Anti-ALK-1 (Clone: ABM43C4)

Anti-ALK-1 (Clone: ABM43C4)
Anti-ALK-1 (Clone: ABM43C4)
   
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Rabatt Preis
ABE-10-7542-100 100 µg -

3 - 11 Werktage*

15 %
418,00 €
355,30 €
 
ALK-1 or Activin receptor-like kinase-1 is a type I cell surface receptor for the TGF-beta... mehr
Produktinformationen "Anti-ALK-1 (Clone: ABM43C4)"
ALK-1 or Activin receptor-like kinase-1 is a type I cell surface receptor for the TGF-beta (transforming growth factor-beta) super family of proteins. It is expressed predominantly in endothelial cells with moderate expression in smooth muscle cells, myofibroblast, hepatic stellate cells, chondrocytes, monocytes, myoblasts, macrophages and fibroblasts. ALK-1 plays a pivotal role in vascular remodelling and angiogenesis. More specifically its key function is in arterial/venous differentiation during embryonic vascular development. Mutations in ALK-1 gene (12q11-14) causes HHT2 (Hereditary Haemorrhagic Telangiectasia type 2), an autosomal dominant multisystem vascular dysplasia caused by a haploinsufficiency mechanism. Protein function: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. [The UniProt Consortium]
Schlagworte: Anti-SKR3, Anti-TSR-I, Anti-ALK-1, Anti-ACVRL1, Anti-ACVRLK1, EC=2.7.11.30, Anti-Activin receptor-like kinase 1, Anti-TGF-B superfamily receptor type I, Anti-Serine/threonine-protein kinase receptor R3, Monoclonal Antibody to ALK-1 (Clone: ABM43C4)
Hersteller: Abeomics
Hersteller-Nr: 10-7542

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Monoclonal
Klon: ABM43C4
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: A partial length recombinant ALK-1 protein (amino acids 310-503) was used as the immunogen for this antibody
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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Anti-ACVRL1 Anti-ACVRL1
624,00 €
Anti-ACVRL1 Anti-ACVRL1
624,00 €
-15 %
Rabattaktion
Anti-ALK1 Anti-ALK1
387,00 € 328,95 €
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