Anti-MMP12 (Macrophage Metalloelastase, MME, Macrophage Elastase, ME, hME, Matrix Metalloproteinase-

MMP12 is a Metallopeptidase M10A type protease. MMP-12 degrads extracellular matrix components such as elastin and is involved in tissue remodeling processes. MMP12 is a proteolytic enzyme responsible for cleavage of plasminogen to angiotensin. Studies using animal models of acute and chronic pulmonary inflammatory diseases, have given evidences that MMP-12 is an important mediator of the pathogenesis of these diseases. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.