Zu "K13594" wurden 56 Artikel gefunden!
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Human ALK1 (Activin Receptor Like Kinase 1) ELISA Kit
Artikelnummer: ELK-ELK2667.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ALK1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ALK1. Next,...
| Schlagworte: | SKR3, ALK-1, TSR-I, ACVRL1, ACVRLK1, EC=2.7.11.30, Activin receptor-like kinase 1, TGF-B superfamily receptor type I,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
LDN-193189
Artikelnummer: Cay11802-1
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-beta superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are...
| Schlagworte: | 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Anwendung: | BMP type I receptor inhibitor |
| CAS | 1062368-24-4 |
| MW: | 406.5 D |
ab 44,00 €
K02288
Artikelnummer: Cay16678-1
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based...
| Schlagworte: | 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-phenol |
| Anwendung: | ALK1 / ALK2 inhibitor |
| CAS | 1431985-92-0 |
| MW: | 352.4 D |
ab 50,00 €
LDN-193189 (hydrochloride)
Artikelnummer: Cay19396-10
LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over...
| Schlagworte: | DM-3189, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, dihydrochloride |
| Anwendung: | ALK1 / ALK2 / ALK3 / ALK6 inhibitor |
| CAS | 1435934-00-1 |
| MW: | 479.4 D |
ab 32,00 €
ALK1, GST-tag
Artikelnummer: BPS-40018
Recombinant human activin receptor-like kinase 1, or ALK1, (a.a. 144-end), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system. The gene accession number is NM_000020.
| Schlagworte: | SKR3, ALK-1, TSR-I, ACVRL1, ACVRLK1, EC=2.7.11.30, Activin receptor-like kinase 1, TGF-B superfamily receptor type I,... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 64 kD |
862,00 €
Anti-ALK1
Artikelnummer: NSJ-R34483-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Activin receptor-like kinase 1, ACVRL1. This protein is different than the similarily named protein ALK (anaplastic lymphoma kinase), GeneID 238. Protein function: Type I receptor for TGF-beta...
| Schlagworte: | Anti-SKR3, Anti-ALK-1, Anti-TSR-I, Anti-ACVRL1, Anti-ACVRLK1, EC=2.7.11.30, Anti-Activin receptor-like kinase 1,... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
755,00 €
AP26113
Artikelnummer: Cay19778-10
AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50 12087), ceritinib (Cay-19374), and CH5424802 (Cay-18516). AP26113 blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants.Formal Name:...
| Schlagworte: | Brigatinib,... |
| Anwendung: | Dual ALK / EGFR inhibitor |
| CAS | 1197953-54-0 |
| MW: | 584.1 D |
ab 60,00 €
LDK378
Artikelnummer: LKT-L1340.1
LDK378 is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC).
| Schlagworte: | LDK-378, 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine |
| Anwendung: | ALK1 inhibitor |
| CAS | 1032900-25-6 |
| MW: | 558.13 D |
ab 79,00 €
ML-347
Artikelnummer: Cay17640-1
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. ML-347 is a 5-quinoline compound...
| Schlagworte: | LDN193719, 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Anwendung: | ALK1 / ALK2 inhibitor |
| CAS | 1062368-49-3 |
| MW: | 352.4 D |
ab 50,00 €
Anti-ALK1
Artikelnummer: NSJ-F50788-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain,...
| Schlagworte: | Anti-SKR3, Anti-ALK-1, Anti-TSR-I, Anti-ACVRL1, Anti-ACVRLK1, EC=2.7.11.30, Anti-Activin receptor-like kinase 1,... |
| Anwendung: | WB, FC, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 326,00 €
ALK1 Kinase Assay Kit
Artikelnummer: BPS-79549
The ALK1 Kinase Assay Kit is designed to measure ALK1 kinase activity for screening and profiling applications using ADP-Glo(R) Kinase Assay as a detection reagent. The ALK1 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant ALK1 enzyme, ALK1 substrate, ATP and kinase assay...
| Schlagworte: | activin receptor-like kinase 1, ACVRL1, |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
789,00 €
Anti-ALK-1 (Clone: ABM43C4)
Artikelnummer: ABE-10-7542-25
ALK-1 or Activin receptor-like kinase-1 is a type I cell surface receptor for the TGF-beta (transforming growth factor-beta) super family of proteins. It is expressed predominantly in endothelial cells with moderate expression in smooth muscle cells, myofibroblast, hepatic stellate cells, chondrocytes, monocytes,...
| Schlagworte: | Anti-SKR3, Anti-TSR-I, Anti-ALK-1, Anti-ACVRL1, Anti-ACVRLK1, EC=2.7.11.30, Anti-Activin receptor-like kinase 1,... |
| Anwendung: | IHC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
149,00 €