang et al.(1998) described the cloning of tumor protein, which shows strong homology to the tumor suppressor p53 and the p53-related protein p73. By fluorescence in situ hybridization, Yang et al.(1998) localized the human gene to chromosome 3q27-q29. Hibi et al.(2000) stated that p53 homologs known variously as p40, p51, p63, and p73L (Trink etal., 1998, Yang etal., 1998, Osada etal., 1998, Senoo etal., 1998) are isoforms of the same gene, which were then referred to as AIS for 'amplified in squamous cell carcinoma.' Protein function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. [The UniProt Consortium]