Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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E17241
Item number: TGM-T201355-100mg
Description: E17241 functions as an inducer of ABCA1 gene expression, effectively increasing its expression with an EC50 value of 280 nM. It also acts as an agonist for peroxisome proliferator-activated receptors (PPARs), inducing PPAR-mediated gene expression in HepG2 cells expressing PPARgamma, PPARalpha, or...
| Keywords: | 4-(1,3-Dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide |
| MW: | 318.41 D |
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WYneN
Item number: TGM-T201357-100mg
Description: WYneN is a chemoselective probe designed for the detection of sulfenylated proteins in living cells. In these cells, WYneN binds to sulfenylated proteins and can further interact with azide-containing fluorescent probes for detection purposes. Target: Others. Smiles:...
| Keywords: | Wittig-alkyne N |
| MW: | 438.3 D |
From 1,440.00€
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WYneO
Item number: TGM-T201358-100mg
Description: WyneO serves as a probe for detecting thioacylated proteins. Target: Others. Smiles: [Br-].O=C(OCC#C)C[P+](C=1C=CC=CC1)(C=2C=CC=CC2)C=3C=CC=CC3
| Keywords: | Wittig-alkyne O |
| MW: | 439.28 D |
From 1,440.00€
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8beta,9beta-epoxy Hexahydrocannabinol
Item number: TGM-T201359-100mg
Description: 8beta,9beta-epoxy Hexahydrocannabinol is an active metabolite of Delta8-THC and a phytocannabinoid derivative, known to extend barbiturate-induced sleep duration in mice. Smiles: OC1=C2[C@]3([C@@](C[C@@]4([C@](C)(C3)O4)[H])(C(C)(C)OC2=CC(CCCCC)=C1)[H])[H]
| Keywords: | 8beta,9beta-epoxy HHC , 8beta,9beta-EHHC |
| MW: | 330.46 D |
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Alkyne-tagged Dopamine hydrochloride
Item number: TGM-T201362-100mg
Description: Alkyne-tagged dopamine is an endogenous neurotransmitter dopamine derivative designed for click chemistry, already conjugated with a fluorescent group, and used in research to characterize dopamine dynamics. Target: Others. Smiles: Cl.C#CCNCCC1=CC=C(O)C(O)=C1
| MW: | 227.69 D |
From 1,583.00€
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ART899
Item number: TGM-T201365-100mg
Description: ART899, a derivative of ART558, is a potent and specific conformational inhibitor of DNA polymerase theta (Poltheta). It specifically inhibits the MMEJ activity of Poltheta with an IC50 of 180 nM. Additionally, ART899 selectively enhances the radiosensitivity of tumor cells and possesses a strong...
| MW: | 464.81 D |
From 2,437.00€
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TAC
Item number: TGM-T201368-100mg
Description: TAC (TERT activator compound) is a TERT (telomerase reverse transcriptase) activator that enhances TERT transcriptional activity through the MEK/ERK/AP-1 cascade pathway, promotes telomere synthesis in primary human cells and naturally aged mice, reduces cellular senescence and inflammatory cytokines,...
| Keywords: | TERT activator-1 , TERT activator compound |
| MW: | 331.77 D |
From 30.00€
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NIBR-LTSi
Item number: TGM-T201369-10mg
Description: NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration both in vitro and in vivo, accelerates liver regeneration in a mouse partial hepatectomy model, and is capable of expanding organoids derived from several mouse...
| MW: | 308.38 D |
From 75.00€
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XYL-1
Item number: TGM-T201372-100mg
Description: XYL-1 is a potent PARP7 inhibitor with an IC50 of 0.6 nM. It has the capability to enhance type I interferon signaling in vitro, positioning it as a potential candidate for the development of cancer immunotherapy drugs. Smiles: O=C1NN=CC(NCCCCNC(=O)N2CCN(C3=NC=C(C=N3)C(F)(F)F)CC2)=C1C(F)(F)F
| MW: | 508.42 D |
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AZ 14145845
Item number: TGM-T201375-100mg
Description: AZ 14145845, a potent and highly selective dual Mer/Axl kinase inhibitor (pIC50 = 7 nM and 7.8 nM in pAxl and pMer, respectively), demonstrates significant efficacy in reducing tumor growth in a dose-dependent manner within the Mer and Axl kinase Ba/F3 tumor xenograft model in vivo. When combined with...
| MW: | 561.68 D |
From 1,440.00€
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BAY 593
Item number: TGM-T201377-100mg
Description: BAY 593 functions as an inhibitor of geranylgeranyltransferase-I (GGTase-I), effectively preventing the activation of Rho-GTPases and consequently inactivating YAP1/TAZ signaling pathways. It has been shown to inhibit tumor growth dose-dependently in xenograft mouse models, exhibiting IC50 values of...
| MW: | 512.99 D |
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JQ dS-4
Item number: TGM-T201378-10mg
Description: JQ dS-4 is a degrader of Brahma-related gene 1 (BRG1)/BRM/SMARCA4 (PROTAC(R), DC50 range = 9 - 390 nM in glioma models and cell lines), featuring a BRG1 inhibitor connected through a linker to a cereblon (CRBN) E3 ligase ligand. It effectively degrades BRG1 completely over 48 and 72 hours in...
| MW: | 719.15 D |
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