Zu "K04498" wurden 138 Artikel gefunden!
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GNE-781
Artikelnummer: Cay36450-10
GNE-781 is an inhibitor of CREB-binding protein (CBP) and histone acetyltransferase p300 (IC50s = 0.94 and 1.2 nM, respectively). It is selective for CBP and p300 over bromodomain-containing protein 4 (BRD4) bromodomain 1, BRD4 bromodomain 2, and bromodomain and PHD finger-containing 1 (BRPF1, IC50s = 5.1, 12, and...
| Schlagworte: | 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-N-methyl-1-(tetrahydro... |
| Anwendung: | CBP / p300 inhibitor |
| CAS | 1936422-33-1 |
| MW: | 525.6 D |
ab 494,00 €
Mouse EP300 (E1A Binding Protein P300) ELISA Kit
Artikelnummer: ELK-ELK6841.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse EP300. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse EP300. Next,...
| Schlagworte: | P300, Ep300, p300 HAT, E1A-associated protein p300, Protein lactyltransferas p300, Histone acetyltransferase p300, Histone... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Human EP300 (E1A Binding Protein P300) ELISA Kit
Artikelnummer: ELK-ELK3343.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human EP300. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human EP300. Next,...
| Schlagworte: | P300, EP300, p300 HAT, E1A-associated protein p300, Protein lactyltransferas p300, Histone acetyltransferase p300, Histone... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Human CREBBP (CREB Binding Protein) ELISA Kit
Artikelnummer: ELK-ELK3772.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CREBBP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CREBBP....
| Schlagworte: | CBP, CREB-binding protein, Histone lysine acetyltransferase CREBBP, Protein-lysine acetyltransferase CREBBP |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
CTB
Artikelnummer: Cay37480-10
CTB is an activator of the histone acetyltransferase p300. It induces acetylation of core histones in HeLa cells when used at a concentration of 200 µM. CTB (85.43 µM) increases p53 acetylation and induces apoptosis in MCF-7 cells.Formal Name: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-benzamide. CAS Number:...
| Schlagworte: | N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-benzamide |
| Anwendung: | p300 activator |
| CAS | 451491-47-7 |
| MW: | 343.7 D |
ab 109,00 €
JQAD1
Artikelnummer: Cay39566-1
JQAD1 is a proteolysis-targeting chimera (PROTAC) composed of the p300 and CREB-binding protein (CBP) inhibitor A-485 (Cay-24119) conjugated to a cereblon (CRBN) ligand. It selectively induces the degradation of p300 over CBP in Kelly MYCN-amplified neuroblastoma cells when used at a concentration of 10 µM for 24...
| Schlagworte: | (R,S)-JQAD1,... |
| Anwendung: | PROTAC, p300 degradation |
| CAS | 2417097-18-6 |
| MW: | 933 D |
ab 113,00 €
C646
Artikelnummer: Cay10549-1
C646 is an inhibitor of the histone acetyltransferase p300 (IC50 = 1.6 µM). It competitively (versus acetyl-CoA) binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases. The action of C646 appears to be irreversible through covalent modification of the enzyme target. It blocks the growth of...
| Schlagworte: | 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyra-zol-1-yl]-benzoic acid |
| Anwendung: | Histone acetyltransferase p300 inhibitor |
| CAS | 328968-36-1 |
| MW: | 445.4 D |
ab 50,00 €
A-485
Artikelnummer: Cay24119-1
A-485 is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM). It decreases acetylated histone H3 lysine 27 (H3K27Ac), but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer (NSCLC), small cell lung cancer, triple-negative...
| Schlagworte: | (1R)-N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methyle... |
| Anwendung: | p300/CBP inhibitor |
| CAS | 1889279-16-6 |
| MW: | 536.5 D |
ab 66,00 €
SGC-CBP30
Artikelnummer: Cay14469-5
cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators. Each contains a bromodomain, which recognizes acetylated lysine residues on target proteins. SGC-CBP30 is a potent inhibitor of CREBBP and EP300 bromodomains (IC50s = 21-69 and...
| Schlagworte: | 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-1H-benzimidazole |
| Anwendung: | CREBBP / EP300 bromodomain inhibitor |
| CAS | 1613695-14-9 |
| MW: | 509 D |
ab 147,00 €
Anti-p300
Artikelnummer: A300-358A
Protein function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232,...
| Schlagworte: | Anti-P300, Anti-EP300, Anti-p300 HAT, Anti-E1A-associated protein p300, Anti-Histone acetyltransferase p300, Anti-Histone... |
| Anwendung: | WB, IP, IHC, ChIP-Seq |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
p300 (KAT3B) Active Human Recombinant Protein
Artikelnummer: BPS-50071
Human E1A binding protein p300, also known as EP300, KAT3B, or RSTS2, GenBank Accession No. NM_001429, a.a. 965-1810, with N-terminal His-GST-tag, MW=125 kDa, expressed in Sf9 cells via a baculovirus expression system. Specific Activity: 4430 pmole/min/µg.
| Schlagworte: | P300, EP300, p300 HAT, E1A-associated protein p300, Protein lactyltransferas p300, Histone acetyltransferase p300, Histone... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 125 kD |
672,00 €
Anti-CBP (IHC)
Artikelnummer: IHC-00023
Protein function: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian...
| Schlagworte: | Anti-CBP, Anti-CREBBP, Anti-CREB-binding protein |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €