Zu "K04926" wurden 39 Artikel gefunden!

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Flupirtine (maleate)
Flupirtine (maleate)

Artikelnummer: Cay16674-100

Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ). It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice. Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular...
Schlagworte: N-[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-carbamic acid, ethyl ester, 2Z-butenedioate
Anwendung: KCNQ agonist, NMDA receptor antagonist
CAS 75507-68-5
MW: 420.4 D
ab 50,00 €
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ML-277
ML-277

Artikelnummer: Cay15193-5

Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes. ML-277...
Schlagworte: CID-53347902, (2R)-N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
Anwendung: KCNQ1 activator
CAS 1401242-74-7
MW: 471.6 D
ab 60,00 €
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Anti-KCNQ1
Anti-KCNQ1

Artikelnummer: ARG55375.100

Protein function: Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (PubMed:10646604). Associates with KCNE beta subunits that modulates current kinetics (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505,...
Schlagworte: Anti-KQT-like 1, Anti-Voltage-gated potassium channel subunit Kv7.1, Anti-Potassium voltage-gated channel subfamily KQT...
Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: human
624,00 €
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Anti-KCNQ1, C-terminal
Anti-KCNQ1, C-terminal

Artikelnummer: ARG64865.100

Protein function: Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned...
Schlagworte: Anti-KCNA8, Anti-KCNQ1, Anti-KQT-like 1, Anti-Voltage-gated potassium channel subunit Kv7.1, Anti-Potassium voltage-gated...
Anwendung: ELISA, WB
Wirt: Goat
Spezies-Reaktivität: human
784,00 €
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Anti-KCNQ1, clone S37A-10
Anti-KCNQ1, clone S37A-10

Artikelnummer: 200-301-F82

Anti-KCNQ1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with KCNQ1 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with KCNQ1 from other sources has not been determined. Channels and Transporters research....
Schlagworte: Anti-KCNQ1, Anti-KCNA8, Anti-KQT-like 1, Anti-Voltage-gated potassium channel subunit Kv7.1, Anti-Potassium voltage-gated...
Anwendung: IHC, IFM, WB
Wirt: Mouse
Spezies-Reaktivität: human, mouse, rat
698,00 €
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Anti-KCNQ1
Anti-KCNQ1

Artikelnummer: NSJ-R33938-100UG

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide.
Schlagworte: Anti-KQT-like 1, Anti-Voltage-gated potassium channel subunit Kv7.1, Anti-Potassium voltage-gated channel subfamily KQT...
Anwendung: WB, IHC (paraffin), ELISA (peptide)
Wirt: Goat
Spezies-Reaktivität: human, rat
755,00 €
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Anti-KCNQ1
Anti-KCNQ1

Artikelnummer: E-AB-15154.120

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward...
Schlagworte: Anti-KQT-like 1, Anti-Voltage-gated potassium channel subunit Kv7.1, Anti-Potassium voltage-gated channel subfamily KQT...
Anwendung: WB, IHC, ELISA
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
ab 71,00 €
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XE 991 (hydrochloride)
XE 991 (hydrochloride)

Artikelnummer: Cay14582-50

The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 µM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 µM). It much...
Schlagworte: 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone, dihydrochloride
Anwendung: KCNQ channel blocker
CAS 122955-13-9
MW: 449.4 D
ab 84,00 €
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Linopirdine
Linopirdine

Artikelnummer: Cay19547-10

Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type, Kv7.2/7.3, KCNQ2/3) K+...
Schlagworte: DuP-996, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one
Anwendung: Nootropic, Cognition enhancer
CAS 105431-72-9
MW: 391.5 D
ab 43,00 €
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Chromanol 293B
Chromanol 293B

Artikelnummer: Cay19993-1

Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 µM in Xenopus oocytes expressing rat IKs channels. It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 µM. Chromanol 293B increases the rate and extent of IKs in...
Schlagworte: Chromanol 239B, rel-N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Anwendung: KCNQ1 channel blocker
CAS 163163-23-3
MW: 324.4 D
ab 43,00 €
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Anti-KCNQ1
Anti-KCNQ1

Artikelnummer: E-AB-60659.120

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward...
Schlagworte: Anti-KQT-like 1, Anti-Voltage-gated potassium channel subunit Kv7.1, Anti-Potassium voltage-gated channel subfamily KQT...
Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
ab 198,00 €
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Anti-KCNQ1
Anti-KCNQ1

Artikelnummer: ARG59538.50

Protein function: Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (PubMed:10646604). Associates with KCNE beta subunits that modulates current kinetics (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505,...
Schlagworte: Anti-KQT-like 1, Anti-Voltage-gated potassium channel subunit Kv7.1, Anti-Potassium voltage-gated channel subfamily KQT...
Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: human, rat
520,00 €
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