Zu "K04451" wurden 662 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-Recombinant Phospho-p53 (Ser15), clone 2D11
Artikelnummer: E-AN301251L.100
TP53(tumor protein p53) Homo sapiens This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis,...
| Schlagworte: | Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor antigen p53,... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-Zebrafish p53 / Tp53 / Tumor protein 53
Artikelnummer: NSJ-RZ1259
0.5mg/ml if reconstituted with 0.2ml sterile DI water. p53, also known as Tumor Protein 53, is a crucial tumor suppressor protein that plays an essential role in maintaining cellular integrity by regulating the cell cycle, promoting DNA repair, and initiating apoptosis in response to stress, including DNA damage,...
| Schlagworte: | Anti-tp53, Anti-Tumor suppressor p53, Anti-Cellular tumor antigen p53, Zebrafish p53 Antibody / Tp53 / Tumor protein 53 |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | zebrafish |
948,00 €
Rezatapopt
Artikelnummer: Cay44358-1
Rezatapopt is a reactivator of p53 containing a tyrosine-to-cysteine substitution at position 220 (p53Y220C). It increases p53Y220C DNA binding by 1.5-fold in a time-resolved FRET (TR-FRET) assay when used at a concentration of 9 nM. Rezatapopt decreases the proliferation of NUGC-3 gastric carcinoma cells (IC50 =...
| Schlagworte: | PC14586, 4-[[3-[4-[[(3S,4R)-3-fluoro-1-methyl-4-piperidinyl]... |
| Anwendung: | P53Y220C reactivator, antineoplastic |
| CAS | 2636846-41-6 |
| MW: | 545,58 D |
ab 49,00 €
Pifithrin-alpha
Artikelnummer: Cay13326-5
Pifithrin-alpha is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 µM and in human umbilical vein endothelial cells at 30 µM. Pifithrin-alpha can also protect cells from DNA damage-induced...
| Schlagworte: | PFT-alpha, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-ethanone, monohydrobromide |
| Anwendung: | p53 inactivator |
| CAS | 63208-82-2 |
| MW: | 367.3 D |
ab 96,00 €
CBL0137
Artikelnummer: Cay19110-1
CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-kappaB with an EC50 of 0.47 µM. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-kappaB and promoting cancer cell death. CBL0137 has broad...
| Schlagworte: | CBLC137, Curaxin 137, 1,1'-[9-[2-[(1-methylethyl)amino]ethyl]-9H-carbazole-3,6-diyl]bis-ethanone |
| Anwendung: | Curaxin, p53 activator, NF-kappaB inhibitor |
| CAS | 1197996-80-7 |
| MW: | 336.4 D |
ab 71,00 €
Anti-p53
Artikelnummer: A300-247A
Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this...
| Schlagworte: | Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor... |
| Anwendung: | WB, IP, IHC, ChIP-Seq, FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
PRIMA-1MET
Artikelnummer: Cay9000487-5
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Cay-63520) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1MET is a methylated derivative of PRIMA-1 that...
| Schlagworte: | APR 246, 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one |
| Anwendung: | Mutant p53 apoptotic function re-activator |
| CAS | 5291-32-7 |
| MW: | 199.3 D |
ab 102,00 €
Anti-p53
Artikelnummer: A300-249A
Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this...
| Schlagworte: | Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
p53 Transcription Factor Assay Kit
Artikelnummer: Cay600020-96
The tumor suppressor protein p53 plays a crucial role in coordinating cellular responses to genotoxic stress and holds many important clinical implications in the treatment of cancer. Cayman's p53 Transcription Factor Assay is a non-radioactive, sensitive method for detecting specific transcription factor DNA...
| Schlagworte: | P53, TP53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, Cellular tumor antigen p53 |
| Anwendung: | p53 detection |
732,00 €
Cyclic Pifithrin-alpha (hydrobromide)
Artikelnummer: Cay14748-10
Pifithrin-alpha (PFT-alpha, Cay-13326) is a reversible inhibitor of p53-dependent transcription and apoptosis. Cyclic PFT-alpha, also known as PFT-beta, is a stable analog of PFT-alpha, formed by the condensation of pifithrin-alpha in solution. It inhibits the growth of the cancer cell lines IGROV-1, A2780, and...
| Schlagworte: | Cyclic PFT-alpha, PFT-beta, Pifithrin-beta, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole,... |
| Anwendung: | PFT-alpha analog, p53-dependent transcription / apoptosis inhibitor |
| CAS | 511296-88-1 |
| MW: | 349.3 D |
ab 85,00 €
Pifithrin-alpha Hydrobromide
Artikelnummer: LKT-P327211.5
p53 inhibitor
| Schlagworte: | Pifithrin-alpha.HBr |
| Anwendung: | p53 inactivator |
| CAS | 63208-82-2 |
| MW: | 367.31 D |
ab 104,00 €
Pifithrin-alpha . hydrobromide
Artikelnummer: AG-CR1-0004-M005
p53 inhibitor, Reversibly blocks p53-dependent transcriptional activation, Tool to combat side effects of cancer therapy, Apoptosis inhibitor.
| Schlagworte: | 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr |
| Anwendung: | p53 inhibitor |
| CAS | 63208-82-2 |
| MW: | 286,4 D |
ab 66,00 €