Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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SBI-581
Item number: TGM-T61663-100mg
Description: SBI-581 is an orally active, potent selective inhibitor of serine-threonine kinase TAO3, with an IC 50 of 42 nM. It effectively promotes the accumulation of TKS5alpha at RAB11-positive vesicles and inhibits the formation of invadopodia. Additionally, SBI-581 exhibits reasonable pharmacokinetics in mice...
| MW: | 383.44 D |
From 1,374.00€
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Antibacterial agent 118
Item number: TGM-T61665-100mg
Description: Antibacterial agent 118 (also known as compound 20) is a potent antimycobacterial compound with activity against various mycobacterial strains, including Mtb H37Ra, M. aurum, M. smegmatis, Mtb H37Rv, and M. avium. The minimum inhibitory concentration (MIC) values for Antibacterial agent 118 against...
| MW: | 383.47 D |
From 1,440.00€
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CHIKV-IN-3
Item number: TGM-T61675-100mg
Description: CHIKV-IN-3 is a potent inhibitor effective against two low-passage CHIKV strains, with EC50 values of 1.55 µM for CHIKV-122508 and 0.14 µM for CHIKV-6708, respectively. It targets host cells to disrupt viral replication while maintaining minimal cytotoxic liability (CC50 > 100 µM). Additionally,...
| MW: | 383.95 D |
From 1,440.00€
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Nrf2 activator-2
Item number: TGM-T61688-100mg
Description: Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 µM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 activator-2 activates the Nrf2 pathway. Furthermore, this compound significantly reduces...
| MW: | 385.25 D |
From 932.00€
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AZD 2066 hydrate
Item number: TGM-T61708-25mg
Description: AZD 2066 hydrate is a selective, orally active, brain-penetrant mGluR5 antagonist with antinociceptive effects [1]. Target: Others
| MW: | 386.33 D |
From 1,364.00€
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AMS-17
Item number: TGM-T61709-100mg
Description: AMS-17 is a potent NLRP3 inhibitor that effectively suppresses microglia activation both in vitro and in vivo. Moreover, AMS-17 exhibits inhibitory effects on various cytokines, such as caspase-1, TNF-alpha, IL-1beta, and inducible nitric oxide synthase (iNOS), in N9 cells, making it a promising tool...
| MW: | 386.35 D |
From 1,440.00€
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Trk-IN-8
Item number: TGM-T61712-100mg
Description: Trk-IN-8, a powerful TRK inhibitor, demonstrates excellent potency against TRKAa, TRKA(G595R), and TRKC(G623R) with IC50 values of 0.42 nM, 0.89 nM, and 1.5 nM, respectively (WO2021115401A1, compound 3) [1]. Target: Others
| MW: | 386.36 D |
From 1,440.00€
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COX-2-IN-13
Item number: TGM-T61714-100mg
Description: COX-2-IN-13 (compound 13e) is a highly potent and selective COX-2 inhibitor with an impressive IC50 value of 0.98 µM. It exhibits strong anti-inflammatory activity and has shown favorable results in in vivo acute toxicity studies [1]. Target: Others
| MW: | 386.42 D |
From 1,440.00€
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Steroid sulfatase/17beta-HSD1-IN-1
Item number: TGM-T61716-100mg
Description: Steroid sulfatase/17beta-HSD1-IN-1 is a highly effective inhibitor of steroid sulfatase and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) activities, with an IC50 value of 28 nM against cellular human steroid sulfatase. This compound holds significant potential for investigating...
| MW: | 386.42 D |
From 1,440.00€
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mPGES-1-IN-1
Item number: TGM-T61718-100mg
Description: MPGES-1, a promising therapeutic target for the next generation of anti-inflammatory drugs in treating inflammatory diseases, possesses an IC50 value of 0.03 µM for mPGES-1-IN-1. Target: Others
| MW: | 386.43 D |
From 1,440.00€
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Pol I-IN-1
Item number: TGM-T61720-100mg
Description: Pol I-IN-1 is a potent inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, with an inhibition concentration (IC50) of 0.21 µM [1]. Target: Others
| MW: | 386.45 D |
From 1,440.00€
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SS-RJW100
Item number: TGM-T61723-100mg
Description: SS-RJW100 is an enantiomer of RJW100, known as a racemic agonist that targets two nuclear receptors: liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). In vitro experiments reveal that SS-RJW100 promotes the recruitment of coregulator protein fragments and enhances the interaction with...
| MW: | 386.57 D |
From 1,440.00€
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