Zu "K13594" wurden 86 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Human ACVRL1 ELISA Kit
Artikelnummer: ARG81942.96
Protein function: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type...
| Schlagworte: | SKR3, TSR-I, ALK-1, ACVRL1, ACVRLK1, EC=2.7.11.30, Activin receptor-like kinase 1, TGF-B superfamily receptor type I,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.118,00 €
Mouse ACVRL1 ELISA Kit
Artikelnummer: ARG81943.96
Protein function: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type...
| Schlagworte: | SKR3, TSR-I, ALK-1, Acvrl1, Acvrlk1, EC=2.7.11.30, Activin receptor-like kinase 1, TGF-B superfamily receptor type I,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
1.118,00 €
ALK-1/Activin RL1, His, Human
Artikelnummer: GSC-Z05005-100
Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1,...
| Schlagworte: | ACVRL1, Activin receptor type-1-like, Activin receptor-like kinase 1, TGF-B superfamily receptor type I,... |
| Ursprungsart: | human |
| MW: | 11.5 kD |
ab 403,00 €
LDN-193189
Artikelnummer: Cay11802-1
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-beta superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are...
| Schlagworte: | 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Anwendung: | BMP type I receptor inhibitor |
| CAS | 1062368-24-4 |
| MW: | 406.5 D |
ab 45,00 €
Anti-ALK-1/ACVRL1 Monoclonal Recombinant Antibody
Artikelnummer: E-AN300174P.100
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The...
| Schlagworte: | SKR3, TSR-I, ALK-1, ACVRL1, ACVRLK1, EC=2.7.11.30, Activin receptor type-1-like, Activin receptor-like kinase 1, TGF-B... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
462,00 €
K02288
Artikelnummer: Cay16678-1
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based...
| Schlagworte: | 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-phenol |
| Anwendung: | ALK1 / ALK2 inhibitor |
| CAS | 1431985-92-0 |
| MW: | 352.4 D |
ab 56,00 €
LDN-193189 (hydrochloride)
Artikelnummer: Cay19396-10
LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over...
| Schlagworte: | DM-3189, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, dihydrochloride |
| Anwendung: | ALK1 / ALK2 / ALK3 / ALK6 inhibitor |
| CAS | 1435934-00-1 |
| MW: | 479.4 D |
ab 41,00 €
ALK1 (ACVRL1), GST-tag Recombinant
Artikelnummer: BPS-40018
Recombinant human activin receptor-like kinase 1, or ALK1, (a.a. 144-end), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system. The gene accession number is NM_000020.
| Schlagworte: | SKR3, ALK-1, TSR-I, ACVRL1, ACVRLK1, EC=2.7.11.30, Activin receptor-like kinase 1, TGF-B superfamily receptor type I,... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 64 kD |
901,00 €
Anti-ALK1
Artikelnummer: NSJ-R34483-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Activin receptor-like kinase 1, ACVRL1. This protein is different than the similarily named protein ALK (anaplastic lymphoma kinase), GeneID 238. Protein function: Type I receptor for TGF-beta...
| Schlagworte: | Anti-SKR3, Anti-ALK-1, Anti-TSR-I, Anti-ACVRL1, Anti-ACVRLK1, EC=2.7.11.30, Anti-Activin receptor-like kinase 1,... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
AP26113
Artikelnummer: Cay19778-10
AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50 12087), ceritinib (Cay-19374), and CH5424802 (Cay-18516). AP26113 blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants.Formal Name:...
| Schlagworte: | Brigatinib,... |
| Anwendung: | Dual ALK / EGFR inhibitor |
| CAS | 1197953-54-0 |
| MW: | 584.1 D |
ab 67,00 €
LDK378
Artikelnummer: LKT-L1340.1
LDK378 is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC).
| Schlagworte: | LDK-378, 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine |
| Anwendung: | ALK1 inhibitor |
| CAS | 1032900-25-6 |
| MW: | 558.13 D |
ab 83,00 €
ML-347
Artikelnummer: Cay17640-1
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. ML-347 is a 5-quinoline compound...
| Schlagworte: | LDN193719, 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Anwendung: | ALK1 / ALK2 inhibitor |
| CAS | 1062368-49-3 |
| MW: | 352.4 D |
ab 56,00 €