Zu "K04498" wurden 179 Artikel gefunden!
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Anti-Recombinant CBP, clone A152
Artikelnummer: E-AN301457L.100
CREB-binding protein (CREBBP/CBP), encoded by the human CREBBP gene, is a transcriptional co-activator. CREBBP functions through interactions with transcription factors, mediated by one or more domains: the nuclear receptor interaction domain (RID), the KIX domain (CREB and MYB interaction domain), the...
| Schlagworte: | Anti-CREBBP, Anti-CREB-binding protein, Anti-Protein lactyltransferas CREBBP, Anti-Histone lysine acetyltransferase... |
| Anwendung: | WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 304,00 €
CCT077791
Artikelnummer: Cay43794-1
CCT077791 is an inhibitor of the histone acetyltransferase p300 (IC50 = 7.3 µM). It is also active against S. aureus, S. epidermidis, and B. subtilis (MICs = 2.5, 0.3, and 2.5 µg/ml, respectively). CCT077791 (10 µM) decreases global protein, histone H3 and H4, and alpha-tubulin acetylation in HCT116 colorectal...
| Schlagworte: | 5-chloro-2-(4-nitrophenyl)-3(2H)-isothiazolone |
| Anwendung: | p300 inhibitor |
| CAS | 748777-47-1 |
| MW: | 256,66 D |
ab 112,00 €
DS9300
Artikelnummer: Cay43812-10
DS9300 is an inhibitor of histone acetyltransferase p300 (IC50 = 28 nM). It inhibits acetylation of lysine 27 on histone H3 (H3K27) in LK-2 cells (IC50 = 54 nM). DS9300 inhibits the growth of VCaP prostate cancer cells (GI50 = 0.6 nM). In vivo, DS9300 (0.3-3 mg/kg) reduces tumor volume in a VCaP castrated mouse...
| Schlagworte: | (2R,4R)-1-[[4,4-difluoro-1-(4-methoxyphenyl)cyclohexyl]carbonyl]-4-fluoro-N-1H-pyrazolo[4,3-b]pyridin-5-yl-2-pyrrolidineca... |
| Anwendung: | p300 (CREBBP) inhibitor |
| CAS | 2259641-46-6 |
| MW: | 501.51 D |
ab 444,00 €
C646
Artikelnummer: Cay10549-1
C646 is an inhibitor of the histone acetyltransferase p300 (IC50 = 1.6 µM). It competitively (versus acetyl-CoA) binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases. The action of C646 appears to be irreversible through covalent modification of the enzyme target. It blocks the growth of...
| Schlagworte: | 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyra-zol-1-yl]-benzoic acid |
| Anwendung: | Histone acetyltransferase p300 inhibitor |
| CAS | 328968-36-1 |
| MW: | 445.4 D |
ab 56,00 €
A-485
Artikelnummer: Cay24119-1
A-485 is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM). It decreases acetylated histone H3 lysine 27 (H3K27Ac), but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer (NSCLC), small cell lung cancer, triple-negative...
| Schlagworte: | (1R)-N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methyle... |
| Anwendung: | p300/CBP inhibitor |
| CAS | 1889279-16-6 |
| MW: | 536.5 D |
ab 73,00 €
SGC-CBP30
Artikelnummer: Cay14469-5
cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators. Each contains a bromodomain, which recognizes acetylated lysine residues on target proteins. SGC-CBP30 is a potent inhibitor of CREBBP and EP300 bromodomains (IC50s = 21-69 and...
| Schlagworte: | 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-1H-benzimidazole |
| Anwendung: | CREBBP / EP300 bromodomain inhibitor |
| CAS | 1613695-14-9 |
| MW: | 509 D |
ab 163,00 €
Anti-p300
Artikelnummer: A300-358A
Protein function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232,...
| Schlagworte: | Anti-P300, Anti-EP300, Anti-p300 HAT, Anti-E1A-associated protein p300, Anti-Histone acetyltransferase p300, Anti-Histone... |
| Anwendung: | WB, IP, IHC, ChIP-Seq |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
p300 (KAT3B) Active Human Recombinant Protein
Artikelnummer: BPS-50071
Human E1A binding protein p300, also known as EP300, KAT3B, or RSTS2, GenBank Accession No. NM_001429, a.a. 965-1810, with N-terminal His-GST-tag, MW=125 kDa, expressed in Sf9 cells via a baculovirus expression system. Specific Activity: 4430 pmole/min/µg.
| Schlagworte: | P300, EP300, p300 HAT, E1A-associated protein p300, Protein lactyltransferas p300, Histone acetyltransferase p300, Histone... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 125 kD |
685,00 €
Anti-CBP (IHC)
Artikelnummer: IHC-00023
Protein function: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian...
| Schlagworte: | Anti-CBP, Anti-CREBBP, Anti-CREB-binding protein |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
I-CBP112 (hydrochloride)
Artikelnummer: Cay14468-1
I-CBP112 is an inhibitor of p300 and CREB-binding protein (CBP) histone acetyltransferases. It binds to the p300 and CBP bromodomains (Kds = 167 and 151 nM, respectively) and is selective for p300 and CBP over BRD4, as well as a panel of 104 nuclear receptors and ion channels and a panel of 32 enzymes at 10 µM....
| Schlagworte: | 1-[7-(3,4-dimethoxyphenyl)-2,3-dihydro-9-[[(3S)-1-methyl-3-piperidinyl]methoxy]-1,4-benzoxazepin-4(5H)-yl]-1-propanone,... |
| Anwendung: | CBP and EP300 inhibitor |
| CAS | 2147701-33-3 |
| MW: | 505.1 D |
ab 67,00 €
HAT Inhibitor II
Artikelnummer: Cay19835-1
HAT Inhibitor II is a cell-permeable, selective inhibitor of the histone acetyltransferase p300 (IC50 = 5 µM). It does not inhibit PCAF or GCN5 acetyltransferases.Formal Name: 2,6-bis[(3-bromo-4-hydroxyphenyl)methylene]-cyclohexanone. CAS Number: 932749-62-7. Synonyms: Histone Acetyltransferase Inhibitor II....
| Schlagworte: | Histone Acetyltransferase Inhibitor II, 2,6-bis[(3-bromo-4-hydroxyphenyl)methylene]-cyclohexanone |
| Anwendung: | Selective, cell-permeable p300/CBP histone acetyltransferase inhibitor |
| CAS | 932749-62-7 |
| MW: | 464.2 D |
ab 56,00 €
Anti-CBP
Artikelnummer: A300-363A-T
Protein function: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian...
| Schlagworte: | Anti-CBP, Anti-CREBBP, Anti-CREB-binding protein |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €