Anti-LYN

LYN is a tyrosine protein kinase that acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. It is involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism. Alternate names for LYN include v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, JTK8, and FLJ26625. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P07948]