Anti-DNA Ligase1

This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. Protein function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. [The UniProt Consortium]