Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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CDK/HDAC-IN-1
Item number: TGM-T61583-100mg
Description: CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively. Target: Others
| MW: | 378.38 D |
From 1,440.00€
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EGFR/HER2/DHFR-IN-1
Item number: TGM-T61596-100mg
Description: EGFR/HER2/DHFR-IN-1 is a highly selective and potent anticancer compound targeting MCF-7 breast cancer cells, acting as a multi-inhibitor for EGFR/HER2 kinase and DHFR enzymes, with IC50 values of 0.153 µM, 0.108 µM, and 0.291 µM, respectively. It induces cell cycle arrest at the G1/S phase and...
| MW: | 379.23 D |
From 1,440.00€
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TLR7/8 antagonist 2
Item number: TGM-T61601-100mg
Description: TLR7/8 antagonist 2 (Compound 15) is a highly potent and orally active agonist of TLR7/8 with IC50 values of 4.9 nM for TLR7 and 0.6 nM for TLR8, making it a promising candidate for treating and investigating autoimmune diseases like lupus erythematosus, which involves inappropriate activation of TLR7...
| MW: | 379.47 D |
From 1,440.00€
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Anticancer agent 35
Item number: TGM-T61602-100mg
Description: Anticancer agent 35 (compound 10), a sulfonylurea derivative, is a potent anticancer agent that inhibits A549, A431, and PACA2 cell growth with IC50 values of 18.1 µg/mL, 4.0 µg/mL, and 18.9 µg/mL, respectively [1]. Target: Others
| MW: | 379.48 D |
From 1,440.00€
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H3R antagonist 2
Item number: TGM-T61603-100mg
Description: H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor antagonist with inhibitory effects on acetylcholinesterase, butyrylcholinesterase, and human monoamine oxidase B (hMAO B) with IC50 values of 180 nM, 880 nM, and 775 nM, respectively. With a Ki of 170 nM for hH3R, it demonstrates...
| MW: | 379.49 D |
From 1,440.00€
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Hcyb1
Item number: TGM-T61617-100mg
Description: Hcyb1 is a potent and specific inhibitor of phosphodiesterase 2 (PDE2). It exhibits a high degree of selectivity for inhibiting PDE2A with an IC50 value of 0.57 µM. In addition, Hcyb1 displays over 250-fold selectivity against other recombinant members of the PDE family. Moreover, its pharmacological...
| MW: | 380.44 D |
From 867.00€
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XN methyl pyrazole
Item number: TGM-T61619-100mg
Description: XN methyl pyrazole exhibits beneficial effects on diet-induced obesity and enhances energy expenditure in mice fed with a high-fat diet [1]. Target: Others
| MW: | 380.44 D |
From 1,440.00€
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AChE/PDE4-IN-1
Item number: TGM-T61620-100mg
Description: AChE/PDE4-IN-1 (compound 12c) is a highly effective and specific dual inhibitor of PDE4 and AChE, with IC50 values of 0.28 µM for AChE and 1.88 µM for PDE4D. This compound shows notable potential in reducing neuroinflammation associated with Alzheimer's disease research [1]. Target: Others
| MW: | 380.48 D |
From 1,440.00€
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GABAA receptor agonist 2
Item number: TGM-T61625-100mg
Description: GABAA receptor agonist 2 (compound 4c) is a highly potent compound that exhibits anti-depressive properties in classical mouse models of depression, such as the FST and TST. By binding to the GABA binding site on the GABAA receptor, it produces GABAergic effects. Notably, compound 4c holds promise for...
| MW: | 380.52 D |
From 1,440.00€
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iMDK quarterhydrate
Item number: TGM-T61627-100mg
Description: iMDK quarterhydrate, a potent PI3K inhibitor, is effective in inhibiting the growth factor MDK (also known as midkine or MK) while demonstrating suppression of non-small cell lung cancer (NSCLC). In combination with a MEK inhibitor, iMDK quarterhydrate demonstrates cooperative inhibition of NSCLC...
| MW: | 380.91 D |
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hCAIX/XII-IN-5
Item number: TGM-T60602-100mg
Description: hCAIX/XII-IN-5 (Coumarin 9a) is an inhibitor of carbonic anhydrase (CA) with excellent selectivity for hCA IX/XII, displaying Kis of 93.3 nM and 85.7 nM over hCA I and hCA II, respectively. It exhibits anti-proliferative activities in cancer cells, delaying the cell cycle and inducing apoptosis [1]....
| MW: | 291.3 D |
From 1,440.00€
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Antibacterial agent 80
Item number: TGM-T60634-100mg
Description: Antibacterial agent 80 (compound 20) demonstrates antibacterial activity [1]. Target: Others
| MW: | 295.47 D |
From 1,440.00€
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