Anti-p53

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG59517.100 100 µl - -

6 - 14 Werktage*

624,00 €
 
Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or... mehr
Produktinformationen "Anti-p53"
Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but seems to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). [The UniProt Consortium]
Schlagworte: Anti-P53, Anti-Tp53, Anti-Tumor suppressor p53, Anti-Cellular tumor antigen p53
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG59517

Eigenschaften

Anwendung: ICC, IF, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant fusion protein corresponding to aa. 95-390 of Mouse p53 (NP_035770.2)
MW: 43 kD
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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