Anti-Kv7.1 (KCNQ1, potassium voltage-gated channel, KQT-like subfamily, member 1, IKs producing slow

This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA:1:8000, Western Blot:1-3ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Human Heart lysates, Control Peptide: K0138-03-P: Kv7.1, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.