Anti-p-PARP-1 (pS373)

Anti-p-PARP-1 (pS373)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F48734-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F48734-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Catalyzes poly (ADP-ribose) protein modification,... mehr
Produktinformationen "Anti-p-PARP-1 (pS373)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Catalyzes poly (ADP-ribose) protein modification, plays a role in DNA repair and genome stability [RGD]. Protein function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. [The UniProt Consortium]
Schlagworte: Anti-ARTD1, Anti-Adprt, Anti-Parp1, Anti-PARP-1, Anti-ADPRT 1, EC=2.4.2.30, Anti-Poly[ADP-ribose] synthase 1, Anti-Poly [ADP-ribose] polymerase 1, Anti-NAD(+) ADP-ribosyltransferase 1, Anti-ADP-ribosyltransferase diphtheria toxin-like 1, p-PARP-1 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: F48734

Eigenschaften

Anwendung: Dot Blot, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: rat
Immunogen: This p-PARP-1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS373 of rat PARP1.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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