Anti-p300, clone

Anti-p300, clone
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
100-301-176 100 µl - -

3 - 9 Werktage*

493,00 €
 
Protein function: Functions as histone acetyltransferase and regulates transcription via... mehr
Produktinformationen "Anti-p300, clone"
Protein function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. [The UniProt Consortium]
Schlagworte: Anti-P300, Anti-EP300, Anti-p300 HAT, EC=2.3.1.48, Anti-E1A-associated protein p300, Anti-Histone acetyltransferase p300
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 100-301-176

Eigenschaften

Anwendung: ELISA, WB, IP, EMSA, EMSA
Antikörper-Typ: Monoclonal
Konjugat: No
Wirt: Mouse
Reaktivität: Human
Immunogen: p300 peptide corresponding to a region near the N-terminus of the human protein
Format: Supernatant

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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