Zu "K07375" wurden 502 Artikel gefunden!
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Nocodazole
Artikelnummer: Cay13857-5
Nocodazole is an antimitotic agent. It increases tubulin GTP hydrolysis four-fold and induces tubulin depolymerization. Nocodazole (4 µg/ml) halts the cell cycle in the mitotic phase and synchronizes WI38 cells in the G2/M phase. It also decreases neuronal mitochondrial transport and density in a transgenic...
| Schlagworte: | NSC 238159, Oncodazole, R 17934, N-[6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester |
| Anwendung: | Microtubule function studies, cell cycle arrest |
| CAS | 31430-18-9 |
| MW: | 301.3 D |
ab 57,00 €
NEU
Avanbulin
Artikelnummer: Cay45297-10
Avanbulin is an inhibitor of microtubule polymerization and is the active metabolite of the lysine-containing prodrug lisavanbulin. Avanbulin binds to unassembled tubulin at the binding site for colchicine (Cay9000760) and inhibits tubulin assembly (IC50 = 1.4 µM). It is cytotoxic to GBM6 and GBM9 glioblastoma cells...
| Schlagworte: | 3-[[4-[1-[2-(4-aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-yl]amino]-propanenitrile |
| Anwendung: | Microtubule polymerization inhibitor, antineoplastic |
| CAS | 798577-91-0 |
| MW: | 387.4 D |
ab 91,00 €
Paclitaxel
Artikelnummer: AG-CN2-0045-M005
Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase....
| Schlagworte: | Taxol, BMS 181339-01, NSC 125973 |
| Anwendung: | Apoptosis Inducer |
| Wirt: | Taxus brevifolia |
| CAS | 33069-62-4 |
| MW: | 853,9 D |
ab 22,00 €
TUBB2A Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-02261-10ug
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
| Schlagworte: | Tubulin beta class IIa , Tubulin beta-2A chain , TUBB2 , TUBB2A |
| MW: | 51.9 kD |
ab 81,00 €
Tubb5 Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPH-04463-100ug
Description: Tubb5 Protein, Mouse, Recombinant (His) is expressed in E. coli. The accession number is P99024.
| Schlagworte: | Tubulin beta-5 chain , Tubb5 |
| MW: | 56.6 kD |
ab 134,00 €
Anti-Recombinant beta II Tubulin, clone A592
Artikelnummer: E-AN301880L.100
Beta-tubulin is a protein that forms the backbone of cells. Tubulin can be divided into several kinds of Tubulin, including alpha, beta, gamma, delta, and epsilon, among which alpha -tubulin and beta -tubulin can form heterodimers and are the two most important Tubulin for microtubule formation. The molecular...
| Schlagworte: | Anti-TUBB2B, Anti-Tubulin beta-2B chain, Recombinant beta II Tubulin Monoclonal Antibody |
| Anwendung: | WB, IHC, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 304,00 €
Anti-Recombinant beta III Tubulin, clone A651
Artikelnummer: E-AN301935L.100
Beta III Tubulin (TUBB3) is one of six beta-tubulin isoforms and is expressed highly during fetal and postnatal development (axon guidance and maturation). Its expression levels decrease in the adult central nervous system (CNS) but remain high in the peripheral nervous system (PNS). Microtubules enriched in...
| Schlagworte: | Anti-TUBB3, Anti-Tubulin beta-III, Anti-Tubulin beta-4 chain, Anti-Tubulin beta-3 chain, Recombinant beta III Tubulin... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 304,00 €
Anti-Recombinant beta IV Tubulin, clone A657
Artikelnummer: E-AN301941L.100
Beta IV Tubulin (TUBB4) is a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in TUBB4 cause hypomyelinating leukodystrophy and autosomal dominant torsion dystonia. Alternate splicing of...
| Schlagworte: | Anti-TUBB4A, Anti-Tubulin 5 beta, Anti-Tubulin beta-4 chain, Anti-Tubulin beta-4A chain, Recombinant beta IV Tubulin... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 304,00 €
Monomethyl auristatin E
Artikelnummer: TGM-T6897-10mg
Description: Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity. Target: Microtubule Associated, Apoptosis, ADC Cytotoxin. Smiles:...
| Schlagworte: | Vedotin, MMAE |
| Anwendung: | Targets tubulin beta (TUBB) |
| CAS | 474645-27-7 |
| MW: | 717.98 D |
ab 39,00 €
Paclitaxel
Artikelnummer: Cay10461-25
Paclitaxel, a potent disruptor of microtubules derived from the bark of the Pacific yew tree, is widely used as a chemotherapeutic compound. Tested against a panel of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas, paclitaxel demonstrates IC50 values...
| Schlagworte: | NSC 125973, betaS-(benzoylamino)-alphaR-hydroxy-benzenepropanoic acid,... |
| Anwendung: | Apotosis inducer |
| CAS | 33069-62-4 |
| MW: | 853.9 D |
ab 55,00 €
Anti-Tubulin (glycylated) (Gly-pep1)
Artikelnummer: AG-25B-0034-C100
Polyclonal Antibody. This antibody recognizes mono or bi-glycylated Tubulins. The activity of glycylating enzymes (TTLL3 and TTLL8) in cultured cells leads mainly to the modification of alpha- and beta-tubulin, but also of other, yet unidentified protein substrates also detected by the antibody Gly-pep1. In...
| Schlagworte: | Anti-TUBB2, Anti-TUBB2A, Anti-Tubulin beta-2A chain, Anti-Tubulin beta class IIa |
| Anwendung: | ICC, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | dog, human, mouse |
418,00 €
Vinblastine (sulfate)
Artikelnummer: Cay11762-10
Vinblastine, derived from C. roseus, also known as V. rosea, a Madagascar periwinkle, is an antimicrotubule drug used to treat certain cancers, including Hodgkin's lymphoma, non-small cell lung, breast, head and neck, and testicular cancer. Like its chemical analog vincristine, vinblastine binds tubulin, inhibiting...
| Schlagworte: | 29060LE, Alkaban-AQ, Exal, NSC 49842, Rozevinsulfate, Velban(R), Velsar, Vincaleukoblastinesulfate, VLB,... |
| Anwendung: | Vincristine analog, Cancer studies |
| CAS | 143-67-9 |
| MW: | 909.1 D |
ab 89,00 €