Zu "K13594" wurden 77 Artikel gefunden!
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LDN-193189
Artikelnummer: Cay11802-1
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-beta superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are...
| Schlagworte: | 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Anwendung: | BMP type I receptor inhibitor |
| CAS | 1062368-24-4 |
| MW: | 406.5 D |
ab 47,00 €
M4K2234
Artikelnummer: TGM-T74660-2mg
Description: M4K2234 (compound 26b), an ALK2 inhibitor, demonstrates selective inhibition of ALK2 and ALK5 with IC50 values of 5 nM and 2144 nM, respectively. Serving as a chemical probe for ALK1 and ALK2 protein kinases, M4K2234 holds potential for cancer research applications [1]. Target: Others. Smiles:...
| Anwendung: | ALK1 / ALK2 inhibitor |
| CAS | 2421141-51-5 |
| MW: | 462.56 D |
120,00 €
ALK-1 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-01168-100ug
Description: ALK-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.3 kDa and the accession number is A0A0S2Z310.
| Schlagworte: | SKR3, HHT, ACVRLK1, TSR-I, ORW2, HHT2, ALK1, ALK-1, activin A receptor type II-like 1 |
| MW: | 12.3 kD |
ab 319,00 €
ALK-1 Protein, Human, Recombinant (hFc)
Artikelnummer: TGM-TMPY-00650-100ug
Description: ALK-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.4 kDa and the accession number is A0A0S2Z310.
| Schlagworte: | SKR3, ORW2, TSR-I, ACVRLK1, HHT2, activin A receptor type II-like 1, ALK1, ALK-1, HHT |
| MW: | 37.4 kD |
ab 497,00 €
ALK-1 Protein, Mouse, Recombinant (His & hFc)
Artikelnummer: TGM-TMPY-00662-200ug
Description: ALK-1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 39 kDa and the accession number is Q61288.
| Schlagworte: | AI427544, activin A receptor type II-like 1, Alk1, AI115505, Acvrlk1 |
| MW: | 39 kD |
903,00 €
ALK-1 Protein, Rat, Recombinant (His & hFc)
Artikelnummer: TGM-TMPY-00757-200ug
Description: ALK-1 Protein, Rat, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.7 kDa and the accession number is A6KCN1.
| Schlagworte: | activin A receptor type II-like 1 |
| MW: | 38.7 kD |
903,00 €
ALK-1 Protein, Mouse, Recombinant (hFc)
Artikelnummer: TGM-TMPJ-00304-10ug
Description: Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high...
| Schlagworte: | TSR-I, Serine/threonine-protein kinase receptor R3, ALK-1, SKR3, activin A receptor, activin A receptor type II-like 1,... |
| MW: | 60 kD |
ab 37,00 €
K02288
Artikelnummer: TGM-T1914-100mg
Description: K 02288 is a novel small molecule inhibitor of ALK1/2/3/6. Target: TGF-beta/Smad, ALK. Smiles: COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1cccc(O)c1. References: Sanvitale CE, et al. PLoS One. 2013, 8(4), e62721.
| Schlagworte: | K 02288 |
| Anwendung: | ALK1 / ALK2 inhibitor |
| CAS | 1431985-92-0 |
| MW: | 352.38 D |
ab 34,00 €
LDN193189
Artikelnummer: TGM-T1935-100mg
Description: LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6). Target: ALK, TGF-beta/Smad. Smiles: C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12. References: Yu PB, et al. BMP type I...
| Schlagworte: | DM-3189, LDN 193189, LDN-193189 |
| Anwendung: | BMP type I receptor inhibitor |
| CAS | 1062368-24-4 |
| MW: | 406.48 D |
ab 42,00 €
ML347
Artikelnummer: TGM-T1943-100mg
Description: ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3. Target: ALK, TGF-beta/Smad. Smiles: COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12. References: Engers DW, et al. Bioorg Med Chem Lett. 2013, 23(11), 3248-3252.
| Schlagworte: | LDN 193719 |
| Anwendung: | ALK1 / ALK2 inhibitor |
| CAS | 1062368-49-3 |
| MW: | 352.39 D |
ab 34,00 €
ACVRL1 Protein (His Tag) (recombinant human)
Artikelnummer: E-PDMH100250.100
Sequence: Asp22-Gln118. Fusion tag: C-His Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Observed Molecular Mass: 25-30 kDa. Protein function: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with an other type I receptors a high degree of...
| Schlagworte: | SKR3, ALK-1, TSR-I, ACVRL1, ACVRLK1, EC=2.7.11.30, Activin receptor-like kinase 1, TGF-B superfamily receptor type I,... |
| Exprimiert in: | Mammalian |
| Ursprungsart: | human |
ab 304,00 €
ACVRL1 Protein (His Tag) (recombinant mouse)
Artikelnummer: E-PDMM100096.100
Sequence: Asp23-Pro119. Fusion tag: C-His Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Observed Molecular Mass: 20-30 kDa. Protein function: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with an other type I receptors a high degree of...
| Schlagworte: | SKR3, ALK-1, TSR-I, Acvrl1, Acvrlk1, EC=2.7.11.30, Activin receptor-like kinase 1, TGF-B superfamily receptor type I,... |
| Exprimiert in: | Mammalian |
| Ursprungsart: | mouse |
ab 304,00 €