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Zu "K00509" wurden 181 Artikel gefunden!
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Artikelnummer: Cay70480-5
Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with anticancer activity. It is selective for COX-2 over COX-1 in canine DH82 monocyte/macrophage cells (IC50s = 3.53 and >51.2 µg/ml, respectively). Tolfenamic acid inhibits calcium influx in human polymorphonuclear leukocytes (PMNLs) induced by...
Schlagworte: | 2-[(3-chloro-2-methylphenyl)amino]-benzoic acid |
Anwendung: | Nonsteroidal anti-inflammatory drug |
CAS | 13710-19-5 |
MW: | 261.7 D |
ab 57,00 €
NEU
Artikelnummer: Cay38122-10
Loxoprofen-SRS is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.5 and 0.39 for recombinant human COX-1 and COX-2, respectively) and an active metabolite of the prodrug loxoprofen (Cay-35088). Intravenous administration of loxoprofen-SRS inhibits acetic acid-induced writhing, reduces...
Schlagworte: | 4-[[(1R,2S)-2-hydroxycyclopentyl]methyl]-alphaS-methyl-benzeneacetic acid |
Anwendung: | NSAID, COX inhibitor, active loxoprofen metabolite |
CAS | 83648-76-4 |
MW: | 248.3 D |
ab 34,00 €
Artikelnummer: E-BC-F050.96
Detection principle: Arachidonic acid generates prostaglandins under the catalysis of cyclooxygenase, and under the action of cofactor (heme), cyclooxygenase activates peroxidase activity, converting fluorescent red into fluorescent substance. Performance characteristics: Sample type: animal tissue Sensitivity: 0.03...
Schlagworte: | PHS 1, COX-1, PGHS-1, PGH synthase 1, Cyclooxygenase-1, Prostaglandin H2 synthase 1, Prostaglandin G/H synthase 1,... |
356,00 €
Artikelnummer: Cay38116-100
4-Biphenylacetic acid is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of the prodrug fenbufen (Cay-28851). It inhibits prostaglandin E2 (PGE2, Cay-14010) synthesis in a cell-free assay (IC50 = 3.2 µM). In vivo, 4-biphenylacetic acid (2 mg/kg) suppresses UV-induced erythema in guinea pigs....
Schlagworte: | p-Biphenylacetic Acid, Cl-83544, Felbinac, LY601017, NSC 16284, [1,1'-biphenyl]-4-acetic acid |
Anwendung: | NSAID, active fenbufen metabolite |
CAS | 5728-52-9 |
MW: | 212.2 D |
ab 47,00 €
Artikelnummer: Cay39808-10
Benzydamine is a non-steroidal anti-inflammatory drug (NSAID). It decreases the viability of THP-1 monocytes, Saos-2 osteosarcoma, and HGF-1 gingival cancer cells (IC50s = 59.08, 30.79, and 52.06 µg/ml, respectively). Benzydamine (10 µg/ml) reduces LPS-induced increases in the levels of IL-6 and TNF-alpha secreted...
Schlagworte: | N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-1-propanamine, monohydrochloride |
Anwendung: | NSAID, COX inhibitor |
CAS | 132-69-4 |
MW: | 345.9 D |
ab 39,00 €
Artikelnummer: Cay40112-1
Benzydamine-d6 is intended for use as an internal standard for the quantification of benzydamine by GC- or LC-MS. Benzydamine is a non-steroidal anti-inflammatory drug (NSAID). It inhibits LPS-induced TNF-alpha and IL-1beta production in isolated human peripheral blood mononuclear cells (PBMCs) when used at...
Schlagworte: | N,N-dimethyl-3-[[1-(phenylmethyl-d6)-1H-indazol-3-yl]oxy]-1-propanamine, monohydrochloride |
Anwendung: | GC-MS, LC-MS internal standard, quantification, non-steroidal anti-inflammatory drug (NSAID) |
CAS | 1246817-20-8 |
MW: | 351.9 D |
267,00 €
Artikelnummer: Cay70340-1
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex(TM)) and rofecoxib (Vioxx(TM)). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect...
Schlagworte: | 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole |
Anwendung: | COX-1 inhibitor |
CAS | 188817-13-2 |
MW: | 352.7 D |
ab 26,00 €
Artikelnummer: Cay701230-96
The COX (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2a. This assay includes recombinant human COX-1 and COX-2 and is an excellent tool...
Schlagworte: | Cyclooxygenase (human) Inhibitor Screening Assay Kit |
Anwendung: | Inhibitor screening |
Spezies-Reaktivität: | human |
584,00 €
Artikelnummer: ELK-ELK1858.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PTGS1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PTGS1. Next,...
Schlagworte: | COX-1, PHS 1, PGHS-1, PGH synthase 1, Cyclooxygenase-1, Prostaglandin H2 synthase 1, Prostaglandin G/H synthase 1,... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-EA023.100
Cyclooxygenase-1 (COX-1), also known as prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 or prostaglandin H2 synthase 1, is an enzyme that in humans is encoded by the PTGS1 gene. There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible...
Schlagworte: | Anti-COX-1, Anti-PHS 1, Anti-PGHS-1, Anti-PGH synthase 1, Anti-Cyclooxygenase-1, Anti-Prostaglandin H2 synthase 1,... |
Anwendung: | WB, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
283,00 €
Artikelnummer: Cay701070-96
The COX-1 (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2alpha. This assay includes recombinant human COX-1 and is an excellent tool for...
Schlagworte: | Cyclooxygenase 1 |
Anwendung: | Inhibitor screening |
Spezies-Reaktivität: | human |
584,00 €
Artikelnummer: Cay37554-10
(+)-Naproxen is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor. It inhibits COX-1 and COX-2 in COS-1 cells expressing the human enzymes (IC50s = 4.8 and 28.4 µM, respectively). (+)-Naproxen inhibits thromboxane B2 (TXB2, Cay-19030) and prostaglandin E2 (PGE2, Cay-14010) production ex vivo in...
Schlagworte: | (S)-Naproxen, CG 3117, (alphaS)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid, monosodium salt |
Anwendung: | NSAID, COX inhibitor |
CAS | 26159-34-2 |
MW: | 252.2 D |
ab 81,00 €