Zu "K24070" wurden 171 Artikel gefunden!
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Fluzoparib
Artikelnummer: Cay36671-10
Fluzoparib is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1, IC50 = 1.46 nM). It induces DNA double-strand breaks in wild-type, but not BRCA2-/-, V-C8 cells, as well as BRCA1-/- MDA-MB-436 cells when used at concentrations of 1 and 10 µM. Fluzoparib inhibits the proliferation of BRCA2-/- V-C8 cells (IC50 =...
| Schlagworte: | 4-[[3-[[5,6-dihydro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phtha... |
| Anwendung: | PARP1 inhibitor |
| CAS | 1358715-18-0 |
| MW: | 472.4 D |
ab 267,00 €
Rucaparib (camsylate)
Artikelnummer: Cay40218-100
Rucaparib is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor. It reduces PARP1 activity in D283 Med medulloblastoma cells by 91.7% when used at a concentration of 1 µM. Rucaparib selectively inhibits the proliferation of MDA-MB-436 breast cancer cells expressing mutant BRCA1 (IC50s = 1.3 µM) over MCF-7 breast...
| Schlagworte: | AG-014699, PF-01367338, (1S,4R)-7,7-dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-methanesulfonic acid, compd. with... |
| Anwendung: | PARP1 inhibitor |
| CAS | 1859053-21-6 |
| MW: | 555.7 D |
ab 80,00 €
YCH1899
Artikelnummer: Cay39737-1
YCH1899 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 50s = 1-14.1 nM). YCH1899 inhibits the proliferation of Capan-1 cells (IC50 = 0.1 nM), as well as Capan-1 cells resistant to the PARP inhibitors talazoparib (BMN 673, Cay-19782) or olaparib (Cay-10621, IC50s = 1.13 and 0.89 nM,...
| Schlagworte: | 4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one |
| Anwendung: | PARP1/PARP2 inhibitor |
| MW: | 549.4 D |
ab 66,00 €
PARP1 assay kit
Artikelnummer: BPS-80551
The PARP1 Chemiluminescent Activity Assay kit is designed to measure PARP1 activity using purified PARP1 or PARP1 extracts. PARP1 is known to catalyze the NAD-dependent addition of poly, ADP-ribose, to histones. The PARP1 assay kit comes in a convenient 96-well format, with purified PARP1 enzyme, histone mixture,...
| Schlagworte: | poly (ADP-ribose) polymerase 1, poly(ADP-ribosyl)transferase, ADPRT, PARP1, |
| Anwendung: | PARP1 assays, HTS |
941,00 €
PARP1, GST-Tag, PAR-Labeled Recombinant
Artikelnummer: BPS-101774
Recombinant human PARP1 (poly-ADP-ribose) polymerase 1), full length, encompassing amino acids 2-1014(end). This construct contains an N-terminal GST-tag followed by a Thrombin Cleavage site. The recombinant protein was affinity purified and PARylated (poly ADP-ribosylated) in vitro.
| Schlagworte: | poly (ADP-ribose) polymerase 1, poly(ADP-ribosyl)transferase, ADPRT, PARP1, PARP-1, PARP1 (GST-Th-2-1014(end))-(PAR) |
| Anwendung: | SDS-PAGE |
| Ursprungsart: | human |
| MW: | 139 + PAR kD |
628,00 €
Senaparib
Artikelnummer: Cay37722-1
Senaparib is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2.Formal Name: 5-fluoro-1-[[4-fluoro-3-[[4-(2-pyrimidinyl)-1-piperazinyl]carbonyl]phenyl]methyl]-2,4(1H,3H)-quinazolinedione. CAS Number: 1401682-78-7. Synonyms: IMP-4297. Molecular Formula: C24H20F2N6O3. Formula Weight: 478.5. Purity: >98%....
| Schlagworte: | IMP-4297, 5-fluoro-1-[[4-fluoro-3-[[4-(2-pyrimidinyl)-1-piperazinyl]carbonyl]phenyl]methyl]-2,4(1H,3H)-quinazolinedione |
| Anwendung: | PARP1 / PARP2 inhibitor |
| CAS | 1401682-78-7 |
| MW: | 478.5 D |
ab 82,00 €
AZD 5305
Artikelnummer: Cay37769-10
AZD 5305 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1, IC50 = 0.003 µM). It is selective for PARP1 over PARP2, PARP3, PARP5a, and PARP6 (IC50s = 1.4, 3.4, >89, and 26 µM, respectively). AZD 5305 inhibits the proliferation of BRCA2-/- DLD-1 colorectal cancer cells (IC50 = 0.002 µM). It induces tumor...
| Schlagworte: | 5-[4-[(7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methyl-2-pyridinecarboxamide |
| Anwendung: | PARP1 inhibitor |
| CAS | 2589531-76-8 |
| MW: | 406.5 D |
ab 175,00 €
PARP1 Colorimetric Assay Kit
Artikelnummer: BPS-80580
The PARP1 Colorimetric Activity Assay Kit is designed to measure PARP1 activity for screening and profiling applications. PARP1 is known to catalyze the NADdependent addition of poly(ADP-ribose) to histones. The key to the PARP1 Colorimetric Activity Assay is the biotinylated substrate. With this kit, only three...
| Schlagworte: | poly(ADP-ribose)polymerase 1, poly(ADP-ribosyl)transferase, ADPRT, PARP1, |
| Anwendung: | Studying enzyme kinetics, screening small molecular inhibitors for drug discovery, HTS applications |
| Spezies-Reaktivität: | human |
956,00 €
Anti-PARP1
Artikelnummer: A301-375A
Protein function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway...
| Schlagworte: | Anti-ADPRT, Anti-PARP1, Anti-ARTD1, Anti-PARP-1, Anti-ADPRT 1, Anti-Poly[ADP-ribose] synthase 1, Anti-Poly [ADP-ribose]... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Anti-PARP1
Artikelnummer: A301-376A
Protein function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway...
| Schlagworte: | Anti-ADPRT, Anti-PARP1, Anti-ARTD1, Anti-PARP-1, Anti-ADPRT 1, Anti-Poly[ADP-ribose] synthase 1, Anti-Poly [ADP-ribose]... |
| Anwendung: | WB, IP, IHC, IHC-IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
PARP1, active human recombinant protein
Artikelnummer: BPS-80501
Active human PARP1 (GenBank Accession No. NM_001618), full length with N-terminal GST tag, MW = 140 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | poly (ADP-ribose) polymerase 1, poly(ADP-ribosyl)transferase, ADPRT, PARP1, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 140 kD |
686,00 €
Anti-PARP1 (IHC)
Artikelnummer: IHC-00279
Protein function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway...
| Schlagworte: | Anti-ADPRT, Anti-PARP1, Anti-ARTD1, Anti-PARP-1, Anti-ADPRT 1, Anti-Poly[ADP-ribose] synthase 1, Anti-Poly [ADP-ribose]... |
| Anwendung: | IHC, IHC-IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €