Zu "K00509" wurden 243 Artikel gefunden!
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COX-1 (human) Inhibitor Screening Assay Kit
Artikelnummer: Cay701070-96
The COX-1 (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2alpha. This assay includes recombinant human COX-1 and is an excellent tool for...
| Schlagworte: | Cyclooxygenase 1 |
| Anwendung: | Inhibitor screening |
| Spezies-Reaktivität: | human |
647,00 €
COX (human) Inhibitor Screening Assay Kit
Artikelnummer: Cay701230-96
The COX (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2a. This assay includes recombinant human COX-1 and COX-2 and is an excellent tool...
| Schlagworte: | Cyclooxygenase (human) Inhibitor Screening Assay Kit |
| Anwendung: | Inhibitor screening |
| Spezies-Reaktivität: | human |
647,00 €
SC-560
Artikelnummer: Cay70340-1
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex(TM)) and rofecoxib (Vioxx(TM)). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect...
| Schlagworte: | 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole |
| Anwendung: | COX-1 inhibitor |
| CAS | 188817-13-2 |
| MW: | 352.7 D |
ab 29,00 €
COX-1 (ovine)
Artikelnummer: Cay60100-5
Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities. It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail. COX-1 is constitutively expressed in the gastrointestinal tract, kidney,...
| Schlagworte: | COX1, PTGS1, COX-1, PHS 1, COX-1, PHS 1, PGHS-1, PGHS-1, PGH synthase 1, PGH synthase 1, Cyclooxygenase-1,... |
| Anwendung: | Enzyme activity |
1.215,00 €
Diclofenac (epolamine)
Artikelnummer: Cay44224-10
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester (Cay-22218) and diclofenac amide (Cay-21969). Diclofenac inhibits release of arachidonic acid (Cay-90010,...
| Schlagworte: | 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, compd. with 1-pyrrolidineethanol |
| Anwendung: | NSAID, COX inhibitor |
| CAS | 119623-66-4 |
| MW: | 411,32 D |
ab 52,00 €
COX Colorimetric Inhibitor Screening Assay Kit
Artikelnummer: Cay701050-192
The COX Colorimetric Inhibitor Screening Assay measures the peroxidase component of cyclooxygenases. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) at 590 nm. Inhibition of COX activity, measured by TMPD oxidation, by a...
| Anwendung: | Inhibitor screening |
1.224,00 €
trans-Resveratrol
Artikelnummer: Cay70675-500
trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 µM, respectively) but not COX-2 (EC50s = >100 µM and 85 µM, respectively). trans-Resveratrol (200 µM) also activates...
| Schlagworte: | (E)-Resveratrol, 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol |
| Anwendung: | COX-1 inhibitor |
| CAS | 501-36-0 |
| MW: | 228.2 D |
ab 44,00 €
(±)-Flurbiprofen
Artikelnummer: Cay70250-1
A non-selective COX inhibitor (IC50s = 0.04 and 0.51 µM for COX-1 and COX-2, respectively), reduces carrageenan-induced hind paw edema and yeast-induced fever in rats from 0.3-4.8 mg/kg, reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis, reduces tumor weight and...
| Schlagworte: | Ansaid, (±)-2-fluoro-a-methyl-[1,1'-biphenyl]-4-acetic acid |
| Anwendung: | Non-selective COX inhibitor |
| CAS | 5104-49-4 |
| MW: | 244.3 D |
ab 49,00 €
Phenylbutazone
Artikelnummer: Cay70400-1
An NSAID and inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide), inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide), reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis...
| Schlagworte: | 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione |
| Anwendung: | NSAID, COX peroxidase activity inhibitor |
| CAS | 50-33-9 |
| MW: | 308.4 D |
ab 23,00 €
Meclofenamate (sodium salt)
Artikelnummer: Cay70550-1
A time-dependent, non-specific COX inhibitor with IC50 values of 1.5 and 9.7 µM for human recombinant COX-1 and COX-2, respectively. Formulation: A crystalline solid. InChI: InChI=1S/C14H11Cl2NO2.Na/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19,/h2-7,17H,1H3,(H,18,19),/q,+1/p-1. InChIKey:...
| Schlagworte: | Meclofenamic Acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, monosodium salt |
| Anwendung: | Time-dependent, non-specific competitive COX inhibitor |
| CAS | 6385-02-0 |
| MW: | 318.1 D |
ab 83,00 €
Diclofenac (sodium salt)
Artikelnummer: Cay70680-100
An NSAID and a COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively), inhibits A23187-induced release of arachidonic acid in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 µM, respectively), inhibits carrageenan-induced paw edema in rats. Formulation: A...
| Schlagworte: | 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, monosodium salt |
| Anwendung: | NSAID, COX inhibitor |
| CAS | 15307-79-6 |
| MW: | 318.1 D |
ab 48,00 €
(+)-Naproxen
Artikelnummer: Cay70290-1
An NSAID and COX inhibitor, inhibits COX-1 and COX-2 in COS-1 cells expressing the human enzymes (IC50s = 4.8 and 28.4 µM, respectively), inhibits TXB2 and PGE2 production ex vivo in isolated rat blood (IC50s = 5 and 13 µM, respectively). Formulation: A crystalline solid. InChI:...
| Schlagworte: | (S)-Naproxen, CG 3117, (aS)-6-methoxy-a-methyl-2-naphthaleneacetic acid |
| Anwendung: | NSAID, COX inhibitor |
| CAS | 22204-53-1 |
| MW: | 230.3 D |
ab 30,00 €