Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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TY-52156
Item number: TGM-T17183-200mg
Description: TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM). Target: LPL Receptor, S1P Receptor. Smiles: CC(C)(C)C(=O)C(\NNc1ccc(Cl)cc1)=N\c1ccc(Cl)cc1
| Application: | S1PR3 antagonist |
| CAS | 934369-14-9 |
| MW: | 364.27 D |
From 33.00€
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Dasatinib
Item number: TGM-T1448-50mg
Description: Dasatinib (BMS-354825) is an orally active, ATP-competitive tyrosine kinase inhibitor that targets Src and Bcr-Abl (Ki=16/30 pM), with antitumor activity, used in the treatment of leukemia and lymphoma. Target: c-Kit, Autophagy, Bcr-Abl, Apoptosis, Src. Smiles:...
| Keywords: | BMS-354825 |
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 302962-49-8 |
| MW: | 488.01 D |
From 36.00€
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Rapamycin
Item number: TGM-T1537-10mg
Description: Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy. Target: Autophagy, Antibiotic, mTOR, Antifungal, Endogenous Metabolite, Others. Smiles:...
| Keywords: | NSC-2260804, AY 22989, Sirolimus |
| Application: | Targets serine/threonine-protein kinase mTOR [EC:2.7.11.1] (MTOR, FRAP, TOR) |
| CAS | 53123-88-9 |
| MW: | 914.17 D |
From 30.00€
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Lumiflavine
Item number: TGM-T20953-10mg
Description: Lumiflavine (Lumilactoflavin) inhibits riboflavin uptake. It is produced by the photolysis of vitamin B2. Target: Others. Smiles: Cc1cc2nc3c(nc(=O)[nH]c3=O)n(C)c2cc1C. References: Ahmad I, Anwar Z, Sheraz MA, Ahmed S, Khattak SU. Stability-indicating spectrofluorimetric method for the assay of...
| Keywords: | Lumilactoflavin, Lumiflavin |
| CAS | 1088-56-8 |
| MW: | 256.26 D |
From 35.00€
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Finerenone
Item number: TGM-T21395-5mg
Description: Finerenone (BAY-948862) is a nonsteroidal antagonist of the mineralocorticoid receptor (MR) (IC50=18 nM) with selective and oral activity. Finerenone is used in the treatment of patients with chronic kidney disease with type 2 diabetes. Target: Glucocorticoid Receptor. Smiles:...
| Keywords: | BAY-948862, BAY948862, BAY94-8862, BAY 94-8862, BAY-94-8862, BAY 948862 |
| CAS | 1050477-31-0 |
| MW: | 378.42 D |
From 30.00€
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RSL3
Item number: TGM-T3646-2mg
Description: RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS. Target: GPX, Glutathione Peroxidase, Ferroptosis. Smiles:...
| Keywords: | 1S,3R-RSL3, RSL3 1S |
| Application: | GPX4 inhibitor |
| CAS | 1219810-16-8 |
| MW: | 440.88 D |
From 32.00€
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CA-074 methyl ester
Item number: TGM-T3420-5mg
Description: CA-074 methyl ester (Cathepsin B Inhibitor IV) is a selective inhibitor of Cathepsin B (IC50=36.3 nM). CA-074 methyl ester has neuroprotective, anti-inflammatory and anti-cancer effects. Target: Cysteine Protease. Smiles: CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N1CCC[C@H]1C(=O)OC
| Keywords: | Cathepsin B Inhibitor IV , CA-074Me |
| Application: | Cell-permeable cathepsin B / L inhibitor |
| CAS | 147859-80-1 |
| MW: | 397.47 D |
From 51.00€
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SP600125
Item number: TGM-T3109-10mg
Description: SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive properties. SP600125 inhibits autophagy and induces apoptosis. Target: Apoptosis, Aurora Kinase, Autophagy, Ferroptosis, JNK, Trk receptor....
| Keywords: | Nsc75890, Pyrazolanthrone, 1PMV, JNK Inhibitor II |
| Application: | Reversible, ATP-competitive JNK1/JNK2/JNK3 inhibitor |
| CAS | 129-56-6 |
| MW: | 220.23 D |
From 39.00€
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Importazole
Item number: TGM-T3445-5mg
Description: Importazole is an inhibitor of the nuclear transport receptor importin-beta. Target: Others, Apoptosis. Smiles: CC(Nc1nc(nc2ccccc12)N1CCCC1)c1ccccc1. References: Soderholm JF, et al. ACS Chem Biol. 2011, 6(7):700-8.
| Application: | Cell-permeable importin-beta inhibitor |
| CAS | 662163-81-7 |
| MW: | 318.42 D |
From 45.00€
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Phosphoramide mustard
Item number: TGM-T38410-1mg
Description: Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage. Target: Drug Metabolite, DNA Alkylation. Smiles: O=P(O)(N)N(CCCl)CCCl. References: Shanthi Ganesan, et al. Phosphoramide mustard exposure induces DNA adduct formation...
| CAS | 10159-53-2 |
| MW: | 221.02 D |
276.00€
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DL-5-Hydroxylysine hydrochloride
Item number: TGM-T4937-25mg
Description: DL-5-Hydroxylysine hydrochloride (5-hydroxylysine hydrochloride) is a racemic mixture of D- and L- enantiomers of 5-hydroxylysine which may be used as potential target markers for radical-induced protein oxidation. Target: Endogenous Metabolite, Others. Smiles: Cl.NCC(O)CC[C@H](N)C(O)=O
| Keywords: | 5-hydroxylysine hydrochloride |
| CAS | 13204-98-3 |
| MW: | 198.65 D |
29.00€
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Z-VAD-FMK
Item number: TGM-T7020-1mg
Description: Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not inhibit UCHL1 activity, even at concentrations up to 440 µM. Target: Caspase, Apoptosis. Smiles:...
| Keywords: | Z-VAD(OH)-FMK , Caspase Inhibitor VI |
| CAS | 161401-82-7 |
| MW: | 453.46 D |
From 113.00€
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