Anti-53BP1

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A300-272A-T 20 µl (2 blots) -

6 - 10 Werktage*

131,00 €
A300-272A-M 100 µl (10 blots) -

6 - 10 Werktage*

313,00 €
A300-272A 100 µl (100 µg) -

6 - 10 Werktage*

465,00 €
 
Protein function: Double-strand break (DSB) repair protein involved in response to DNA damage,... mehr
Produktinformationen "Anti-53BP1"
Protein function: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR. In contrast, it is not required for classic NHEJ and V(D)J recombination. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). [The UniProt Consortium]
Schlagworte: Anti-53BP1, Anti-p53BP1, Anti-p53-binding protein 1, Anti-TP53-binding protein 1
Hersteller: Bethyl Laboratories
Hersteller-Nr: A300-272A

Eigenschaften

Anwendung: WB, IP, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse
Immunogen: synthetic peptide. The epitope recognized by A300-272A-T maps to a region between residues 350 and 400 of human tumor protein p53 binding protein 1 using the numbering given in entry NP_005648.1 (GeneID 7158).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier folgen Informationen zur Produktreferenz. mehr
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-53BP1"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen