Anti-COX-1 (Clone CX111)

Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities. It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail. COX-1 is constitutively expressed in the gastrointestinal tract, kidney, spleen, liver, and lung and localizes to the endoplasmic reticulum. The COX component converts arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) to a hydroperoxyl endoperoxide prostaglandin G2 (PGG2, Cay-17010) and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Cay-17020), the precursor of PGs, thromboxanes, and prostacyclins. COX-1 is the target of many non-steroidal anti-inflammatory drugs (NSAIDs) and is responsible for the undesirable gastrointestinal and renal side effects, such as ulcer formation and reductions in the glomerular filtration rate, respectively. Cayman's COX-1 Monoclonal Antibody (Clone CX111) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: Cyclooxygenase 1, Prostaglandin Endoperoxide Synthase 1, Prostaglandin G/H Synthase 1, Prostaglandin H2 Synthase 1, PGHS-1. Immunogen: Purified ovine COX-1. Clone Designation: CX111. MW: 70 kDa. Formulation: (Request formulation change), 500 µg of purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 0.01% sodium azide. Host: Mouse. Isotype: IgG2b. Applications: IHC, WB. Cross Reactivity: (+) Human COX-2, (+) Ovine COX-2, (-) Mouse COX-2. UniProt Accession #: P05979. Origin: Animal/Mouse.