Anti-Beta Tubulin

Tubulin is one of several members of a small family of globular proteins and is the major constituent of microtubules. The most common members of the tubulin family are alpha-tubulin and beta-tubulin. It appears to play an important role in the formation of platelet. It is involved in the pathogenesis of Cortical dysplasia, complex, with other brain malformations 6 (CDCBM6) and distal hereditary motor neuropathy, type 2. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. It is expressed exclusively in megakaryocytes and platelets in humans. Protein function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [The UniProt Consortium]